Altered Spontaneous Activity and Functional Connectivity in the Posterior Pons of Patients With Migraine Without Aura

Qin, Zhaoxia; He, Xianghuo; Zhang, Jilei; Xu, Shuai; Li, Gefei; Su, Jingjing; Shi, Yan-Hui; Ban, Shiyu; Hu, Yue; Liu, Yi‐Sheng; Zhuang, Mei-Ting; Zhao, Rong; Shen, Xiaolei; Li, Jianqi; Liu, Jian-Ren; Du, Xiaoxia

doi:10.1016/j.jpain.2019.08.001

Cited by 11 publications

(18 citation statements)

References 30 publications

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“…Supporting our result, abnormal brain structure and function of this region in both CM and EM patients have been reported in previous MRI studies on migraine. [29][30][31][32] In both CM and EM, the causal flow from the bilateral visual areas to bilateral hippocampus significantly decreased (increased negative influence), suggesting that…”

Section: Discussionmentioning

confidence: 99%

Alterations in Effective Connectivity of the Hippocampus in Migraine without Aura

Zhu¹,

Dai²,

Zhao³

et al. 2021

JPR

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Neuroimaging studies on migraine have revealed structural and functional alterations in the hippocampus, a region involved in pain processing and stress response. This study was designed to investigate whether effective connectivity of this region is disrupted in migraine and relates to chronicity of this disease. Patients and Methods: In 39 episodic migraine (EM) patients, 17 chronic migraine (CM) patients, and 35 healthy controls, we investigated differences in the directional influences between the hippocampus and the rest of the brain by combining resting-state functional magnetic resonance imaging and Granger causality analysis (GCA), with bilateral hippocampus as seed regions. The associations between directional influences and the clinical variables were also examined. Results: Comparing each patient group to the control group, we found increased and decreased negative influence on the hippocampus exerted by the bilateral visual areas and right dorsolateral prefrontal cortex (dlPFC), respectively. The hippocampus showed increased positive influence on the right posterior insula and medial prefrontal cortex (mPFC), as well as increased negative influence on the left cerebellum in CM patients relative to EM patients and healthy controls. Furthermore, across all patients, the migraine frequency exhibited a positive and negative association with causal influence from the hippocampus to mPFC and left cerebellum, respectively. Conclusion: Migraine patients have abnormal effective connectivity between the hippocampus and multiple brain regions involved in the sensory and cognitive processing of pain. Disrupted directional influences to the hippocampus exerted by dlPFC and bilateral visual areas were common features of EM and CM patients. Directional influences from the hippocampus to mPFC and left cerebellum may be useful imaging biomarkers for assessing migraine frequency.

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Section: Discussionmentioning

confidence: 99%

Alterations in Effective Connectivity of the Hippocampus in Migraine without Aura

Zhu¹,

Dai²,

Zhao³

et al. 2021

JPR

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“…A decreased gyrification index in the left rostral MFG was found in MWoAs [51]. MWoAs in the interictal phase showed significantly weaker FC between the posterior pons and left MFG [52]. The frequency of migraine attacks and the duration of the disorder had a significant impact on cortical thickness in the sensorimotor cortex and MFG [53].…”

Section: Discussionmentioning

confidence: 99%

Altered resting‐state functional connectivity between subregions in the thalamus and cortex in migraine without aura

Qin

et al. 2020

Euro J of Neurology

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Background and purpose: Migraine is a complex and disabling neurological disorder, the exact neurological mechanisms of which remain unclear. The thalamus is considered to be the hub of the central processing and integration of nociceptive information, as well as the modulation of these processes. Methods: A total of 48 migraineurs without aura (MWoAs) during the interictal phase and 48 age-and sex-matched healthy controls underwent restingstate functional magnetic resonance imaging scans. We utilized masked independent component analysis and seed-based functional connectivity (FC) to investigate whether MWoAs exhibited abnormal FC between subregions in the thalamus and the cortex regions. Results: The MWoAs showed significantly weaker FC between the anterior dorsal thalamic nucleus and left precuneus. Additionally, MWoAs exhibited significantly reduced FC between the ventral posterior nucleus (VPN) and left precuneus, right inferior parietal lobule (R-IPL) and right middle frontal gyrus. Furthermore, the FC Z-scores between the VPN and R-IPL were negatively correlated with pain intensity in MWoAs. The disease duration of patients was negatively correlated with the FC Z-scores between the VPN and R-IPL. Conclusion: These altered thalamocortical connectivity patterns may contribute to multisensory integration abnormalities, deficits in pain attention, cognitive evaluation and pain modulation. Pain sensitivity and disease duration are closely tied to abnormal FC between the VPN and R-IPL. Remarkably, recurrent headache attacks might contribute to this maladaptive functional plasticity closely related to pain intensity.

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“…In a previous positron emission tomography with computed tomography study, the migraine group had decreased glucose metabolism in several contralateral brain regions including the superior parietal lobe [38]. In fact, it has been proposed that the superior parietal lobe is involved in the sensory discrimination of pain information [30, 39]. Thus, impaired connectivity related to the superior parietal lobe may disrupt the pathway used to discriminate the sensory features of pain and induce hypersensitivity to pain stimuli in migraineurs.…”

Section: Discussionmentioning

confidence: 99%

Altered functional connectivity of the red nucleus and substantia nigra in migraine without aura

et al. 2019

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Background: Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. Accumulating evidence is pointing toward malfunctioning of brainstem structures, i.e., the red nucleus (RN) and substantia nigra (SN), as an important factor in migraine without aura (MwoA). We aimed to identify atypical FC between the RN and SN and other brain areas in patients with MwoA and to explore the association between RN and SN connectivity changes and performance on neuropsychological tests in these patients. Methods: Resting-state functional magnetic resonance imaging (fMRI) data were obtained from 30 patients with MwoA and 22 age-, sex-, and years of education-matched healthy controls (HC). The FC of the brainstem structures was analyzed using a standard seed-based whole-brain correlation method. The results of the brainstem structure FC were assessed for correlations with other clinical features. Results: Patients with MwoA exhibited reduced left RN-based FC with the left middle frontal gyrus, reduced right RNbased FC with the ipsilateral superior parietal lobe, and increased FC with the ipsilateral cerebellum. Additionally, patients with MwoA demonstrated significantly decreased right SN-based FC with the right postcentral gyrus, left parietal lobule, and left superior frontal gyrus. Hypo-connectivity between the right SN and right postcentral gyrus was negatively correlated with disease duration (r = − 0.506, P = 0.004). Additionally, increased connectivity of the right RN to the ipsilateral cerebellar lobes was positively correlated with the Headache Impact Test-6 scores (r = 0.437, P = 0.016). Conclusions: The present study suggested that patients with MwoA have disruption in their RN and SN resting-state networks, which are associated with specific clinical characteristics. The changes focus on the regions associated with cognitive evaluation, multisensory integration, and modulation of perception and pain, which may be associated with migraine production, feedback, and development. Taken together, these results may improve our understanding of the neuropathological mechanism of migraine.

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Altered Spontaneous Activity and Functional Connectivity in the Posterior Pons of Patients With Migraine Without Aura

Cited by 11 publications

References 30 publications

Alterations in Effective Connectivity of the Hippocampus in Migraine without Aura

Alterations in Effective Connectivity of the Hippocampus in Migraine without Aura

Altered resting‐state functional connectivity between subregions in the thalamus and cortex in migraine without aura

Altered functional connectivity of the red nucleus and substantia nigra in migraine without aura

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