Altered White Matter Integrity in Adolescents with Prelingual Deafness: A High-Resolution Tract-Based Spatial Statistics Imaging Study

Wen, Ming‐Shien; Li, J.; Tang, Mingliang; Xian, Junfang; Li, W.; Liu, Z.; Liu, S.; Sabel, Bernhard A.; Wang, Z.; He, Hong

doi:10.3174/ajnr.a3370

Cited by 50 publications

(51 citation statements)

References 37 publications

(43 reference statements)

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“…Structurally, auditory cortex in the deaf exhibits significantly less white matter, larger gray matter-white matter ratios, and a steeper increase in the ascending ramus of the left posterior sylvian fissure compared to hearing participants (Emmorey et al, 2003; Meyer et al, 2007; Shibata, 2007) as well as microstructural differences in fractional anisotropy, radial diffusivity, and axial diffusivity (Kim et al, 2009; Li et al, 2011; Miao et al, 2013). These findings alone might imply that Heschl's gyrus would be less-responsive to stimulation in general due to atrophy and functional analyses such as those in the present study are critical to determine the extent to which these regions demonstrate cross-modal neuroplasticity.…”

Section: Discussionmentioning

confidence: 99%

Enhanced peripheral visual processing in congenitally deaf humans is supported by multiple brain regions, including primary auditory cortex

Scott

Karns

Dow

et al. 2014

Front. Hum. Neurosci.

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Brain reorganization associated with altered sensory experience clarifies the critical role of neuroplasticity in development. An example is enhanced peripheral visual processing associated with congenital deafness, but the neural systems supporting this have not been fully characterized. A gap in our understanding of deafness-enhanced peripheral vision is the contribution of primary auditory cortex. Previous studies of auditory cortex that use anatomical normalization across participants were limited by inter-subject variability of Heschl's gyrus. In addition to reorganized auditory cortex (cross-modal plasticity), a second gap in our understanding is the contribution of altered modality-specific cortices (visual intramodal plasticity in this case), as well as supramodal and multisensory cortices, especially when target detection is required across contrasts. Here we address these gaps by comparing fMRI signal change for peripheral vs. perifoveal visual stimulation (11–15° vs. 2–7°) in congenitally deaf and hearing participants in a blocked experimental design with two analytical approaches: a Heschl's gyrus region of interest analysis and a whole brain analysis. Our results using individually-defined primary auditory cortex (Heschl's gyrus) indicate that fMRI signal change for more peripheral stimuli was greater than perifoveal in deaf but not in hearing participants. Whole-brain analyses revealed differences between deaf and hearing participants for peripheral vs. perifoveal visual processing in extrastriate visual cortex including primary auditory cortex, MT+/V5, superior-temporal auditory, and multisensory and/or supramodal regions, such as posterior parietal cortex (PPC), frontal eye fields, anterior cingulate, and supplementary eye fields. Overall, these data demonstrate the contribution of neuroplasticity in multiple systems including primary auditory cortex, supramodal, and multisensory regions, to altered visual processing in congenitally deaf adults.

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Section: Discussionmentioning

confidence: 99%

Enhanced peripheral visual processing in congenitally deaf humans is supported by multiple brain regions, including primary auditory cortex

Scott

Karns

Dow

et al. 2014

Front. Hum. Neurosci.

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“…Children (age 10–18 years) with bilateral prelingual deafness had lower FA values and increased radial diffusivity bilaterally in the superior temporal gyrus, Heschl's gyrus, planum polare, and splenium of the corpus callosum compared to controls with normal hearing (Miao et al, 2013). In addition, the mean radial diffusivity of the right superior temporal gyrus appeared to be correlated with the duration of sign language use.…”

Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging in children with unilateral hearing loss: a pilot study

Rachakonda

Shimony

Coalson

et al. 2014

Front. Syst. Neurosci.

