Altered social cognition and connectivity of default mode networks in the co-occurrence of autistic spectrum disorder and attention deficit hyperactivity disorder

Wang, Kai; Xu, Mingyu; Ji, Yiting; Zhang, Lingli; Du, Xuesen; Li, Jijun; Luo, Qiang; Li, Fēi

doi:10.1177/0004867419836031

Cited by 19 publications

(27 citation statements)

References 53 publications

(59 reference statements)

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“…Figure 1 provides a schematic representation of findings from all the studies for each group, with yellow dots representing the DMN hub regions, blue (underconnected) or red (overconnected) dots representing connectivity with other brain regions, and thickness of lines connecting the dots representing frequency of findings across studies in each group. Here, we see that studies examining within-DMN connectivity (intra-DMN) found underconnectivity involving the posterior hub of the DMN or between the anterior and posterior hubs of the DMN more frequently in ASD (77,78,80,82,83,85,87,88,90,91,97,102,103), while overconnectivity involving the anterior hub or between the anterior and posterior hubs of the DMN was often found in EOP studies (105,109,112,113,117). Some studies reported intra-DMN underconnectivity in EOP involving the posterior hub of the DMN or between the medial and lateral hubs of the DMN (106,108,110,117).…”

Section: Dmn Connectivity In Adolescents With Eopmentioning

confidence: 71%

A Review of Default Mode Network Connectivity and Its Association With Social Cognition in Adolescents With Autism Spectrum Disorder and Early-Onset Psychosis

et al. 2020

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Recent studies have demonstrated substantial phenotypic overlap, notably social impairment, between autism spectrum disorder (ASD) and schizophrenia. However, the neural mechanisms underlying the pathogenesis of social impairments across these distinct neuropsychiatric disorders has not yet been fully examined. Most neuroimaging studies to date have focused on adults with these disorders, with little known about the neural underpinnings of social impairments in younger populations. Here, we present a narrative review of the literature available through April 2020 on imaging studies of adolescents with either ASD or early-onset psychosis (EOP), to better understand the shared and unique neural mechanisms of social difficulties across diagnosis from a developmental framework. We specifically focus on functional connectivity studies of the default mode network (DMN), as the most extensively studied brain network relevant to social cognition across both groups. Our review included 29 studies of DMN connectivity in adolescents with ASD (Mean age range = 11.2-21.6 years), and 14 studies in adolescents with EOP (Mean age range = 14.2-24.3 years). Of these, 15 of 29 studies in ASD adolescents found predominant underconnectivity when examining DMN connectivity. In contrast, findings were mixed in adolescents with EOP, with five of 14 studies reporting DMN underconnectivity, and an additional six of 14 studies reporting both under-and over-connectivity of the DMN. Specifically, intra-DMN networks were more frequently underconnected in ASD, but overconnected in EOP. On the other hand, inter-DMN connectivity patterns were mixed (both under-and over-connected) for each group, especially DMN connectivity with frontal, sensorimotor, and temporoparietal regions in ASD, and with frontal, temporal, subcortical, and cerebellar regions in EOP. Finally, disrupted DMN connectivity appeared to be associated with social impairments in both groups, less so with other features distinct to each condition, such as repetitive behaviors/restricted interests in ASD and hallucinations/delusions in EOP. Further studies on demographically well-matched groups of adolescents with each of these conditions

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Section: Dmn Connectivity In Adolescents With Eopmentioning

confidence: 71%

A Review of Default Mode Network Connectivity and Its Association With Social Cognition in Adolescents With Autism Spectrum Disorder and Early-Onset Psychosis

et al. 2020

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“…Approximately 52% of the studies in adolescents with ASD presented in our review (Table 1 and 2) have utilized the ABIDE dataset to investigate DMN connectivity (Nielsen et al, 2014;Nomi and Uddin, 2015;Elton et al, 2016;Falahpour et al, 2016;Ypma et al, 2016;Chen et al, 2017;Guo et al, 2017;Bi et al, 2018;Kernbach et al, 2018;Borras-Ferris et al, 2019;Guo et al, 2019;Lawrence et al, 2019;Reiter et al, 2019;Wang et al, 2019a). About half of the studies (15 out of 29) in adolescents with ASD have found a global pattern of underconnectivity both within the DMN hubs (Assaf et al, 2010;Weng et al, 2010;Starck et al, 2013;Falahpour et al, 2016;Ypma et al, 2016;Neufeld et al, 2018;Borras-Ferris et al, 2019;Reiter et al, 2019), as well as between the DMN and other brain regions such as insula, subcortical regions, fronto-parietal regions, and visual cortex (Wiggins et al, 2011;Nielsen et al, 2014;Nomi and Uddin, 2015;Kernbach et al, 2018;Guo et al, 2019), regardless of analytic methods used.…”

