Altered specificity of 15-LOX-1 in the biosynthesis of 7S,14S-diHDHA implicates 15-LOX-2 in biosynthesis of resolvin D5

Perry, Steve; Kalyanaraman, Chakrapani; Tourdot, Benjamin E.; Conrad, William S.; Akinkugbe, Oluwayomi; Freedman, John C.; Holinstat, Michael; Jacobson, Matthew P.; Holman, Theodore R.

doi:10.1101/2020.03.25.008573

2020

DOI: 10.1101/2020.03.25.008573

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Altered specificity of 15-LOX-1 in the biosynthesis of 7S,14S-diHDHA implicates 15-LOX-2 in biosynthesis of resolvin D5

Steve Perry

Chakrapani Kalyanaraman

Benjamin E. Tourdot

et al.

Abstract: Running title: Altered positional specificity of h15-LOX-1 with 7-HDHA

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Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases

Offenbacher

Holman

2020

Molecules

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Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important mediators for cell signaling and inflammation. These reactions are initiated by a C-H activation step that is allosterically regulated in plant and animal enzymes. LOXs from higher eukaryotes are equipped with an N-terminal PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain that has been implicated to bind to small molecule allosteric effectors, which in turn modulate substrate specificity and the rate-limiting steps of catalysis. Herein, the kinetic and structural evidence that describes the allosteric regulation of plant and animal lipoxygenase chemistry by fatty acids and their derivatives are summarized.

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Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases

Offenbacher

Holman

2020

Molecules

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Altered specificity of 15-LOX-1 in the biosynthesis of 7S,14S-diHDHA implicates 15-LOX-2 in biosynthesis of resolvin D5

Abstract: Running title: Altered positional specificity of h15-LOX-1 with 7-HDHA

Cited by 1 publication

References 81 publications

Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases

Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases

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