Altered sleep patterns in patients with non-functional GHRH receptor

Oliveira, Francielle T; Salvatori, Roberto; Marcondes, José Antônio Miguel; Macena, Larissa Baracho; Oliveira-Santos, Alécia A; Faro, Augusto C N; Campos, Viviane C.; Oliveira, Carla R. P.; Costa, Úrsula; Aguiar‐Oliveira, Manuel H.

doi:10.1530/eje-17-0145

Cited by 11 publications

(3 citation statements)

References 50 publications

(22 reference statements)

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“…IGHD individuals exhibit normal quality of life ( 27 ), despite shorter and more fragmented sleep ( 53 ). The external and internal genitalia are essentially normal, which guarantees sexual life with a person of normal stature, with preserved reproductive capacity ( 20 , 24 , 25 , 54 ).…”

Section: Body Functions In Itabaianinha Syndromementioning

confidence: 99%

The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome

Aguiar‐Oliveira¹,

Salvatori²

2022

Archives of Endocrinology and Metabolism

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In the late 19 th century, José Dantas de Souza Leite, a physician born in Sergipe, published the first detailed clinical description of acromegaly under the guidance of the French neurologist Pierre Marie. In 2014, the Brazilian Society of Endocrinology and Metabolism created the "José Dantas de Souza Leite Award" , which is granted every two years to a Brazilian researcher who has contributed to the development of endocrinology. In 2022, the award was given to another physician from Sergipe, Manuel Hermínio de Aguiar Oliveira, from the Federal University of Sergipe for the description of "Itabaianinha syndrome" in a cohort of individuals with isolated GH deficiency due to a homozygous inactivating mutation in the GH-releasing hormone receptor gene. This research, which was carried out over almost 30 years, was performed in partnership with Roberto Salvatori from Johns Hopkins University and in collaboration with other researchers around the world. This review article tells the story of Souza Leite, some milestones in the history of GH, and summarizes the description of Itabaianinha syndrome.

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Section: Body Functions In Itabaianinha Syndromementioning

confidence: 99%

The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome

Aguiar‐Oliveira¹,

Salvatori²

2022

Archives of Endocrinology and Metabolism

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“…In addition, one subject who had GH replacement therapy earlier in her life, developed an ependymoma and appears to be tumor-free after surgical treatment. It was also shown that subjects with this syndrome have a reduction in sleep quality with no subjective consequences on the quality of life [ 67 ], deeper periodontal pockets with locally increased levels of several immune mediators [ 68 ], as well as higher prevalence of modest vestibular impairment and abnormal vestibular ocular reflex, likely related to the reported dizziness but without negative effects on postural balance or fall risk [ 69 ]. Furthermore, IGHD subjects had improved insulin sensitivity (ower homeostatic model assessment for insulin resistance [HOMA-IR], reduced creatine phosphokinase [CPK], higher C-reactive protein [CRP], lower sweating, normal vitamin D levels, and normal phosphorus: calcium homeostasis [ 70 ].…”

Section: Novel Findings In Individuals With Growth Hormone Deficiency or Growth Hormone Resistancementioning

confidence: 99%

Growth Hormone and Aging: New Findings

Bartke

Hascup

et al. 2021

World J Mens Health

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Complex relationships between growth hormone (GH) signaling and mammalian aging continue to attract attention of many investigators. Recent results include evidence that the impact of GH on genome maintenance (DNA damage and repair) is drastically different in normal as compared to cancer cells, consistent with GH promoting aging and cancer progression. Impact of GH on DNA methylation was studied as a possible mechanism linking actions of GH during early life to the trajectory of aging. Animals with reduced or enhanced GH signaling and novel animals with adipocyte-specific deletion of GH receptors were used to elucidate the effects of GH on white and brown adipose tissue, including the impact of this hormone on lipolysis, fibrosis, and thermogenesis. Effects of GH on adipose tissue related to lipid and energy metabolism emerge as mechanistic links between GH, healthspan, and lifespan. Treatment of healthy men with a combination of GH, dehydroepiandrosterone, and metformin was reported to restore thymus function and reduce epigenetic age. Studies of human subjects with deficiency of GH or GH receptors and studies of mice with the same endocrine syndromes identified several phenotypic changes related (positively or negatively) to the previously reported predisposition to healthy aging. Results of these and other recent studies advance present understanding of the mechanisms by which GH influences aging and longevity and of the trade-offs involved.

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“…Factors that affect thyroid function during pregnancy include iodine [ 3 ], human chorionic gonadotropin (hCG) concentration [ 4 ], the placenta [ 5 ], body mass index [ 6 ], and ethnicity [ 7 ]. As thyroid physiology changes during pregnancy due to these factors, each trimester should have its own TSH reference range based on the population of pregnant women.…”

mentioning

confidence: 99%

Wider reference ranges of serum thyroid stimulating hormone in pregnant Korean women: is it time to stop overtreatment?

Lim

2018

Korean J Intern Med

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Altered sleep patterns in patients with non-functional GHRH receptor

Abstract: Patients with IGHD due to GHRH resistance exhibit objective reduction in the sleep quality, with changes in NREM and REM sleep, with no detectable subjective consequences. GHRH resistance seems to have a preponderant role over GHD in the sleep quality of these subjects.

Cited by 11 publications

References 50 publications

The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome

The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome

Growth Hormone and Aging: New Findings

Wider reference ranges of serum thyroid stimulating hormone in pregnant Korean women: is it time to stop overtreatment?

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