Altered zinc metabolism in mood disorder patients

Little, Karley Y.; Castellanos, Xavier; Humphries, Laune L.; Austin, J.

doi:10.1016/0006-3223(89)90093-0

Cited by 28 publications

(16 citation statements)

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“…Our findings are in a good agreement with most reports, which demonstrated reduced zinc concentration in the blood (serum, plasma) of depressed patients (Maes et al 1994, 1997, 1999; Russo 2011; McLoughlin and Hodge 1990; Siwek et al 2010; Schlegel-Zawadzka et al 2000; Siwek et al 2013; Roozbeh et al 2011; Irmisch et al 2010; Amani et al 2010; Salimi et al 2008; Wójcik et al 2006; Little et al 1989). However, in some studies blood zinc concentrations did not differ between depressed patients and control healthy volunteers group (Ranjbar et al 2013; Narang et al 1991; Gronli et al 2013; Nguyen et al 2009; Manser et al 1989; Salustri et al 2010).…”

Section: Discussionsupporting

confidence: 91%

The serum zinc concentration as a potential biological marker in patients with major depressive disorder

Styczeń

Sowa-Kućma²,

Siwek

et al. 2016

Metab Brain Dis

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Despite many clinical trials assessing the role of zinc in major depressive disorder (MDD), the conclusions still remain ambiguous. The aim of the present clinical study was to determine and comparison the zinc concentration in the blood of MDD patients (active stage or remission) and healthy volunteers (controls), as well as to discuss its potential clinical usefulness as a biomarker of the disease. In this study 69 patients with current depressive episode, 45 patients in remission and 50 controls were enrolled. The zinc concentration was measured by electrothermal atomic absorption spectrometry (ET AAS). The obtained results revealed, that the zinc concentration in depressed phase were statistically lower than in the healthy volunteers [0.89 vs. 1.06 mg/L, respectively], while the zinc level in patients achieve remission was not significantly different from the controls [1.07 vs. 1.06 mg/L, respectively]. Additionally, among the patients achieve remission a significant differences in zinc concentration between group with and without presence of drug-resistance in the previous episode of depression were observed. Also, patients in remission demonstrated correlation between zinc level and the average number of depressive episodes in the last year. Serum zinc concentration was not dependent on atypical features of depression, presence of psychotic symptoms or melancholic syndrome, age, age of onset or duration of disease, number of episodes in the life time, duration of the episode/remission and severity of depression measured by the Hamilton Rating Scale for Depression (HDRS), and the Montgomery-Asberg Depression Rating Scale (MADRS). Concluding, our findings confirm the correlation between zinc deficit present in the depressive episode, and are consistent with the majority of previous studies. These results may also indicate that serum zinc concentration might be considered as a potential biological marker of MDD.

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Section: Discussionsupporting

confidence: 91%

The serum zinc concentration as a potential biological marker in patients with major depressive disorder

Styczeń

Sowa-Kućma²,

Siwek

et al. 2016

Metab Brain Dis

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“…Hambidge (2000) Pneumonia Kury et al (2002) Acrodermatitis enteropathica García et al (2009) Obesity especially in children Gibson et al (2002) Lack of sexual development in females Leek et al (1988) Delayed skeletal maturation and defective mineralisation of bone (monkeys) Little et al (1989) Possible contributor to loss of appetite Evans (1986) hair loss, impotence, skin lesions, weight loss and delayed wound healing Lyon et al (2003) and Giacconi et al (2004) Hypertension and increased risk factor for atherosclerosis and cardiovascular diseases Mackenzie et al (2007) Altered neonatal and infant behaviour and cognitive and motor performance Fraker (2005) Decreased cell proliferation and increased cell death (apoptosis) Markovits et al (1990) Decreased taste acuity Cousins (1985) and Mocchegiani et al (2008b) Reduced concentration of blood metal transport proteins (ceruloplasmin, albumin and α2-macroglubulin) Meunier et al (2005) High susceptibility to oxidative damage of membrane fractions Marcellini et al (2006) Negative consequences on human behaviour Meunier et al (2005) Decreased absorption of dietary folate Malavolta et al (2010) and Mocchegiani et al 2011) Increased Cu/Zn ratio as predictor of frailty and mortality in old age Mocchegiani et al (2006) Increased inflammation and limited zinc release by Metallothioneins Taysi et al (2008) Decreased erythrocyte and cardiac antioxidant capacity Marcellini et al (2006) Mood disorders Tinker and Rucker (1985) Defective connective tissue Prasad (1985) Weight loss Prasad (1985) Hypogonadism in males Prasad (1985) Growth retardation Prasad (1985) Delayed puberty in adolescents Prasad (1985) Mental lethargy Prasad (1985), Dardenne (2002), and Mocchegiani et al (2007) Altered hormone productions (insulin, glucocorticoids, thyroid hormones, IGF-1, growth hormone, melatonin,...…”

