Altered serum level of matrix metalloproteinase‐9 and its association with decision‐making in eating disorders

Matsumoto, Junko; Hirano, Yoshiyuki; Hashimoto, Kenji; Ishima, Tamaki; Kanahara, Nobuhisa; Niitsu, Tomihisa; Shiina, Akihiro; Hashimoto, Tasuku; Sato, Yasunori; Yokote, Koutaro; Murano, Shunichi; Kimura, Hiroshi; Hosoda, Yutaka; Shimizu, Eiji; Iyo, Masaomi; Nakazato, Michiko

doi:10.1111/pcn.12490

Cited by 11 publications

(5 citation statements)

References 49 publications

(89 reference statements)

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“…In patients with gambling disorder, BDNF has been recognized as a potential poor decision‐making indicator (Choi et al, 2016), negative correlation between serum level and IGT improvement scores has been shown. Similar results were obtained for other impulse‐control disorders like bulimia nervosa (Matsumoto et al, 2017). In chronic schizophrenia, BDNF serum level occurred to be negatively associated with mean IGT net score in last two trials, suggesting the relevance to impaired decision‐making (insufficient learning based on previous experiences) in the final part of IGT (Hori et al, 2014).…”

Section: Discussionsupporting

confidence: 85%

“…Similar results were obtained for other impulse-control disorders like bulimia nervosa (Matsumoto et al, 2017). In chronic schizophrenia, BDNF serum level occurred to be negatively associated with mean IGT net score in last two trials, suggesting the relevance to impaired decision-making (insufficient learning based on previous experiences) in the final part of IGT (Hori et al, 2014).…”

Section: Discussionsupporting

confidence: 78%

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Plasma biomarkers in adolescents with schizophrenia‐spectrum disorder

Zakowicz

Skibińska

Waśniewski

et al. 2023

Early Intervention Psych

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AimSchizophrenia onset in the developmental age has a strong neurodevelopmental burden and is associated with a poorer prognosis. The approach to diagnosis is still based on symptomatic description without objective validation. In this study, we aimed to compare the peripheral blood levels of hypothesized biomarker proteins: brain‐derived neurotrophic factor (BDNF), proBDNF, p75 neurotrophin receptor (p75NTR) and S100B between early‐onset schizophrenia‐spectrum adolescents (n = 45) and healthy controls (n = 34).MethodsClinical assessment of the participants encompassed symptomatic description with the use of structured interviews and executive function objective measurement. Plasma levels of BDNF protein were significantly lower in schizophrenia patients than in controls both at admission (p = .003) and 6–8 weeks follow‐up (p = .007).ResultsWe observed significant correlations between BDNF, proBDNF and p75NTR levels and positive and negative symptoms scale (PANSS) scores, p75NTR and S100B levels and suicidal parameters, as well as a correlation of BDNF plasma level with the risky decision‐making style in Iowa Gambling Task (IGT).ConclusionsThe results indicate a potential value of studied proteins as a biomarker in the diagnosis and monitoring of the disease's course.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 78%

Plasma biomarkers in adolescents with schizophrenia‐spectrum disorder

Zakowicz

Skibińska

Waśniewski

et al. 2023

Early Intervention Psych

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“…The median NOS score for included studies was 6.57 (IQR = 1, mean ± SD = 6.57 ± 0.75, range: 5–8) out of 9, which shows an estimated moderate to good quality. One study (7.14%) [ 43 ] had high risks of bias (scores 0–5), twelve studies (85.71%) [ 36 , 38 – 42 , 44 – 48 ] had moderate [ 34 , 39 ] risks of bias (scores 6–7), and one study (7.14%) [ 37 ] had low risks of bias (scores 8–9) in their methodological quality (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis

et al. 2022

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Background Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival, differentiation, development, and plasticity. Evidence suggests that fluctuations in peripheral levels (i.e., plasma or serum) of BDNF are associated with eating behaviors. Nevertheless, the findings are inconsistent. The purpose of this study is to determine if serum or plasma levels of BDNF are altered in individuals with eating disorders (EDs) compared to controls. Methods We conducted a systematic search of the core electronic medical databases from inception to March 2022 and identified observational studies that compared individuals with EDs to controls without EDs on serum or plasma levels of BDNF. R version 4.0.4 was used for all visualizations and calculations. Results The current meta-analysis comprised 15 studies that fulfilled the inclusion criteria. Subjects with EDs (n = 795) showed lower BDNF levels compared to non-EDs controls (n = 552) (SMD: − 0.49, 95% CI [− 0.89; − 0.08], p-value = 0.01). Moreover, subgroup analysis was conducted based on the specimen (plasma and serum), which revealed no statistically significant difference in the levels of BDNF between the two subgroups (p-value = 0.92). Additionally, meta-regression results revealed that publication year, mean age of the individuals with EDs, NOS scores, and the number of individuals with EDs collectively accounted for 25.99% percent of the existing heterogeneity. Conclusion Lower BDNF levels are associated with EDs.

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“…Furthermore, within the healthy control group, there was a positive correlation between MMP-2 (protein level), MMP-9 and TIMP-2 (mRNA levels) and performance in cognitive tasks: visuospatial performance, working memory tasks, auditory-verbal memory, the effectiveness of learning processes and verbal fluency [130]. Similar positive correlation between MMP-9 serum level and decision-making abilities was observed in bulimia nervosa patients [131]. Another report on MMP-9 involvement in cognition comes from a study on male bipolar patients.…”

Section: Synaptic Plasticity Learning and Memory: Mmps Expression Anmentioning

confidence: 86%

MMPs in learning and memory and neuropsychiatric disorders

Beroun¹,

Mitra²,

Michaluk³

et al. 2019

Cell. Mol. Life Sci.

160

127

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Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as well as cytokines and growth factors. By virtue of their expression and activity patterns in animal models and clinical investigations, as well as functional studies with gene knockouts and enzyme inhibitors, MMPs have been demonstrated to play a paramount role in many physiological and pathological processes in the brain. In particular, they have been shown to influence learning and memory processes, as well as major neuropsychiatric disorders such as schizophrenia, various kinds of addiction, epilepsy, fragile X syndrome, and depression. A possible link connecting all those conditions is either physiological or aberrant synaptic plasticity where some MMPs, e.g., MMP-9, have been demonstrated to contribute to the structural and functional reorganization of excitatory synapses that are located on dendritic spines. Another common theme linking the aforementioned pathological conditions is neuroinflammation and MMPs have also been shown to be important mediators of immune responses.

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Altered serum level of matrix metalloproteinase‐9 and its association with decision‐making in eating disorders

Abstract: These results suggest that the serum level of MMP-9 plays a role in the pathophysiology of AN, and both the serum levels of mBDNF and MMP-9 may be associated with decision-making abilities in patients with BN.

Cited by 11 publications

References 49 publications

Plasma biomarkers in adolescents with schizophrenia‐spectrum disorder

Plasma biomarkers in adolescents with schizophrenia‐spectrum disorder

Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis

MMPs in learning and memory and neuropsychiatric disorders

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