Altering the Crosslinking Density of Polyacrylamide Hydrogels to Increase Swelling Capacity and Promote Calcium Hydroxide Growth in Cement Voids

Davis, Cole R.; Bose, Baishakhi; Alcaraz, Alejandro M.; Martínez, Carlos; Erk, Kendra A.

doi:10.1007/978-3-030-33342-3_3

Cited by 8 publications

(7 citation statements)

References 7 publications

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Section: Resultsmentioning

confidence: 99%

“…This may be attributable to a slight swelling of the silkMA hydrogel over a 28-day period, which may be limited in pMHMGCL:PCL-silkMA scaffolds due to the presence of covalent bonds between hydrogel with the fibers. 73,74 Furthermore, the tests showed that after 28 days an approximately 3-fold difference in compression modulus value was observed between samples with and without covalent interactions at the interface between the materials. Moreover, as shown in Figure S8, a significant increase in compression modulus is observed in the pMHMGCL-silkMA samples with eqACPCs compared to the cell-free controls, which is in contrast to the samples without the interface interactions (pHMGCL-silkMA) where no significant difference in compression modulus is observed for samples with and without embedded cells.…”

Section: Biological Compatibility and Functionality Of Polymer Blendsmentioning

confidence: 99%

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Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructs

Viola,

Ainsworth,

Mihajlovic

et al. 2024

Biomacromolecules

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Hydrogels are ideal materials to encapsulate cells, making them suitable for applications in tissue engineering and regenerative medicine. However, they generally do not possess adequate mechanical strength to functionally replace human tissues, and therefore they often need to be combined with reinforcing structures. While the interaction at the interface between the hydrogel and reinforcing structure is imperative for mechanical function and subsequent biological performance, this interaction is often overlooked. Melt electrowriting enables the production of reinforcing microscale fibers that can be effectively integrated with hydrogels. Yet, studies on the interaction between these micrometer scale fibers and hydrogels are limited. Here, we explored the influence of covalent interfacial interactions between reinforcing structures and silk fibroin methacryloyl hydrogels (silkMA) on the mechanical properties of the construct and cartilage-specific matrix production in vitro. For this, melt electrowritten fibers of a thermoplastic polymer blend (poly(hydroxymethylglycolide-co-ε-caprolactone):poly(ε-caprolactone) (pHMGCL:PCL)) were compared to those of the respective methacrylated polymer blend pMHMGCL:PCL as reinforcing structures. Photopolymerization of the methacrylate groups, present in both silkMA and pMHMGCL, was used to generate hybrid materials. Covalent bonding between the pMHMGCL:PCL blend and silkMA hydrogels resulted in an elastic response to the application of torque. In addition, an improved resistance was observed to compression (∼3-fold) and traction (∼40−55%) by the scaffolds with covalent links at the interface compared to those without these interactions. Biologically, both types of scaffolds (pHMGCL:PCL and pMHMGCL:PCL) showed similar levels of viability and metabolic activity, also compared to frequently used PCL. Moreover, articular cartilage progenitor cells embedded within the reinforced silkMA hydrogel were able to form a cartilage-like matrix after 28 days of in vitro culture. This study shows that hybrid cartilage constructs can be engineered with tunable mechanical properties by grafting silkMA hydrogels covalently to pMHMGCL:PCL blend microfibers at the interface.

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Section: Resultsmentioning

confidence: 99%

Section: Biological Compatibility and Functionality Of Polymer Blendsmentioning

confidence: 99%

Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructs

Viola,

Ainsworth,

Mihajlovic

et al. 2024

Biomacromolecules

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“…First, shear forces encountered during mixing will likely change the size distribution of SAP particles [87] as well as their sorption kinetics which are dependent on particle size and surface area [9,86]. Secondly, geometric confinement due to the presence of solids may interfere with the volumetric expansion of the hydrogel particles [93,[104][105][106][107].…”

Section: Sorption Kinetics and Physico-chemical Mechanisms Of Superab...mentioning

confidence: 99%

“…Additionally, in real cementitious mixtures, the physical confinement imposed by the surrounding cement grains and aggregate solids may limit the free volumetric swelling of a SAP, especially for SAP particles with relatively low bulk modulus values such as compositions with a low covalent crosslink density [93,104,114]. Farzanian et al have experimentally demonstrated that enhancing mechanical pressure from zero (free swelling) to 3.4 kPa and hence, volumetric confinement, of a collective of SAP particles exposed to distilled water reduces its volumetric equilibrium swelling extent from 275 to only ten [105].…”

Section: Sorption Kinetics and Physico-chemical Mechanisms Of Superab...mentioning

confidence: 99%

Recent progress in superabsorbent polymers for concrete

Schröfl

Erk

Siriwatwechakul

et al. 2022

Cement and Concrete Research

108

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“…Because the interface between cement paste and aggregate is rich in CH, the crystal surface becomes a weak link. MK can quickly absorb part of CH to produce a secondary hydration reaction and promote the formation of AFt and CSH − gel, thus improving the orientation of CH in the interface area and reducing the content. − This is conducive to the improvement of not only the mechanical properties of concrete but also durability. Therefore, many researchers have made effort to reveal the basic reaction between MK and cement hydration products.…”

Section: Introductionmentioning

confidence: 99%

Molecular Insight into the Pozzolanic Reaction of Metakaolin and Calcium Hydroxide

et al. 2023

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The reaction mechanism of the pozzolanic reaction of metakaolin (MK) from the atomic point of view has not yet been explored. To explain the process and mechanism of the pozzolanic reaction from the atomic point of view, molecular insight into the pozzolanic reaction of MK and calcium hydroxide (CH) was analyzed through the reaction molecular dynamics (MD) simulation. The results show that the pozzolanic reaction of MK and CH can be essentially regarded as the CH decomposition and penetration into MK. Also, the structure evolution after the pozzolanic reaction shows that the water molecules cannot penetrate the MK structure till the participation of Ca2+ and OH– ions of CH. The Ca2+ and OH– ions have strong interaction with MK and drill into the MK structure, followed by the destruction of a part of the MK structure and water penetration. The final structure of CH removed by MK can be regarded as the precursor of the CASH gel structure.

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Altering the Crosslinking Density of Polyacrylamide Hydrogels to Increase Swelling Capacity and Promote Calcium Hydroxide Growth in Cement Voids

Cited by 8 publications

References 7 publications

Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructs

Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructs

Recent progress in superabsorbent polymers for concrete

Molecular Insight into the Pozzolanic Reaction of Metakaolin and Calcium Hydroxide

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