Section: Dmn Connectivity In Adolescents With Asdmentioning

confidence: 99%

“…Relatively fewer studies (five out of 29) have observed over-connectivity between the DMN and task-positive regions within the frontoparietal, visual, and sensorimotor regions, as well as the salience network (Redcay et al, 2013;Elton et al, 2016;Hogeveen et al, 2018;Gao et al, 2019;Mash et al, 2019). Some studies (nine out of 29) have additionally found mixed patterns involving under-and over-connectivity of ASD youth relative to typically developing (TD) controls, largely highlighting a pattern of within-DMN underconnectivity, with overconnectivity between DMN and other networks such as task-positive or sensorimotor networks (Doyle-Thomas et al, 2015;Jann et al, 2015;Abbott et al, 2016;Chen et al, 2017;Guo et al, 2017;Joshi et al, 2017;Bi et al, 2018;Pereira et al, 2018;Lawrence et al, 2019;Wang et al, 2019a). This mixed pattern of connectivity may suggest poor integration within the DMN, along with atypical segregation between the DMN and other related cognitive networks in adolescents with ASD (see Table 2 for main results from each study).…”

Section: Dmn Connectivity In Adolescents With Asdmentioning

confidence: 99%

“…Most of the studies included in this review focused on adolescents within the normative intellectual functioning range; however, one recent study (Mash et al, 2018) Lord, 1999;, the Autism Diagnostic Interview-Revised (ADI-R; Rutter, 2003), and the Social Responsiveness Scale (SRS; Constantino, 2005;. Studies looking at the association of within-DMN network connectivity with behavioral measures of symptom severity (N=6 studies) found mixed effects, with most (five out of six studies) reporting greater within-DMN network underconnectivity associated with higher social impairment scores on the ADOS (Assaf et al, 2010;), ADI-R (Weng et al, 2010;Wang et al, 2019a), and SRS (Assaf et al, 2010); while one of the six found greater within-DMN overconnectivity to be associated with higher social impairment scores on the SRS (Jann et al, 2015), and one (using the ADOS) reporting a mixed pattern (Guo et al, 2017) . Studies looking at the association of DMN between-network connectivity with behavioral measures of symptom severity (N=7) mostly found that greater overconnectivity between DMN and other brain regions (mostly in the frontal and temporal lobes; four out of seven studies) was associated with higher social impairments on the ADOS (Chen et al, 2017), ADI-R (trend level; (Pereira et al, 2018), and SRS (Abbott et al, 2016;Elton et al, 2016).…”

Section: Dmn Connectivity In Adolescents With Asdmentioning

confidence: 99%

“…Additionally, Doyle-Thomas et al 2015and Ypma et al (2016) found that anomalous DMN connectivity patterns in adolescents with ASD (mixed within-DMN connectivity results in the former study, and within-DMN underconnectivity in the latter study) were associated with poorer performance on the "Reading the Mind in the Eyes" Test (RMET; Baron-Cohen et al, 2001), a measure of theory of mind (ToM) and social cognition. Of the studies (all 12 reporting associations between DMN connectivity and behavioral measures of symptom severity) that looked at both the social interaction domain and the repetitive behaviors/restricted interests domain of the ADOS-2 and ADI-R (Assaf et al, 2010;Weng et al, 2010;Redcay et al, 2013;Jann et al, 2015;Abbott et al, 2016;Elton et al, 2016;Chen et al, 2017;Guo et al, 2017;Pereira et al, 2018;Guo et al, 2019;Wang et al, 2019a), only one study (Weng et al, 2010) reported a significant relationship for DMN within-network underconnectivity patterns and measures of repetitive behaviors/ restricted interests (ADI-R) in ASD adolescents. Hence, it appears that aberrant DMN connectivity may play a larger role in the social functioning deficits experienced by this population rather than other features of ASD.…”

Section: Dmn Connectivity In Adolescents With Asdmentioning

confidence: 99%

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A review of default mode network connectivity and its association with social cognition in adolescents with autism spectrum disorder and early-onset psychosis