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Objective: Language acquisition was assumed to proceed normally in children with unilateral hearing loss (UHL) since they have one functioning ear. However, children with UHL score poorly on speech-language tests and have higher rates of educational problems compared to normal hearing (NH) peers. Diffusion tensor imaging (DTI) is an imaging modality used to measure microstructural integrity of brain white matter. The purpose of this pilot study was to investigate differences in fractional anisotropy (FA) and mean diffusivity (MD) in hearing- and non-hearing-related structures in the brain between children with UHL and their NH siblings.Study Design: Prospective observational cohort.Setting: Academic medical center.Subjects and Methods: Sixty one children were recruited, tested and imaged. Twenty nine children with severe-to-profound UHL were compared to 20 siblings with NH using IQ and oral language testing, and MRI with DTI. Twelve children had inadequate MRI data. Parents provided demographic data and indicated whether children had a need for an individualized educational program (IEP) or speech therapy (ST). DTI parameters were measured in auditory and non-auditory regions of interest (ROIs). Between-group comparisons were evaluated with non-parametric tests.Results: Lower FA of left lateral lemniscus was observed for children with UHL compared to their NH siblings, as well as trends toward differences in other auditory and non-auditory regions. Correlation analyses showed associations between several DTI parameters and outcomes in children with UHL. Regression analyses revealed relationships between educational outcome variables and several DTI parameters, which may provide clinically useful information for guidance of speech therapy.Discussion/Conclusion: Our data suggests that white matter microstructural patterns in several brain regions are preserved despite unilateral rather than bilateral auditory input which contrasts with findings in patients with bilateral hearing loss.

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“…Radial diffusivity (perpendicular eigenvalue, λ 23 = (λ 2 +λ 3 )/2) was calculated by averaging the maps of λ 2 and λ 3 . The standard TBSS [23,34] procedure was then applied to the data. First, all individual FA images were nonlinearly registered to the pre-defined FMRIB58_FA standard-space image provided by FSL, and affine-aligned into 1×1×1 mm MNI152 standard space.…”

Section: Methodsmentioning

confidence: 99%

Structural Abnormalities in Early Tourette Syndrome Children: A Combined Voxel-Based Morphometry and Tract-Based Spatial Statistics Study

et al. 2013

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Tourette Syndrome (TS) is characterized with chronic motor and vocal tics beginning in childhood. Abnormality of both gray (GM) and white matter (WM) has been observed in cortico-striato-thalamo-cortical circuits and sensory-motor cortex of adult TS patient. It is not clear if these morphological changes are also present in TS children and if there are any microstructural changes of WM. To understand the developmental cause of such changes, we investigated volumetric changes of GM and WM using VBM and microstructural changes of WM using DTI, and correlated these changes with tic severity and duration. T1 images and Diffusion Tensor Images (DTI) from 21 TS children were compared with 20 age and gender matched health control children using a 1.5T Philips scanner. All of the 21 TS children met the DSM-IV-TR criteria. T1 images were analyzed using DARTEL-VBM in conjunction with statistical parametric mapping (SPM). Diffusion tensor imaging (DTI) analysis was performed using Tract-Based Spatial Statistics (TBSS). Brain volume changes were found in left superior temporal gyrus, left and right paracentral gyrus, right precuneous cortex, right pre- and post- central gyrus, left temporal occipital fusiform cortex, right frontal pole, and left lingual gyrus. Significant axial diffusivity (AD) and mean diffusivity (MD) increases were found in anterior thalamic radiation, right cingulum bundle projecting to the cingulate gurus and forceps minor. Decreases in white matter volume (WMV) in the right frontal pole were inversely related with tic severity (YGTSS), and increases in AD and MD were positively correlated with tic severity and duration, respectively. These changes in TS children can be interpreted as signs of neural plasticity in response to the experiential demand. Our findings may suggest that the morphological and microstructural measurements from structural MRI and DTI can potentially be used as a biomarker of the pathophysiologic pattern of early TS children.

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Altered White Matter Integrity in Adolescents with Prelingual Deafness: A High-Resolution Tract-Based Spatial Statistics Imaging Study

Cited by 50 publications

References 37 publications

Enhanced peripheral visual processing in congenitally deaf humans is supported by multiple brain regions, including primary auditory cortex

Enhanced peripheral visual processing in congenitally deaf humans is supported by multiple brain regions, including primary auditory cortex

Diffusion tensor imaging in children with unilateral hearing loss: a pilot study

Structural Abnormalities in Early Tourette Syndrome Children: A Combined Voxel-Based Morphometry and Tract-Based Spatial Statistics Study

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