Altered small-world properties of gray matter networks in breast cancer

Hosseini, S. M. Hadi; Koovakkattu, Della; Kesler, Shelli R.

doi:10.1186/1471-2377-12-28

Cited by 84 publications

(107 citation statements)

References 61 publications

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“…BC chemotherapy is associated with widespread reductions in white matter pathway integrity in similar regions, including cingulum and superior frontal occipital fasciculus (15,16). A previous study from our laboratory demonstrated disorganization of large-scale structural brain networks following BC chemotherapy, including reduced participation of precuneus in the network (17). These neuroimaging findings are supported by animal studies that demonstrate chronic suppression of hippocampal neurogenesis as well as white matter myelin damage following administration of systemic chemotherapeutic agents (1,18).…”

supporting

confidence: 69%

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Kesler

Wefel²,

Hosseini

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

105

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Breast cancer (BC) chemotherapy is associated with cognitive changes including persistent deficits in some individuals. We tested the accuracy of default mode network (DMN) resting state functional connectivity patterns in discriminating chemotherapy treated (C+) from non–chemotherapy (C−) treated BC survivors and healthy controls (HC). We also examined the relationship between DMN connectivity patterns and cognitive function. Multivariate pattern analysis was used to classify 30 C+, 27 C−, and 24 HC, which showed significant accuracy for discriminating C+ from C− (91.23%, P < 0.0001) and C+ from HC (90.74%, P < 0.0001). The C− group did not differ significantly from HC (47.06%, P = 0.60). Lower subjective memory function was correlated ( P < 0.002) with greater hyperplane distance (distance from the linear decision function that optimally separates the groups). Disrupted DMN connectivity may help explain long-term cognitive difficulties following BC chemotherapy.

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supporting

confidence: 69%

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Kesler

Wefel²,

Hosseini

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

105

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“…We have previously observed altered structural and functional clustered connectivity in our cross‐sectional studies of chemotherapy‐treated, long‐term breast cancer survivors (Bruno et al., 2012; Hosseini, Koovakkattu, & Kesler, 2012; Kesler et al., 2015). In the present study, we demonstrated only very subtle disruption of local clustered connectivity in pretreatment patients.…”

Section: Discussionmentioning

confidence: 99%

Disrupted brain network functional dynamics and hyper‐correlation of structural and functional connectome topology in patients with breast cancer prior to treatment

et al. 2017

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IntroductionSeveral previous studies have demonstrated that cancer chemotherapy is associated with brain injury and cognitive dysfunction. However, evidence suggests that cancer pathogenesis alone may play a role, even in non‐CNS cancers.MethodsUsing a multimodal neuroimaging approach, we measured structural and functional connectome topology as well as functional network dynamics in newly diagnosed patients with breast cancer. Our study involved a novel, pretreatment assessment that occurred prior to the initiation of any cancer therapies, including surgery with anesthesia. We enrolled 74 patients with breast cancer age 29–65 and 50 frequency‐matched healthy female controls who underwent anatomic and resting‐state functional MRI as well as cognitive testing.ResultsCompared to controls, patients with breast cancer demonstrated significantly lower functional network dynamics (p = .046) and cognitive functioning (p < .02, corrected). The breast cancer group also showed subtle alterations in structural local clustering and functional local clustering (p < .05, uncorrected) as well as significantly increased correlation between structural global clustering and functional global clustering compared to controls (p = .03). This hyper‐correlation between structural and functional topologies was significantly associated with cognitive dysfunction (p = .005).ConclusionsOur findings could not be accounted for by psychological distress and suggest that non‐CNS cancer may directly and/or indirectly affect the brain via mechanisms such as tumor‐induced neurogenesis, inflammation, and/or vascular changes, for example. Our results also have broader implications concerning the importance of the balance between structural and functional connectome properties as a potential biomarker of general neurologic deficit.

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“…This organization putatively allows the brain to balance the opposing demands of segregation and integration, providing high capacity for parallel information processing with minimal wiring cost (Bassett and Bullmore, 2006). We have previously demonstrated altered organization of gray matter structural and intrinsic functional connectomes in breast cancer survivors (Bruno, et al, 2012; Hosseini, et al, 2012b). For the present study, we expand upon these findings by using DTI-based connectome graphs to evaluate the brain network's tolerance to simulated neurodegeneration.…”

Section: Introductionmentioning

confidence: 99%

Brain network alterations and vulnerability to simulated neurodegeneration in breast cancer

Kesler¹,

Watson²,

Blayney³

2015

Neurobiology of Aging

107

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Breast cancer and its treatments are associated with mild cognitive impairment and brain changes that could indicate an altered or accelerated brain aging process. We applied diffusion tensor imaging (DTI) and graph theory to measure white matter organization and connectivity in 34 breast cancer survivors compared to 36 matched healthy female controls. We also investigated how brain networks (connectomes) in each group responded to simulated neurodegeneration based on network attack analysis. Compared to controls, the breast cancer group demonstrated significantly lower fractional anisotropy (FA), altered small-world connectome properties, lower brain network tolerance to systematic region (node) and connection (edge) attacks and significant cognitive impairment. Lower tolerance to network attack was associated with cognitive impairment in the breast cancer group. These findings provide further evidence of diffuse white matter pathology following breast cancer and extend the literature in this area with unique data demonstrating increased vulnerability of the post-breast cancer brain network to future neurodegenerative processes.

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Altered small-world properties of gray matter networks in breast cancer

Cited by 84 publications

References 61 publications

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Disrupted brain network functional dynamics and hyper‐correlation of structural and functional connectome topology in patients with breast cancer prior to treatment

Brain network alterations and vulnerability to simulated neurodegeneration in breast cancer

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