Section: Gur Et Al (2002) Osteoporosismentioning

confidence: 99%

Zinc: dietary intake and impact of supplementation on immune function in elderly

Mocchegiani

Romeo

Malavolta

et al. 2012

AGE

153

119

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The diet in the elderly does not provide a sufficient level of nutrients needed to maintain an adequate healthy status leading to micronutrient deficiencies and impaired immune response with subsequent development of degenerative diseases. Nutrient "zinc" is a relevant micronutrient involved in maintaining a good integrity of many body homeostatic mechanisms, including immune efficiency, owing to its requirement for the biological activity of many enzymes, proteins and for cellular proliferation and genomic stability. Old people aged 60-65 years and older have zinc intakes below 50% of the recommended daily allowance on a given day. Many causes can be involved: among them, altered intestinal absorption, inadequate mastication, psychosocial factors, drugs interactions, altered subcellular processes (zinc transporters (Zip and ZnT family), metallothioneins, divalent metal transporter-1). Zinc supplementation may remodel the immune alterations in elderly leading to healthy ageing. Several zinc trials have been carried out with contradictory data, perhaps due to incorrect choice of an effective zinc supplementation in old subjects showing subsequent zinc toxic effects on immunity. Old subjects with specific IL-6 polymorphism (GG allele carriers; named C−) are more prone for zinc supplementation than the entire old population, in whom correct dietary habits with foods containing zinc (Mediterranean diet) may be sufficient in restoring zinc deficiency and impaired immune response. We summarise the main causes of low zinc dietary intake in elderly reporting an update on the impact of zinc supplementation upon the immune response also on the basis of individual IL-6 polymorphism.

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“…Furthermore, older studies of human subjects reported that Zn deficient individuals have declined taste acuity which can be restored by Zn supplementation (Markovits et al, 1990); however, the literature on this topic appears contradictory (Fairweather-Tait, 1988). Zn deficiency has also been identified as a possible contributor to loss of appetite (Little et al, 1989) and anorexia (Su & Birmingham, 2002), by inhibiting the release of neuropeptide Y (NPY), which is required for receptor activation (Lewenson, 2003). Indeed, NPY regulates a wide variety of physiologic functions (Thorsell & Heilig, 2002) and it is also known to act as an orexigen (a stimulator of food intake).…”

Section: Zinc and Psychological Functionsmentioning

confidence: 99%

Importance of zinc in the elderly: the ZENITH study

Meunier

O’Connor

Maiani³

et al. 2005

Eur J Clin Nutr

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The elderly are at nutritional risk as a result of multiple physiological, social, psychological, and economic factors. Physiological functions naturally decline with age, which may influence absorption and metabolism. Social and economic conditions can adversely affect dietary choices and eating patterns. However, at the same time, the nutrient needs of the elderly for certain nutrient (such as vitamins, minerals, proteins) is higher than for younger adults. This article reviews the importance of zinc (Zn) in elderly people, particularly for behavioural and mental function, micronutrient status, immune and antioxidant system, and bone metabolism.

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Altered zinc metabolism in mood disorder patients

Cited by 28 publications

References 1 publication

The serum zinc concentration as a potential biological marker in patients with major depressive disorder

The serum zinc concentration as a potential biological marker in patients with major depressive disorder

Zinc: dietary intake and impact of supplementation on immune function in elderly

Importance of zinc in the elderly: the ZENITH study

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