Altered vegetable intake affects pivotal carcinogenesis pathways in colon mucosa from adenoma patients and controls

Breda, Simone G. van; Agen, Ebienus van; Engels, L.G.J.B.; Moonen, E.J.C.; Kleinjans, Jos; Delft, J.H.M. van

doi:10.1093/carcin/bgh241

Cited by 22 publications

(26 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…111,118 Wark et al 40 did not observe a difference in GST enzyme activity in rectal biopsies by GSTT1 genotype. Although it is likely that vegetable intake influences gene expression in the colonic mucosa, 119 knowledge about the genes whose expression is affected is limited at present.…”

Section: Discussionmentioning

confidence: 99%

Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: A case‐control study in the Grampian region of Scotland

Little

Sharp

Masson

et al. 2006

Intl Journal of Cancer

View full text Add to dashboard Cite

Cytochrome P-450 CYP1A1 is involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs) that are derived from meat intake and tobacco smoking. Expression of the CYP1A1 gene is induced by compounds present in cruciferous vegetables. The glutathione S-transferases play a central role in the detoxification of carcinogens, including PAHs. We investigated the association between colorectal cancer and three variants (CYP1A1*2A, CYP1A1*2C, CYP1A1*4) of the CYP1A1 gene, and homozygosity for the null deletion of the GSTM1 and GSTT1 genes, and the joint effects of these genotypes and smoking, meat intake and intake of green leafy vegetables in a population-based study of 264 cases and 408 controls in Northeast Scotland. There was an inverse association with the CYP1A1*4 (m4) variant (OR 0.3, 95% CI 0.13-0.70). The OR for the CYP1A1*2C (m2) variant was 1.3 (95% CI 0.59-2.91), which is similar to a combined estimate for previous studies (OR 1.2, 95% CI 0.95-1.41). We observed no association with the CYP1A1*2A (m1) variant, or the GSTM1 and GSTT1 polymorphisms. Significant interactions between all 3 CYP1A1 variants and meat intake, and between the m1 and m2 variants and intake of green leafy vegetables, were observed. There was no evidence of interaction between CYP1A1 and smoking, and no evidence of interaction between the GSTM1 or GSTT1 polymorphisms and smoking, meat intake, green leafy vegetable intake, CYP1A1 variants or each other. ' 2006 Wiley-Liss, Inc.Key words: colorectal neoplasms; cytochrome P-450 CYP1A1; GSTM1 protein; glutathione S-transferase T1; polymorphism Evidence on the association between colorectal cancer and consumption of cooked meats, 1 tobacco smoking 2,3 and vegetable intake, 4-6 all of which are modifiable exposures with a potentially major public health impact, is inconsistent. Randomized trials 7,8 have confirmed evidence from most observational studies, [9][10][11][12] indicating an inverse relation between postmenopausal oestrogen replacement therapy and colorectal cancer, but considerable heterogeneity in the magnitude of this association was apparent. It is possible that these inconsistencies are in part due to differences between populations in the frequency of variants of genes, whose products modulate the effects of these exposures.A possible unifying factor underlying exposure to cooked meats, tobacco smoke and postmenopausal oestrogen replacement therapy is the presence of polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines. Cooking of meat and fish results in the formation of PAHs and, particularly at high temperatures, heterocyclic amines, which are carcinogenic in animals. [13][14][15] Tobacco smoking is another source of PAH exposure.16 PAHs affect oestrogen production and metabolism. 17CYP1A1 is expressed in the large bowel. 18,19 Because of the involvement of CYP1A1 in the metabolism of PAHs and oestrogens, and perhaps cruciferous vegetables and heterocyclic amines [20][21][22][23][24][25] (Table I), it might be expected that CYP1A1 variants might influence t...

show abstract

Section: Discussionmentioning

confidence: 99%

Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: A case‐control study in the Grampian region of Scotland

Little

Sharp

Masson

et al. 2006

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…In three human studies, the effect of vegetables or vegetable components on the modulation of gene or protein expression is investigated in the colon [56,58,78]. More research has been done in the field of human dietary intervention trials, in which the effect of nutritional interventions on the recurrence of precancerous polyps has been investigated.…”

Section: Indolesmentioning

confidence: 99%

“…Most studies use surrogate tissues, and only a few genes and/or proteins are investigated. The majority of studies in both colon and lungs identify changes in the expression of genes involved in apoptosis [47][48][49][50][51][52][53][54]59,64,67], cell cycle [47,48,50,52,53,63,64], cell proliferation [47,52,54,62,63,67] and/or intracellular defense and biotransformation [49,[55][56][57][58]65,67,70,72,78]. The effects of vegetables and/or vegetable components in the colon and lungs on the expression changes of genes and/or proteins involved in these four pathways are now discussed in more detail.…”

Section: Indolesmentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of colorectal and lung cancer prevention by vegetables: a genomic approach

Breda

Kok

Delft

2008

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

“…Fruits and vegetables also provide phytochemicals and vitamins such as vitamin E, folate and isothiocyanate that may have help to prevent the development of CRC by their function as antioxidants in prevention of peroxidation and/or nitrosation and by induction of defense mechanisms in the human colon (Van Breda et al, 2004). Resveratrol, found in red wine, is another phytochemical that is implicated to be protective, particularly in inhibition of metastasis (Shu et al, 2010).…”

Section: It's Not Just Meat On the Platementioning

confidence: 99%

0908 The role of red and processed meat in colorectal cancer development: A perspective

Smet¹

2016

Journal of Animal Science

View full text Add to dashboard Cite

This paper is based on a workshop held in Oslo, Norway in November 2013, in which experts discussed how to reach consensus on the healthiness of red and processed meat. Recent nutritional recommendations include reducing intake of red and processed meat to reduce cancer risk, in particular colorectal cancer (CRC). Epidemiological and mechanistic data on associations between red and processed meat intake and CRC are inconsistent and underlying mechanisms are unclear. There is a need for further studies on differences between white and red meat, between processed and whole red meat and between different types of processed meats, as potential health risks may not be the same for all products. Better biomarkers of meat intake and of cancer occurrence and updated food composition databases are required for future studies. Modifying meat composition via animal feeding and breeding, improving meat processing by alternative methods such as adding phytochemicals and improving our diets in general are strategies that need to be followed up.

show abstract

Altered vegetable intake affects pivotal carcinogenesis pathways in colon mucosa from adenoma patients and controls

Cited by 22 publications

References 25 publications

Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: A case‐control study in the Grampian region of Scotland

Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: A case‐control study in the Grampian region of Scotland

Mechanisms of colorectal and lung cancer prevention by vegetables: a genomic approach

0908 The role of red and processed meat in colorectal cancer development: A perspective

Contact Info

Product

Resources

About