Altered synaptic transmission in rat anterior cingulate cortex following peripheral nerve injury

Tachibana, Kaori; Kato, Rumiko; Tsuruga, Kenkichi; Takita, Kensuke; Hashimoto, Toshikazu; Morimoto, Yuji

doi:10.1016/j.brainres.2008.08.051

Cited by 8 publications

(4 citation statements)

References 23 publications

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“…15,26,27,87,89,136,144,167 In a recent review summarizing the work in this area over the past decade, Zhuo describes at least 4 different forms of LTP involving both pre-and postsynaptic mechanisms, including increased presynaptic glutamate release and increased postsynaptic trafficking of the GluA1 a-amino-3-hydroxy 5-methyl-4-isoxazole propionate (AMPA) receptors to the cell membrane in level V ACC pyramidal neurons. 165 Initiation and maintenance of LTP has been shown to be dependent upon increased phosphorylation of the atypical kinase, PKMz.…”

Section: Plasticity In the Accmentioning

confidence: 99%

Deep brain stimulation of the dorsal anterior cingulate cortex for the treatment of chronic neuropathic pain

Russo

Sheth

2015

FOC

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Chronic neuropathic pain is estimated to affect 3%-4.5% of the worldwide population. It is associated with significant loss of productive time, withdrawal from the workforce, development of mood disorders such as depression and anxiety, and disruption of family and social life. Current medical therapeutics often fail to adequately treat chronic neuropathic pain. Deep brain stimulation (DBS) targeting subcortical structures such as the periaqueductal gray, the ventral posterior lateral and medial thalamic nuclei, and the internal capsule has been investigated for the relief of refractory neuropathic pain over the past 3 decades. Recent work has identified the dorsal anterior cingulate cortex (dACC) as a new potential neuromodulation target given its central role in cognitive and affective processing. In this review, the authors briefly discuss the history of DBS for chronic neuropathic pain in the United States and present evidence supporting dACC DBS for this indication. They review existent literature on dACC DBS and summarize important findings from imaging and neurophysiological studies supporting a central role for the dACC in the processing of chronic neuropathic pain. The available neurophysiological and empirical clinical evidence suggests that dACC DBS is a viable therapeutic option for the treatment of chronic neuropathic pain and warrants further investigation.

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Section: Plasticity In the Accmentioning

confidence: 99%

Deep brain stimulation of the dorsal anterior cingulate cortex for the treatment of chronic neuropathic pain

Russo

Sheth

2015

FOC

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“…Thus, the motivational aspect to seek pain relief was abolished, whereas the somatosensory component of neuropathic pain was maintained after these manipulations [126, 127]. Other studies showed abnormal excitability of the ACC of rats after nerve injury or formalin-induced inflammation [128]. …”

Section: Central Nervous System (Cns)mentioning

confidence: 99%

The Perception and Endogenous Modulation of Pain

Ossipov

2012

Scientifica

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Pain is often perceived an unpleasant experience that includes sensory and emotional/motivational responses. Accordingly, pain serves as a powerful teaching signal enabling an organism to avoid injury, and is critical to survival. However, maladaptive pain, such as neuropathic or idiopathic pain, serves no survival function. Genomic studies of individuals with congenital insensitivity to pain or paroxysmal pain syndromes considerable increased our understanding of the function of peripheral nociceptors, and especially of the roles of voltage-gated sodium channels and of nerve growth factor (NGF)/TrkA receptors in nociceptive transduction and transmission. Brain imaging studies revealed a “pain matrix,” consisting of cortical and subcortical regions that respond to noxious inputs and can positively or negatively modulate pain through activation of descending pain modulatory systems. Projections from the periaqueductal grey (PAG) and the rostroventromedial medulla (RVM) to the trigeminal and spinal dorsal horns can inhibit or promote further nociceptive inputs. The “pain matrix” can explain such varied phenomena as stress-induced analgesia, placebo effect and the role of expectation on pain perception. Disruptions in these systems may account for the existence idiopathic pan states such as fibromyalgia. Increased understanding of pain modulatory systems will lead to development of more effective therapeutics for chronic pain.

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“…For example, decreased excitatory postsynaptic potentials (EPSP) within the CC are observed five days after a unilateral partial sciatic nerve ligation. 57 Tachibana et al. directly stimulated thalamic neurons, rather than with cutaneous stimuli, to evoke CC neuron EPSP.…”

Section: Discussionmentioning

confidence: 99%

“…For example, decreased excitatory postsynaptic potentials (EPSP) within the CC are observed five days after a unilateral partial sciatic nerve ligation. 57 Tachibana et al directly stimulated thalamic neurons, rather than with cutaneous stimuli, to evoke CC neuron EPSP. In contrast, eight to nine weeks after unilateral chronic constriction injury (CCI) of the sciatic nerve in mice, increased spontaneous activity was observed in CC neurons.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological modulation of brain activation to non-noxious stimulation in a cynomolgus macaque model of peripheral nerve injury

Hama¹,

Yano²,

Sotogawa³

et al. 2021

Mol Pain

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In vivo neuroimaging could be utilized as a noninvasive tool for elaborating the CNS mechanism of chronic pain and for elaborating mechanisms of potential analgesic therapeutics. A model of unilateral peripheral neuropathy was developed in the cynomolgus macaque, a species that is phylogenetically close to humans. Nerve entrapment was induced by placing a 4 mm length of polyvinyl cuff around the left common sciatic nerve. Prior to nerve injury, stimulation of the foot with a range of non-noxious von Frey filaments (1, 4, 8, 15, and 26 g) did not evoke brain activation as observed with functional magnetic resonance imaging (fMRI). Two weeks after injury, stimulation of the ipsilateral foot with non-noxious filaments activated the contralateral insula/secondary somatosensory cortex (Ins/SII) and anterior cingulate cortex (ACC). By contrast, no activation was observed with stimulation of the contralateral foot. Robust bilateral activation of thalamus was observed three to five weeks after nerve injury. Treatment with the clinical analgesic pregabalin reduced evoked activation of Ins/SII, thalamus and ACC whereas treatment with the NK1 receptor antagonist aprepitant reduced activation of the ipsilateral (left) thalamus. Twelve to 13 weeks after nerve injury, treatment with pregabalin reduced evoked activation of all regions of interest (ROI). By contrast, brain activation persisted in most ROI, except the ACC, following aprepitant treatment. Activation of the contralateral Ins/SII and bilateral thalamus was observed six months after nerve injury and pregabalin treatment suppressed activation of these nuclei. The current findings demonstrated persistent changes in CNS neurons following nerve injury as suggested by activation with non-painful mechanical stimulation. Furthermore, it was possible to functionally distinguish between a clinically efficacious analgesic drug, pregabalin, from a drug that has not demonstrated significant clinical analgesic efficacy, aprepitant. In vivo neuroimaging in the current nonhuman model could enhance translatability.

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Altered synaptic transmission in rat anterior cingulate cortex following peripheral nerve injury

Cited by 8 publications

References 23 publications

Deep brain stimulation of the dorsal anterior cingulate cortex for the treatment of chronic neuropathic pain

Deep brain stimulation of the dorsal anterior cingulate cortex for the treatment of chronic neuropathic pain

The Perception and Endogenous Modulation of Pain

Pharmacological modulation of brain activation to non-noxious stimulation in a cynomolgus macaque model of peripheral nerve injury

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