Altered white matter integrity of forebrain in treatment-resistant depression: A diffusion tensor imaging study with tract-based spatial statistics

Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum

“…Suppressive ART may therefore be contributing to both depressive symptoms and to alterations in the CC. Incidentally, it may be relevant that measurable MTR and DTI changes in the CC have been reported in association with depression (Gunning-Dixon et al 2008; Benedetti et al 2011; Cole et al 2012; Guo et al 2012; Seok et al 2013; Xu et al 2013). Therapeutic ART could directly or indirectly result in CC changes, which in turn may manifest clinically as depression and functional difficulties.…”

Electroconvulsive therapy mediates neuroplasticity of white matter microstructure in major depression

“…14 A more recent meta-analysis including 11 DTI studies (four overlapping with the prior meta-analysis) pointed to smaller FA in frontal lobe WM, as well as in right fusiform and occipital lobe WM in MDD. 9 Altered FA in the sagittal striatum, 15 which includes intersecting fibers from the SLF, and the inferior longitudinal (ILF) and fronto-occipital fasciculi (IFO), 16, 17, 18, 19, 20 the internal and external capsule, 16,19,21,22 cingulate/cingulum 15,21,23, 24, 25 and other frontal association pathways 18,24, 25, 26 are further reported in independent studies of MDD. Thus, though frontal, limbic and striatal connections are implicated, the regional pattern of altered WM structural connectivity in MDD requires clarification.…”

Microstructural brain abnormalities in medication-free patients with major depressive disorder: a systematic review and meta-analysis of diffusion tensor imaging

“…83 A recent DTI study investigating the association between catechol-O-methyltransferase gene polymorphisms and white matter tract integrity in patients with MDD has found that MDD may be associated with the dysfunctional white matter changes in the CC, and the valine homozygote of catechol-O-methyltransferase gene may enhance these pathological changes. 85 Furthermore, studies by Guo and colleagues 66,86 have demonstrated that abnormalities of white matter tracts, mainly in the projection fibres and CC, may contribute to the pathogenesis of treatment-responsive MDD, 66 and that abnormalities of white matter integrity of neuronal tracts connecting 2 brain hemispheres may play a key role in the pathogenesis of TRD. 86 Therefore, decreased FA in the CC observed in our meta-analysis may be diseaserelated and underlie the deficits in emotional modulation and cognitive processing in patients with MDD.…”

“…85 Furthermore, studies by Guo and colleagues 66,86 have demonstrated that abnormalities of white matter tracts, mainly in the projection fibres and CC, may contribute to the pathogenesis of treatment-responsive MDD, 66 and that abnormalities of white matter integrity of neuronal tracts connecting 2 brain hemispheres may play a key role in the pathogenesis of TRD. 86 Therefore, decreased FA in the CC observed in our meta-analysis may be diseaserelated and underlie the deficits in emotional modulation and cognitive processing in patients with MDD.…”