Alternate circulation and genetic variation of human respiratory syncytial virus genotypes in Chengdu, West China, 2009‐2014

Abstract

Human respiratory syncytial virus (HRSV) is a major pathogen that causes worldwide seasonal epidemic disease in infants due to its genetic variations. However, published information on the molecular epidemiology of HRSV was never reported particularly in Chengdu of West China. During five consecutive seasons (from 2009 to 2014), 433 (23.7%) of 1827 samples from hospitalized patients were identified as HRSV positive. Epidemiological characteristics of HRSV revealed that subtype A viruses (62.7%) prevailed in the first three epidemic seasons and faded in the next two seasons, while subtype B viruses (37.3%) kept circulating in five epidemic periods. According to the phylogenetic analysis of glycoprotein (G) gene, five HRSV genotypes NA1, ON1, BA9, BA-C, and CB1 were found in Chengdu. The predominant circulating genotype changed from NA1 in the period of 2010-2012 to BA9 of 2013-2014. The newly emerging ON1 was first reported in West China in October 2013. The early genotypes BA-C and CB1 were replaced by the prevailing BA9 after the third epidemic peak. Genetic mutations in glycosylation sites of G protein were found in HRSV variants, suggesting the virus is able to escape the immune recognition and attack. This study elucidated the local HRSV epidemic was associated with the alternate circulation of multiple genotypes and with the change of glycosylation sites of G protein. J. Med. Virol. 89:32-40, 2017. © 2016 Wiley Periodicals, Inc.

Epidemiological characteristics and phylogenic analysis of human respiratory syncytial virus in patients with respiratory infections during 2011–2016 in southern China

“…To better understand the epidemiological characteristics of RSV subtypes, RSV-A and RSV-B subtypes were determined based on 623 RSV-positive samples from 13 hospitals. The results showed that RSV-A was the dominant subtype circulating in Guangzhou during 2011-2016, consistent with reports from other regions (Hu et al, 2017;Slovic et al, 2016). The three patients with co-detection were all infants and toddlers and inpatients with ALRI, and none of them died.…”

Human cytomegalovirus prevalence and distribution of glycoprotein B, O genotypes among hospitalized children with respiratory infections in West China, 2009–2014

“…Considering HCMV reactivation/reinfection, seasonality has rarely been discussed . Due to weather conditions from winter to spring and prevalent features of certain viruses , the proportion of detected HCMV infections may rise with the growth of the incidence of RI, regardless of primary or secondary infections.…”

Infections Caused by HRSV A ON1 Are Predominant among Hospitalized Infants with Bronchiolitis in São Paulo City

“…Several genotypes have been described in subgroups A (GA1 to GA7, SAA1 and NA1, NA2) and B (URU1, URU2, and GB1 to GB4, SAB1 to SAB3, and BA1 to BA13). The recently described genotype HRSV A ON1 is characterized by the duplication of 72 nucleotides in gene G. After being reported in Canada, HRSVA ON1 has also been identified in Europe, India, Africa, South America, and Asia [6][7][8][9][10][11].…”