Nair¹,

Jolliffe²,

Lograsso³

et al. 2020

Preprint

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Recent studies have demonstrated substantial phenotypic overlap, notably social impairment, between autism spectrum disorder (ASD) and schizophrenia. However, the neural mechanisms underlying the pathogenesis of social impairments across these distinct neuropsychiatric disorders has not yet been fully examined. Most neuroimaging studies to date have focused on adults with these disorders, with little known about the neural underpinnings of social impairments in younger populations. Here, we review the literature available through March 2020 on imaging studies of adolescents with either ASD or early-onset psychosis (EOP), to better understand the shared and unique neural mechanisms of social difficulties across diagnosis from a developmental framework. We specifically focus on functional connectivity studies of the default mode network (DMN), as the most extensively studied brain network relevant to social cognition across both groups. Our review included 29 studies of DMN connectivity in adolescents with ASD (Mean age range = 11.2-21.6 years), and 14 studies in adolescents with EOP (Mean age range = 14.2-24.3 years). Of these, 15 of 29 studies in ASD adolescents found predominant underconnectivity when examining DMN connectivity. In contrast, findings were mixed in adolescents with EOP, with five of 14 studies reporting DMN underconnectivity, and an additional six of 14 studies reporting both under- and over-connectivity of the DMN. Specifically, intra-DMN networks were more frequently underconnected in ASD, but overconnected in EOP. On the other hand, inter-DMN connectivity patterns were mixed (both under- and over-connected) for each group, especially DMN connectivity with frontal, sensorimotor, and temporoparietal regions in ASD, and with frontal, temporal, subcortical, and cerebellar regions in EOP. Finally, disrupted DMN connectivity appeared to be associated with social impairments in both groups, less so with other features distinct to each condition, such as repetitive behaviors/restricted interests in ASD and hallucinations/ delusions in EOP. Further studies on demographically well-matched groups of adolescents with each of these conditions are needed to systematically explore additional critical contributing factors in DMN connectivity patterns such as clinical heterogeneity, pubertal development, and medication effects that would better inform treatment targets and facilitate prediction of social outcomes in the context of these developmental neuropsychiatric conditions.

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Where do neurodevelopmental conditions fit in transdiagnostic psychiatric frameworks? Incorporating a new neurodevelopmental spectrum

Michelini,

Carlisi,

Eaton

et al. 2024

World Psychiatry

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Features of autism spectrum disorder, attention‐deficit/hyperactivity disorder, learning disorders, intellectual disabilities, and communication and motor disorders usually emerge early in life and are associated with atypical neurodevelopment. These “neurodevelopmental conditions” are grouped together in the DSM‐5 and ICD‐11 to reflect their shared characteristics. Yet, reliance on categorical diagnoses poses significant challenges in both research and clinical settings (e.g., high co‐occurrence, arbitrary diagnostic boundaries, high within‐disorder heterogeneity). Taking a transdiagnostic dimensional approach provides a useful alternative for addressing these limitations, accounting for shared underpinnings across neurodevelopmental conditions, and characterizing their common co‐occurrence and developmental continuity with other psychiatric conditions. Neurodevelopmental features have not been adequately considered in transdiagnostic psychiatric frameworks, although this would have fundamental implications for research and clinical practices. Growing evidence from studies on the structure of neurodevelopmental and other psychiatric conditions indicates that features of neurodevelopmental conditions cluster together, delineating a “neurodevelopmental spectrum” ranging from normative to impairing profiles. Studies on shared genetic underpinnings, overlapping cognitive and neural profiles, and similar developmental course and efficacy of support/treatment strategies indicate the validity of this neurodevelopmental spectrum. Further, characterizing this spectrum alongside other psychiatric dimensions has clinical utility, as it provides a fuller view of an individual's needs and strengths, and greater prognostic utility than diagnostic categories. Based on this compelling body of evidence, we argue that incorporating a new neurodevelopmental spectrum into transdiagnostic frameworks has considerable potential for transforming our understanding, classification, assessment, and clinical practices around neurodevelopmental and other psychiatric conditions.

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Altered social cognition and connectivity of default mode networks in the co-occurrence of autistic spectrum disorder and attention deficit hyperactivity disorder

Cited by 19 publications

References 53 publications

A Review of Default Mode Network Connectivity and Its Association With Social Cognition in Adolescents With Autism Spectrum Disorder and Early-Onset Psychosis

A Review of Default Mode Network Connectivity and Its Association With Social Cognition in Adolescents With Autism Spectrum Disorder and Early-Onset Psychosis

A review of default mode network connectivity and its association with social cognition in adolescents with autism spectrum disorder and early-onset psychosis

Where do neurodevelopmental conditions fit in transdiagnostic psychiatric frameworks? Incorporating a new neurodevelopmental spectrum

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