Altered Structure and Resting-State Functional Connectivity of the Basal Ganglia in Migraine Patients Without Aura

Yuan, Kai; Zhao, Ling; Cheng, Ping; Yu, Dahua; Zhao, Limei; Dong, Tao; Xing, Lihong; Bi, Yanzhi; Yang, Xuejuan; Deneen, Karen M. von; Liang, Fanrong; Gong, Qiyong; Qin, Wei; Tian, Jie

doi:10.1016/j.jpain.2013.02.010

Cited by 105 publications

(89 citation statements)

References 44 publications

(57 reference statements)

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“…In previous neuroimaging studies, the ACC was the most consistently deactivated region in PET and fMRI migraine studies [35,36], and also had a decrease in gray matter [37,38]. Our research group verified that compared with healthy controls, migraineurs showed a significant decrease in ReHo values and amplitude of low-frequency fluctuation (ALFF) in the ACC [7,9], and showed aberrant functional connectivity which had the ACC involved [8,39]. In the present study, acupunctureinduced reduction in pain intensity ratings was negatively associated with increased average ReHo values in the ACC which illustrated that acupuncture treatment could promote pain reduction successfully by modulating the migraine-affected dysfunction region, the ACC, to some extent.…”

Section: The Similarities In Resting-state Brain Activity Evoked By Asupporting

confidence: 79%

“…It was commonly revealed that there was a difference in gray matter volume in chronic pain patients compared with healthy controls [47]. The insular networks were found to be altered by migraine headache [54,55], and our research team demonstrated that migraine patients have dysfunctional connectivity involved with the insula [8,39]. We were interested in the active acupuncture-induced reduction in pain intensity ratings which were negatively associated with increased average ReHo values in the insula, as well as the ACC in the present study.…”

Section: The Potential Mechanism Of Active Acupuncture Therapy For MImentioning

confidence: 80%

“…Our research group involving migraine without aura patients showed that abnormal structure and function was possibly associated with an impaired pain processing and modulatory process, such as in the anterior cingulate cortex (ACC), insula, basal ganglia, thalamus, supplementary motor area (SMA), prefrontal cortex, etc. [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Effects of long-term acupuncture treatment on resting-state brain activity in migraine patients: A randomized controlled trial on active acupoints and inactive acupoints

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et al. 2014

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Section: The Similarities In Resting-state Brain Activity Evoked By Asupporting

confidence: 79%

Section: The Potential Mechanism Of Active Acupuncture Therapy For MImentioning

confidence: 80%

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Effects of long-term acupuncture treatment on resting-state brain activity in migraine patients: A randomized controlled trial on active acupoints and inactive acupoints

Zhao

Liu

Zhang

et al. 2014

European Journal of Integrative Medicine

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“…For each structure, a general linear fit model was generated with volume as the dependent variable, diagnosis (smokers and controls) as the categorical predictor, and intracranial volume and age as the continuous predictors. To correct for multiple comparisons, the Bonferroni correction was applied (Yuan et al, 2013b). All tests were 2-tailed, and the level of significance was p < 0.00833 (0.05/6).…”

Section: Mri Data Analysismentioning

confidence: 99%

Reduced frontal cortical thickness and increased caudate volume within fronto-striatal circuits in young adult smokers

Yuan

Cai

et al. 2015

Drug and Alcohol Dependence

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“…[7][8][9] Still others have used differences identified with voxel-based morphometry to seed ROI-based connectivity studies. [10][11][12][13] This approach has identified differences between females and males in cortical thickness and connectivity of the posterior insula and precuneus. external stimuli, 4 and primary visual and auditory networks, as well as with a region in the dorsal pons previously shown to activate ipsilaterally to pain during spontaneous and triggered migraine attacks.…”

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confidence: 99%

The anterior insula shows heightened interictal intrinsic connectivity in migraine without aura

et al. 2015

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Objective: We sought to explore whether patients with migraine show heightened interictal intrinsic connectivity within primary sensory networks, the salience network, and a network anchored by the dorsal pons, a region known to be active during migraine attacks.Methods: Using task-free fMRI and a region-of-interest analysis, we compared intrinsic connectivity patterns in 15 migraineurs without aura to 15 age-and sex-matched healthy controls, focusing on networks anchored by the calcarine cortex, Heschl gyrus, right anterior insula, and dorsal pons, a region active during migraine attacks. We also examined the relationship between network connectivity, migraine frequency, and sensory sensitivity symptoms.Results: Migraineurs showed increased connectivity between primary visual and auditory cortices and the right dorsal anterior insula, between the dorsal pons and the bilateral anterior insulae, and between the right and left ventral anterior insulae. Increased connectivity showed no clinical correlation with migraine frequency or sensory sensitivity. Conclusions:Patients with migraine display interictal changes in the topology of intrinsic connections, with greater connectivity between primary sensory cortices, the pons, and the anterior insula, a region involved in representing and coordinating responses to emotional salience. Migraine is a common, disabling primary headache disorder whose pathophysiology is incompletely understood.1 Migraine attacks often feature an alteration in sensory processing such that normally well-tolerated stimuli become unpleasant, manifesting most frequently as photophobia and phonophobia. These sensory changes may persist between attacks, as migraineurs have lower interictal thresholds for light-and sound-induced discomfort than controls. 2,3Task-free fMRI identifies brain regional ensembles, termed intrinsic connectivity networks (ICNs), 4 that exhibit correlated low-frequency blood oxygen level-dependent signal fluctuations. Previous task-free fMRI studies using independent component analysis revealed altered connectivity of the "executive," "default mode," and "salience" ICNs in migraineurs, although the direction of changes differed between studies. 5,6 Other studies used region-of-interest (ROI) analysis, focusing on pain-related regions such as the periaqueductal gray or amygdala and found increased connectivity in these networks. [7][8][9] Still others have used differences identified with voxel-based morphometry to seed ROI-based connectivity studies. [10][11][12][13] This approach has identified differences between females and males in cortical thickness and connectivity of the posterior insula and precuneus. 12 We studied interictal migraineurs with task-free fMRI to evaluate ICNs relevant to primary sensory processing, nociception, and salience. Given the increased salience of sensory stimuli in migraineurs, we hypothesized that migraineurs would have increased connectivity between the salience network, thought to be involved in identifying homeostatically releva...

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Altered Structure and Resting-State Functional Connectivity of the Basal Ganglia in Migraine Patients Without Aura

Cited by 105 publications

References 44 publications

Effects of long-term acupuncture treatment on resting-state brain activity in migraine patients: A randomized controlled trial on active acupoints and inactive acupoints

Effects of long-term acupuncture treatment on resting-state brain activity in migraine patients: A randomized controlled trial on active acupoints and inactive acupoints

Reduced frontal cortical thickness and increased caudate volume within fronto-striatal circuits in young adult smokers

The anterior insula shows heightened interictal intrinsic connectivity in migraine without aura

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