Altered synchrony and loss of consciousness during frontal lobe seizures

Bonini, Francesca; Lambert, Isabelle; Wendling, Fabrice; McGonigal, Aileen; Bartolomei, Fabricē

doi:10.1016/j.clinph.2015.04.050

Cited by 23 publications

(20 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the degree of LOC was correlated with degree of synchrony in thalamocortical systems along a nonlinear curve, suggesting a bistable system. This result has been more recently extended to extratemporal seizures where a nonlinear relationship has been also observed between the level of connectivity between frontal and parietal cortex and degree of LOC.…”

Section: Network Changes and Clinical Seizure Expressionmentioning

confidence: 66%

“…That means that in these patterns, synchrony with the thalamus is higher, and effective connectivity is in favor of a leader role of the thalamus. 90 Epilepsia ILAE more recently extended to extratemporal seizures, 105,106 where a nonlinear relationship has been also observed between the level of connectivity between frontal and parietal cortex and degree of LOC.…”

Section: Network Changes and Clinical Seizure Expressionmentioning

confidence: 99%

See 1 more Smart Citation

Defining epileptogenic networks: Contribution of SEEG and signal analysis

et al. 2017

Self Cite

View full text Add to dashboard Cite

SUMMARYEpileptogenic networks are defined by the brain regions involved in the production and propagation of epileptic activities. In this review we describe the historical, methodologic, and conceptual bases of this model in the analysis of electrophysiologic intracerebral recordings. In the context of epilepsy surgery, the determination of cerebral regions producing seizures (i.e., the "epileptogenic zone") is a crucial objective. In contrast with a traditional focal vision of focal drug-resistant epilepsies, the concept of epileptogenic networks has been progressively introduced as a model better able to describe the complexity of seizure dynamics and realistically describe the distribution of epileptogenic anomalies in the brain. The concept of epileptogenic networks is historically linked to the development of the stereoelectroencephalography (SEEG) method and subsequent introduction of means of quantifying the recorded signals. Seizures, and preictal and interictal discharges produce clear patterns on SEEG. These patterns can be analyzed utilizing signal analysis methods that quantify high-frequency oscillations or changes in functional connectivity. Dramatic changes in SEEG brain connectivity can be described during seizure genesis and propagation within cortical and subcortical regions, associated with the production of different patterns of seizure semiology. The interictal state is characterized by networks generating abnormal activities (interictal spikes) and also by modified functional properties. The introduction of novel approaches to large-scale modeling of these networks offers new methods in the goal of better predicting the effects of epilepsy surgery. The epileptogenic network concept is a key factor in identifying the anatomic distribution of the epileptogenic process, which is particularly important in the context of epilepsy surgery.

show abstract

Section: Network Changes and Clinical Seizure Expressionmentioning

confidence: 66%

Section: Network Changes and Clinical Seizure Expressionmentioning

confidence: 99%

Defining epileptogenic networks: Contribution of SEEG and signal analysis

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the earlier stage of a seizure, activities of neurons at the seizure focus separate, leading the seizure focus nerves to dissociate from the inhibition of peripheral neurons and discharge with intensity [33]. Previous studies found a difference between the brain graphs of affected and unaffected hemispheres [34, 35] and compared to EEG signals from epileptic brain areas, signals recorded from epileptogenic brain areas are more uniform and nonlinear-dependent [36]. In this study, the epileptic foci are quiet in the interictal periods.…”

Section: Discussionmentioning

confidence: 99%

Epileptic foci localization based on mapping the synchronization of dynamic brain network

Tian

Wei

Chen

et al. 2019

BMC Med Inform Decis Mak

View full text Add to dashboard Cite

BackgroundCharacterizing the synchronous changes of epileptic seizures in different stages between different regions is profound to understand the transmission pathways of epileptic brain network and epileptogenic foci. There is currently no adequate quantitative calculation method for describing the propagation pathways of electroencephalogram (EEG) signals in the brain network from the short and long term. The goal of this study is to explore the innovative method to locate epileptic foci, mapping synchronization in the brain networks based on EEG.MethodsMutual information was used to analyze the short-term synchronization in the full electrodes; while nonlinear dynamics quantifies the statistical independencies in the long –term among all electrodes. Then graph theory based on the complex network was employed to construct a dynamic brain network for epilepsy patients when they were awake, asleep and in seizure, analyzing the changing topology indexes.ResultsEpileptic network achieved a high degree of nonlinear synchronization compared to awake time. and the main path of epileptiform activity was revealed by searching core nodes. The core nodes of the brain network were in connection with the onset zone. Seizures always happened with a high degree of distribution.ConclusionsThis study indicated the path of EEG synchronous propagation in seizures, and core nodes could locate the epileptic foci accurately in some epileptic patients.

show abstract

“…Of particular note is the extension of Baars "Global Workspace Theory" from the 1980s [see (237)] to neural substrates and cognitive theory. This approach has informed both cognitive and psychological ideas regarding phenomenal consciousness (see Revonsuo) or subjective awareness-a core component of consciousness-such as in the work of Dehaene [e.g., (238)], or in the sphere of SEEG studies, where this has been developed by Naccache et al (239)(240)(241)(242)(243)(244)(245)(246). This work argues, with empirical evidence, that association cortices are fundamental to phenomenal consciousness.…”

Section: Consciousnessmentioning

confidence: 99%

Cognitive and Emotional Mapping With SEEG

et al. 2021

View full text Add to dashboard Cite

Mapping of cortical functions is critical for the best clinical care of patients undergoing epilepsy and tumor surgery, but also to better understand human brain function and connectivity. The purpose of this review is to explore existing and potential means of mapping higher cortical functions, including stimulation mapping, passive mapping, and connectivity analyses. We examine the history of mapping, differences between subdural and stereoelectroencephalographic approaches, and some risks and safety aspects, before examining different types of functional mapping. Much of this review explores the prospects for new mapping approaches to better understand other components of language, memory, spatial skills, executive, and socio-emotional functions. We also touch on brain-machine interfaces, philosophical aspects of aligning tasks to brain circuits, and the study of consciousness. We end by discussing multi-modal testing and virtual reality approaches to mapping higher cortical functions.

show abstract

Altered synchrony and loss of consciousness during frontal lobe seizures

Abstract: LOC in FLE is frequent and as in other focal epilepsies is related to an alteration of prefrontal-parietal network.

Cited by 23 publications

References 22 publications

Defining epileptogenic networks: Contribution of SEEG and signal analysis

Defining epileptogenic networks: Contribution of SEEG and signal analysis

Epileptic foci localization based on mapping the synchronization of dynamic brain network

Cognitive and Emotional Mapping With SEEG

Contact Info

Product

Resources

About