Altering stimulus timing via fast rhythmic sensory stimulation induces STDP-like recall performance in human episodic memory

Wang, Danying; Shapiro, Kimron L.; Hanslmayr, Simon

doi:10.1101/2022.11.02.514843

Cited by 3 publications

(8 citation statements)

References 63 publications

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“…Finally, subthreshold synaptic inputs are a key substrate for synaptic plasticity. Indeed, two separate studies in mice and humans have recently suggested that 40 Hz stimulation can enhance synaptic plasticity [64,69].…”

Section: The Brain-wide Neuronal Response To Gamma Stimulationmentioning

confidence: 99%

Audiovisual gamma stimulation for the treatment of neurodegeneration

Blanco‐Duque,

Chan,

Kahn

et al. 2023

J Intern Med

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Alzheimer's disease (AD) is the most common type of neurodegenerative disease and a health challenge with major social and economic consequences. In this review, we discuss the therapeutic potential of gamma stimulation in treating AD and delve into the possible mechanisms responsible for its positive effects. Recent studies reveal that it is feasible and safe to induce 40 Hz brain activity in AD patients through a range of 40 Hz multisensory and noninvasive electrical or magnetic stimulation methods. Although research into the clinical potential of these interventions is still in its nascent stages, these studies suggest that 40 Hz stimulation can yield beneficial effects on brain function, disease pathology, and cognitive function in individuals with AD. Specifically, we discuss studies involving 40 Hz light, auditory, and vibrotactile stimulation, as well as noninvasive techniques such as transcranial alternating current stimulation and transcranial magnetic stimulation. The precise mechanisms underpinning the beneficial effects of gamma stimulation in AD are not yet fully elucidated, but preclinical studies have provided relevant insights. We discuss preclinical evidence related to both neuronal and nonneuronal mechanisms that may be involved, touching upon the relevance of interneurons, neuropeptides, and specific synaptic mechanisms in translating gamma stimulation into widespread neuronal activity within the brain. We also explore the roles of microglia, astrocytes, and the vasculature in mediating the beneficial effects of gamma stimulation on brain function. Lastly, we examine upcoming clinical trials and contemplate the potential future applications of gamma stimulation in the management of neurodegenerative disorders.

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Section: The Brain-wide Neuronal Response To Gamma Stimulationmentioning

confidence: 99%

Audiovisual gamma stimulation for the treatment of neurodegeneration

Blanco‐Duque,

Chan,

Kahn

et al. 2023

J Intern Med

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show abstract

“…Later, 24 participants were cued with one of the sounds and recalled the paired video. The other 24 participants were cued with a video and asked to recall the paired sound 22 .…”

Section: Humans Show Neural Response To Gamma Sensory Stimulationmentioning

confidence: 99%

“…Later, 24 participants were cued with one of the sounds and recalled the paired video. The other 24 participants were cued with a video and asked to recall the paired sound 22 . The results ( Figure 1C-E ) not only show phase-locked responses in the hippocampus and prefrontal cortex (PFC) to the stimulation, but they also show that this response is modulated by memory success (i.e., stronger responses to remembered vs. forgotten trials) 22 .…”

Section: Hz Electrophysiological Response Throughout the Brainmentioning

confidence: 99%

“…The other 24 participants were cued with a video and asked to recall the paired sound 22 . The results ( Figure 1C-E ) not only show phase-locked responses in the hippocampus and prefrontal cortex (PFC) to the stimulation, but they also show that this response is modulated by memory success (i.e., stronger responses to remembered vs. forgotten trials) 22 . This suggests the responsiveness of higher-order downstream regions to sensory rhythmic stimulation is modulated by the cognitive state of the brain (e.g.…”

Section: Hz Electrophysiological Response Throughout the Brainmentioning

confidence: 99%

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Gamma sensory stimulation and effects on the brain

Kahn,

Chan,

Wang

et al. 2023

Preprint

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Findings by the Tsai lab and others1–8demonstrate that 40 Hz frequency sensory stimulation induces electrophysiological responses and attenuates pathology in mouse models of Alzheimer’s disease (AD). A recent study inNature Neurosciene9concluded that the stimulation does not affect endogenous gamma oscillations or amyloid burden. We welcome research investigating 40 Hz sensory stimulation, and the article by Soula et al enhances our understanding of the brain’s electrophysiological response to 40Hz. However, we respectfully suggest that the data in Soula et al are consistent with a neuronal response to 40 Hz, which we further support with new data in humans. Moreover we contend the non-significant effects on amyloid are due to technical limitations of the study.

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“…Visual sensory stimulation is a technique in which a stimulus's luminance oscillates over time and aims to modulate ongoing neural activity. While low-frequency sensory stimulation can modulate endogenous low-frequency oscillations 49 and enhance episodic memory formation 50 , and gamma-band sensory stimulation can induce gamma-band activity in the thalamus, visual cortex and hippocampus [51][52][53][54][55] , it remains unclear whether gamma-band sensory stimulation can enhance recall performance above and beyond what is observed when stimulation is not applied. Importantly, as sensory stimulation using fast gamma rhythms (>60Hz) involves flickering the stimuli at rates above the flicker fusion threshold, the flickers are imperceptible to the naked eye and, therefore, may provide an imperceptible intervention to enhance episodic memory.…”

Section: Introductionmentioning

confidence: 99%

Imperceptible gamma-band sensory stimulation enhances episodic memory retrieval

Griffiths

Weinert

Jensen

et al. 2023

Preprint

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Enhanced gamma activity (30-100Hz) coincides with the successful recall of episodic memories, but it remains unknown whether this oscillatory activity is a cause or a consequence of the retrieval process. To address this question, we asked human participants to complete a paired associates memory task while undergoing sensory stimulation (at 65Hz, 43.3Hz and 32.5Hz). We observed that 65Hz and 32.5Hz sensory stimulation enhances recall compared to a baseline condition without stimulation. No similar effect was observed following 43.3Hz stimulation. Notably, while almost all participants could perceive 32.5Hz and 43.3Hz sensory stimulation, only a small proportion of participants (~10%) could perceive the 65Hz visual flicker, suggesting 65Hz sensory stimulation acts as an imperceptible intervention to enhance recall. To understand the dual action of 65Hz and 32.5Hz sensory stimulation on recall, we built three pyramidal-interneuronal network gamma (PING) models and drove them using the same stimulation protocols as in the behavioural task. The behavioural results could be reproduced by stimulating an endogenous ~32Hz oscillation, but not by stimulating an endogenous ~65Hz oscillation nor by stimulating a network without an endogenous oscillation. These results suggest that imperceptible 65Hz sensory stimulation enhances recall by harmonically entraining an endogenous ~32.5Hz oscillation. Based on these findings, we propose that 'slow' gamma oscillations play a causal role in episodic memory retrieval.

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Altering stimulus timing via fast rhythmic sensory stimulation induces STDP-like recall performance in human episodic memory

Cited by 3 publications

References 63 publications

Audiovisual gamma stimulation for the treatment of neurodegeneration

Audiovisual gamma stimulation for the treatment of neurodegeneration

Gamma sensory stimulation and effects on the brain

Imperceptible gamma-band sensory stimulation enhances episodic memory retrieval

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