Altered spermatogenesis, steroidogenesis and suppressed fertility in adult male rats exposed to genistein, a non-steroidal phytoestrogen during embryonic development

Meena, Ramovatar; Supriya, Ch.; Reddy, K. Pratap; Reddy, P. Sreenivasula

doi:10.1016/j.fct.2016.11.020

Cited by 35 publications

(32 citation statements)

References 38 publications

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“…These findings are directly affected by the amount of Sertoli cell and indirectly from tempeh ethanol extract intervention. This phenomenon is in accordance with the evidence of intervention of genistein in pregnancy period of day-12 until day-19 could hamper spermatozoa production [24].…”

Section: Discussionsupporting

confidence: 74%

Changes in Male Reproductive System Induced by Tempeh Ethanol Extract Administered to Rats From Prenatal Until Weaning Period of Life

Satriyasa

Ni²,

Karmaya

2018

Asian J Pharm Clin Res

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Objective: Sertoli cell and spermatogonia are formed in the prenatal period, and alterations information process could affect the reproduction function in the adolescence and adult period. This study aimed to unveil the effect of tempeh's isoflavone that was given from prenatal to weaning during childhood period toward the amount of Sertoli cell and spermatogonia. Method:The study design was randomized post-test only control group design with 15 female Wistar experimental mouse in the aged of 12 th -13 th weeks was used and divided into three groups, namely, control groups (C) that were given aquadest, intervention Group 1 (I1) and intervention Group 2 (I2) that was given tempeh 0.5 g/kg body weight/day ethanol extract that contains 0.52 mg genistein and 5 g/kg body weight/day that contains 5.2 mg genistein, respectively. The intervention was given for a week before copulation, during pregnancy and lactation period. The observed parameters were Sertoli cell and spermatogonia of an early-born mouse. Result:The amount of Sertoli cell and spermatogonia were different between the three groups (p<0.05). The I2 group has the lowest amount of Sertoli cell and spermatogonia and shows a significant difference from the control group as well as I1 (p<0.05). Tempeh ethanol extract has a direct impact on reducing the amount of Sertoli cell to about 11% lower than control. It also affected the number of spermatogonia indirectly through its effect toward Sertoli cells. Conclusion:Intervention of tempeh ethanol extract to female Wistar experimental mouse from prenatal period to weaning child period could disturb the formation of Sertoli cell and spermatogonia of the early-born mouse.

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Section: Discussionsupporting

confidence: 74%

Changes in Male Reproductive System Induced by Tempeh Ethanol Extract Administered to Rats From Prenatal Until Weaning Period of Life

Satriyasa

Ni²,

Karmaya

2018

Asian J Pharm Clin Res

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“…The mated females were allowed to complete the term for litters. Mating (mating index (%) = number of vaginal plug‐positive females/number of pairings × 100) and fertility (fertility index (%) = number of pregnant females/number of vaginal plug‐positive females × 100) indices were evaluated and number of litters was recorded (Meena, Supriya, Pratap Reddy, & Sreenivasula Reddy, ; Nelli & Pamanji, ).…”

Section: Methodsmentioning

confidence: 99%

“…Mating ( indices were evaluated and number of litters was recorded (Meena, Supriya, Pratap Reddy, & Sreenivasula Reddy, 2017;Nelli & Pamanji, 2017).…”

Section: Fertility Studiesmentioning

confidence: 99%

Chronic exposure to perfluorononanoic acid impairs spermatogenesis, steroidogenesis and fertility in male mice

Singh

2018

J of Applied Toxicology

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Perfluoroalkyl acids (PFAAs) are widely used in commercial applications and that they are ubiquitous and persistent in the environment. Perfluorononanoic acid (PFNA), a member of PFAAs, has been detected in human and wildlife. Previous acute exposure studies have shown the adverse effect of PFNA on the testis. The present study was aimed to examine the effect of chronic PFNA exposure, from prepuberty to adulthood, on testicular functions and fertility in Parkes (P) male mice and to investigate the possible mechanism(s) of its action. PFNA (0.2 and 0.5 mg/kg) was orally administered to P male mice for 90 days from prepuberty (postnatal day [PND] 25) to adulthood (PND 114). Histologically, testes in PFNA‐treated mice showed non‐uniform degenerative changes in the seminiferous tubules. The treatment also had adverse effects on testicular expression of steroidogenic markers, serum levels of cholesterol and testosterone, sperm parameters and on litter size. A marked increase in the level of lipid peroxidation and decrease in the activities of antioxidant enzymes were observed in the testis of PFNA‐treated mice compared to controls. Further, a significant decrease in expression of proliferating cell nuclear antigen (PCNA) and in the number of PCNA‐positive cells, and an increase in expression of caspase‐3 were also noted in PFNA‐treated mice testis. In conclusion, the results suggest that chronic exposure to PFNA in male mice interferes with testosterone biosynthesis and causes oxidative stress in the testis, leading to alterations in spermatogenesis, sperm quality and fertility potential.

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“…In general, some studies have implied that there is an antioxidant potential role of soy isoflavones for improving the inflammatory and oxidative effects of BPA on the gonad (Zhang et al 2014;Bernardo et al 2015), and thus soy isoflavones can maintain proper function of the male reproductive system. In contrary, a few studies have also indicated isoflavones reduced fertility and sperm quality along with a possibly antiandrogenic effect (Meena et al 2017) that cannot be ignored in this context.…”

Section: Discussionmentioning

confidence: 94%

Co-exposure to endocrine disruptors: effect of bisphenol A and soy extract on glucose homeostasis and related metabolic disorders in male mice

Veissi

Jafarirad

Ahangarpour

et al. 2018

Endocrine Regulations

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Altered spermatogenesis, steroidogenesis and suppressed fertility in adult male rats exposed to genistein, a non-steroidal phytoestrogen during embryonic development

Cited by 35 publications

References 38 publications

Changes in Male Reproductive System Induced by Tempeh Ethanol Extract Administered to Rats From Prenatal Until Weaning Period of Life

Changes in Male Reproductive System Induced by Tempeh Ethanol Extract Administered to Rats From Prenatal Until Weaning Period of Life

Chronic exposure to perfluorononanoic acid impairs spermatogenesis, steroidogenesis and fertility in male mice

Co-exposure to endocrine disruptors: effect of bisphenol A and soy extract on glucose homeostasis and related metabolic disorders in male mice

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