Altered serum glyceraldehyde-derived advanced glycation end product (AGE) and soluble AGE receptor levels indicate carbonyl stress in patients with schizophrenia

Takeda, Mayu; Ohnuma, Tohru; Takeuchi, Masayoshi; Katsuta, Narimasa; Maeshima, Hitoshi; Takebayashi, Yuto; Higa, Motoyuki; Nakamura, Tôru; Nishimon, Shohei; Sannohe, Takahiro; Hotta, Yuri; Hanzawa, Ryo; Higashiyama, Ryoko; Shibata, Nobuto; Gohda, Tomohito; Suzuki, Yusuke; Yamagishi, Sho‐ichi; Tomino, Yasuhiko; Arai, Heii

doi:10.1016/j.neulet.2015.03.002

Cited by 22 publications

(35 citation statements)

References 30 publications

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“…Psychotic patients in general are in a significantly increased longterm con dition of oxidative stress [102,103] . Oxidative stress markers, such as pentosidine [104] , glycer-AGE [105] and thiobarbituric acid reactive substances [103,106] were found to be higher among people with Sz and carbonyl stress was found to be lower in people with the disorder [104,105,107] . However, those oxidative markers have overlapping levels between people with Sz and healthy individuals, suggesting the discriminability of those markers is low [102] .…”

Section: Metabolismmentioning

confidence: 90%

Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics

Lai

Scarr

Udawela

et al. 2016

WJP

137

108

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Identifying biomarkers that can be used as diagnostics or predictors of treatment response (theranostics) in people with schizophrenia (Sz) will be an important step towards being able to provide personalized treatment. Findings from the studies in brain tissue have not yet been translated into biomarkers that are practical in clinical use because brain biopsies are not acceptable and neuroimaging techniques are expensive and the results are inconclusive. Thus, in recent years, there has been search for blood-based biomarkers for Sz as a valid alternative. Although there are some encouraging preliminary data to support the notion of peripheral biomarkers for Sz, it must be acknowledged that Sz is a complex and heterogeneous disorder which needs to be further dissected into subtype using biological based and clinical markers. The scope of this review is to critically examine published blood-based biomarker of Sz, focusing on possible uses for diagnosis, treatment response, or their relationship with schizophreniaassociated phenotype. We sorted the studies into six categories which include: (1) brain-derived neurotrophic factor; (2) inflammation and immune function; (3) neurochemistry; (4) oxidative stress response and metabolism; (5) epigenetics and microRNA; and (6) transcriptome and proteome studies. This review also summarized the molecules which have been conclusively reported as potential blood-based biomarkers for Sz in different blood cell types. Finally, we further discusses the pitfall of current blood-based studies and suggest that a prediction model-based, Sz specific, blood World Journal of Psychiatry W J P oriented study design as well as standardize blood collection conditions would be useful for Sz biomarker development.

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Section: Metabolismmentioning

confidence: 90%

Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics

Lai

Scarr

Udawela

et al. 2016

WJP

137

108

View full text Add to dashboard Cite

show abstract

“…Converging evidence indicates that the OS plays a role in SCZ pathophysiology [46][47][48][49]. A study on the disturbances in antioxidative defense systems indicated an increase in free radical generation and antioxidant defense impairment in SCZ patients [46].…”

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

“…Accumulation of these products is called carbonyl stress, and has been suggested as an environmental factor in the pathophysiology of SCZ [47,49,53]. AGEs interact with AGE receptors (RAGE) on the cell membrane, which induces deleterious effects by increasing oxidative and carbonyl stress [49,54].…”

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

“…AGEs interact with AGE receptors (RAGE) on the cell membrane, which induces deleterious effects by increasing oxidative and carbonyl stress [49,54]. A recent cross-sectional and longitudinal study showed altered carbonyl stress markers levels in SCZ [49]. Significantly increased glyceraldehyde-derived AGEs (Glycer-AGEs) levels and decreased soluble form of the RAGE (sRAGE) levels were found in acute SCZ [49].…”

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

“…A recent cross-sectional and longitudinal study showed altered carbonyl stress markers levels in SCZ [49]. Significantly increased glyceraldehyde-derived AGEs (Glycer-AGEs) levels and decreased soluble form of the RAGE (sRAGE) levels were found in acute SCZ [49]. Although controversial in humans, a counter-regulatory mechanism that abolishes the AGEs-RAGE axis effects was associated with sRAGE [55].…”

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

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Biomarkers and schizophrenia: a qualitative review

Silva¹,

Pinto²

2017

IJCNMH

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Schizophrenia (SCZ) is a psychiatric disorder with a broad spectrum of biological and clinical manifestations of yet not completely clear pathophysiological mechanisms. Several lines of evidence have been supporting the idea that immunoinflammatory, oxidative, hormonal and cellular dysfunctions are implicated on the biomolecular basis of SCZ. However, accurate diagnosis and selection of appropriate treatments remains challenging as a result of the scarcity of objective tests. Furthermore, there is a compelling need to find biomarkers that could predict drug response and tailor pharmacological treatment, particularly in drug-naïve first episode psychosis (FEP). Hence, numerous technologies have been employed in order to search for SCZ biological markers, but evidence relating them to treatment efficacy is lacking. In this regard, some preliminary data suggest promising results. The current review provides information on: (1) potential biomarkers associated with biological disturbances and (2) biological markers associated with treatment response.

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Associations of common copy number variants in glutathione S‐transferase mu 1 and D‐dopachrome tautomerase‐like protein genes with risk of schizophrenia in a Japanese population

Nakamura

Ohnuma

Hanzawa

et al. 2015

American J of Med Genetics Pt B

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Oxidative-stress, genetic regions of interest (1p13 and 22q11), and common copy number variations (CNVs) may play roles in the pathophysiology of schizophrenia. In the present study, we confirmed associations between schizophrenia and the common CNVs in the glutathione (GSH)-related genes GSTT1, DDTL, and GSTM1 using quantitative real-time polymerase chain reaction analyses of 620 patients with schizophrenia and in 622 controls. No significant differences in GSTT1 copy number distributions were found between patient groups. However, frequencies of characterized CNVs and assumed gain alleles of DDTL and GSTM1 were significantly higher in patients with schizophrenia. In agreement with a previous report, the present data indicate that gains in the CNV alleles DDTL and GSTM1 are genetic risk factors in Japanese patients with schizophrenia, and suggest involvement of micro-inflammation and oxidative stress in the pathophysiology of schizophrenia.

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Altered serum glyceraldehyde-derived advanced glycation end product (AGE) and soluble AGE receptor levels indicate carbonyl stress in patients with schizophrenia

Cited by 22 publications

References 30 publications

Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics

Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics

Biomarkers and schizophrenia: a qualitative review

Associations of common copy number variants in glutathione S‐transferase mu 1 and D‐dopachrome tautomerase‐like protein genes with risk of schizophrenia in a Japanese population

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