Alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observation

Rogers, Jeremy D.; Stoyneva, Valentina; Turzhitsky, Vladimir; Mutyal, Nikhil N.; Pradhan, Prabhakar; Capoglu, Ilker; Backman, Vadim

doi:10.1364/oe.19.011922

Cited by 8 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The design and theory behind the fiber-optic LEBS probe (assembled by OFS, Avon, CT) have been detailed elsewhere [4] , [19] . Briefly, the LEBS probe consists of a linear array of 4 optical fibers shown in Figure 1c .…”

Section: Methodsmentioning

confidence: 99%

Buccal Spectral Markers for Lung Cancer Risk Stratification

et al. 2014

Self Cite

View full text Add to dashboard Cite

Lung cancer remains the leading cause of cancer deaths in the US with >150,000 deaths per year. In order to more effectively reduce lung cancer mortality, more sophisticated screening paradigms are needed. Previously, our group demonstrated the use of low-coherence enhanced backscattering (LEBS) spectroscopy to detect and quantify the micro/nano-architectural correlates of colorectal and pancreatic field carcinogenesis. In the lung, the buccal (cheek) mucosa has been suggested as an excellent surrogate site in the “field of injury”. We, therefore, wanted to assess whether LEBS could similarly sense the presence of lung. To this end, we applied a fiber-optic LEBS probe to a dataset of 27 smokers without diagnosed lung cancer (controls) and 46 with lung cancer (cases), which was divided into a training and a blinded validation set (32 and 41 subjects, respectively). LEBS readings of the buccal mucosa were taken from the oral cavity applying gentle contact. The diagnostic LEBS marker was notably altered in patients harboring lung cancer compared to smoking controls. The prediction rule developed on training set data provided excellent diagnostics with 94% sensitivity, 80% specificity, and 95% accuracy. Applying the same threshold to the blinded validation set yielded 79% sensitivity and 83% specificity. These results were not confounded by patient demographics or impacted by cancer type or location. Moreover, the prediction rule was robust across all stages of cancer including stage I. We envision the use of LEBS as the first part of a two-step paradigm shift in lung cancer screening in which patients with high LEBS risk markers are funnelled into more invasive screening for confirmation.

show abstract

Section: Methodsmentioning

confidence: 99%

Buccal Spectral Markers for Lung Cancer Risk Stratification

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…1C have previously been described in other publications (30, 31). In short, the LEBS probe (assembled by OFS, Avon, CT; schematic in Fig.…”

Section: Methodsmentioning

confidence: 88%

Rectal Optical Markers for In Vivo Risk Stratification of Premalignant Colorectal Lesions

Radosevich

Mutyal

Eshein

et al. 2015

Clinical Cancer Research

Self Cite

View full text Add to dashboard Cite

Purpose Colorectal cancer remains the second leading cause of cancer deaths in the U.S. despite being eminently preventable by colonoscopy via removal of premalignant adenomas. In order to more effectively reduce colorectal cancer mortality, improved screening paradigms are needed. Our group pioneered the use of low coherence enhanced backscattering (LEBS) spectroscopy to detect the presence of adenomas throughout the colon via optical interrogation of the rectal mucosa. In a previous ex-vivo biopsy study of 219 patients, LEBS demonstrated excellent diagnostic potential with 89.5% accuracy for advanced adenomas. The objective of the current cross-sectional study is to assess the viability of rectal LEBS in-vivo. Experimental Design Measurements from 619 patients were taken using a minimally invasive 3.4 mm diameter LEBS probe introduced into the rectum via anoscope or direct insertion, requiring ~1 minute from probe insertion to withdrawal. The diagnostic LEBS marker was formed as a logistic regression of the optical reduced scattering coefficient μs∗ and mass density distribution factor D. Results The rectal LEBS marker was significantly altered in patients harboring advanced adenomas and multiple non-advanced adenomas throughout the colon. Blinded and cross-validated test performance characteristics showed 88% sensitivity to advanced adenomas, 71% sensitivity to multiple non-advanced adenomas, and 72% specificity in the validation set. Conclusions We demonstrate the viability of in-vivo LEBS measurement of histologically normal rectal mucosa to predict the presence of clinically relevant adenomas throughout the colon. The current work represents the next step in the development of rectal LEBS as a tool for colorectal cancer risk stratification.

show abstract

“…As an attractive alternative, polarized light Monte Carlo simulations give an exact solution to the radiative transfer equation (provided that a sufficient number of rays are traced). Modeling of the EBS peak using Monte Carlo simulations is fairly common and demonstrates an excellent agreement with experiment [12], [22]–[24], [26], [29], [34], [36]. In addition all effects of partial spatial coherence illumination and polarization can be described using this model [16], [25], [26], [30], [34], [36].…”

Section: Introductionmentioning

confidence: 87%

Polarized Enhanced Backscattering Spectroscopy for Characterization of Biological Tissues at Subdiffusion Length Scales

Radosevich

Rogers

Turzhitsky

et al. 2012

IEEE J. Select. Topics Quantum Electron.

Self Cite

View full text Add to dashboard Cite

Since the early 1980’s, the enhanced backscattering (EBS) phenomenon has been well-studied in a large variety of non-biological materials. Yet, until recently the use of conventional EBS for the characterization of biological tissue has been fairly limited. In this work we detail the unique ability of EBS to provide spectroscopic, polarimetric, and depth-resolved characterization of biological tissue using a simple backscattering instrument. We first explain the experimental and numerical procedures used to accurately measure and model the full azimuthal EBS peak shape in biological tissue. Next we explore the peak shape and height dependencies for different polarization channels and spatial coherence of illumination. We then illustrate the extraordinary sensitivity of EBS to the shape of the scattering phase function using suspensions of latex microspheres. Finally, we apply EBS to biological tissue samples in order to measure optical properties and observe the spatial length-scales at which backscattering is altered in early colon carcinogenesis.

show abstract

Alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observation

Cited by 8 publications

References 13 publications

Buccal Spectral Markers for Lung Cancer Risk Stratification

Buccal Spectral Markers for Lung Cancer Risk Stratification

Rectal Optical Markers for In Vivo Risk Stratification of Premalignant Colorectal Lesions

Polarized Enhanced Backscattering Spectroscopy for Characterization of Biological Tissues at Subdiffusion Length Scales

Contact Info

Product

Resources

About