Alternariol derivatives from Alternaria alternata, an endophytic fungus residing in red sea soft coral, inhibit HCV NS3/4A protease

Hawas, Usama W.; El‐Desouky, Samy K.; El-Kassem, Lamia T. Abou; Elkhateeb, Waill A

doi:10.1134/s0003683815050099

Cited by 23 publications

(18 citation statements)

References 14 publications

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“…324 Alternariol-9-methyl ether 3-O-sulfate 545, previously obtained from Alternaria sp., an endophyte of the Egyptian medicinal plant Polygonum senegalense, 325 was obtained for the rst time from the marine environment from endophytic Alternaria alternata. 326 The norditerpenes aspewentin A-C (Aspergillus wentii 327 ) have been synthesised 328 as have the prenylated indole alkaloids, (+)-notoamide I (Aspergillus sp.) 329 and (À)-17hydroxy-citrinalin B (Penicillium citrinum) 330 via a unied strategy.…”

Section: Marine-sourced Fungi (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2017

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Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Marine-sourced Fungi (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2017

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“…An aqueous extract with a low molecular weight (< 3 kDa) fraction of the white button mushroom (Agaricus bisporus) has displayed a responsible activity to the indictors of HCV replication [88]. Alternaroil and alternariol derivatives (alternariol-9-methyl ether-3-O-sulphate and alternariol-9-methyl ether) of an endophytic fungus, Alternaria alternate, and their metabolites were explored for the inhibition of HCV NS3-NS4A protease [89][90][91][92]. Hawas et al [93] found that the most potent HCV NS3/4A protease isolated compound that was obtained from Fusarium equiseti were ω-hydroxyemodin and Griseoxanthone C. Furthermore, mellein, patulin, and H1-A were isolated from Aspergillus ochraceus, Penicillium griseofulvum, and Fusarium oxysporum, respectively.…”

Section: Hcv Ns3/4a Protease Inhibitors Isolated From Fungimentioning

confidence: 99%

Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

et al. 2020

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The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effects and they can become ineffective due to eventual drug resistance. Thus, the search for natural bioactive compounds that were obtained from bio-resources that exert inhibitory capabilities against HIV-1 protease activity is of great interest. Fungi are a source of natural bioactive compounds that offer therapeutic potential in the prevention of viral diseases and for the improvement of human immunomodulation. Here, we made a brief review of the current findings on fungi as producers of protease inhibitors and studies on the relevant candidate fungal bioactive compounds that can offer immunomodulatory activities as potential therapeutic agents of coronaviruses in the future.

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“…Various compounds have recently been extracted from microorganisms that were isolated from octocorals. For example, several phenyl ethers, anthraquinones and alkaloids with anti-fouling properties [ 220 ], and merosesquitepenoids, macrolides and alternariol derivatives with antibacterial [ 221 , 222 ] and potentially antiviral activities [ 222 ], were derived from symbiotic fungi associated with soft corals. Various bacteria belonging to the Firmicutes, Actinobacteria, and Gammaproteobacteria isolated from tropical and temperate octocorals have also been shown to possess potent antibacterial and antifungal activities [ 223 – 225 ]; however, only the antimicrobial cyclic tetrapeptide Cereustatin A and two esters of p -hydroxybenzoic acid have so far been extracted and characterized [ 226 ].…”

Section: Microbiome Regulationmentioning

confidence: 99%

Host-microbe interactions in octocoral holobionts - recent advances and perspectives

2018

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Octocorals are one of the most ubiquitous benthic organisms in marine ecosystems from the shallow tropics to the Antarctic deep sea, providing habitat for numerous organisms as well as ecosystem services for humans. In contrast to the holobionts of reef-building scleractinian corals, the holobionts of octocorals have received relatively little attention, despite the devastating effects of disease outbreaks on many populations. Recent advances have shown that octocorals possess remarkably stable bacterial communities on geographical and temporal scales as well as under environmental stress. This may be the result of their high capacity to regulate their microbiome through the production of antimicrobial and quorum-sensing interfering compounds. Despite decades of research relating to octocoral-microbe interactions, a synthesis of this expanding field has not been conducted to date. We therefore provide an urgently needed review on our current knowledge about octocoral holobionts. Specifically, we briefly introduce the ecological role of octocorals and the concept of holobiont before providing detailed overviews of (I) the symbiosis between octocorals and the algal symbiont Symbiodinium; (II) the main fungal, viral, and bacterial taxa associated with octocorals; (III) the dominance of the microbial assemblages by a few microbial species, the stability of these associations, and their evolutionary history with the host organism; (IV) octocoral diseases; (V) how octocorals use their immune system to fight pathogens; (VI) microbiome regulation by the octocoral and its associated microbes; and (VII) the discovery of natural products with microbiome regulatory activities. Finally, we present our perspectives on how the field of octocoral research should move forward, and the recognition that these organisms may be suitable model organisms to study coral-microbe symbioses.

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Alternariol derivatives from Alternaria alternata, an endophytic fungus residing in red sea soft coral, inhibit HCV NS3/4A protease

Cited by 23 publications

References 14 publications

Marine natural products

Marine natural products

Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

Host-microbe interactions in octocoral holobionts - recent advances and perspectives

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