Abstract:The multifunctionality of galectins helps regulate a broad range of fundamental cellular processes via cis‐binding and trans‐bridging activities and has gained widespread attention with respect to the importance of the natural specificity/selectivity of this lectin family to its glycoconjugate receptors. Combining galectin (Gal)‐1, −3, −4, and −9 variant test panels, achieved via rational protein engineering, and a synthetic α‐dystroglycan (DG) O‐Mannosylated core M1 glycopeptide library, a detailed comparativ… Show more
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