Altered sensory nerve excitability in fibromyalgia

Teng, Hao Wen; Tani, Jowy; Chang, Tsui San; Chen, Hung‐Ju; Lin, Yi; Lin, Cindy; Sung, Jia Ying

doi:10.1016/j.jfma.2021.02.003

Cited by 7 publications

(8 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The physiopathology of the FM syndrome described in the literature is compatible with a central state of hyperexcitability of the nociceptive system [ 20 , 21 ], specifically, a persistent over-activation of Theta and Beta bands [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Fibromyalgia Detection Based on EEG Connectivity Patterns

Martín-Brufau

Gómez

Sánchez-Sánchez-Rojas

et al. 2021

JCM

View full text Add to dashboard Cite

Objective: The identification of a complementary test to confirm the diagnosis of FM. The diagnosis of fibromyalgia (FM) is based on clinical features, but there is still no consensus, so patients and clinicians might benefit from such a test. Recent findings showed that pain lies in neuronal bases (pain matrices) and, in the long term, chronic pain modifies the activity and dynamics of brain structures. Our hypothesis is that patients with FM present lower levels of brain activity and therefore less connectivity than controls. Methods: We registered the resting state EEG of 23 patients with FM and compared them with 23 control subjects’ resting state recordings from the PhysioBank database. We measured frequency, amplitude, and functional connectivity, and conducted source localization (sLORETA). ROC analysis was performed on the resulting data. Results: We found significant differences in brain bioelectrical activity at rest in all analyzed bands between patients and controls, except for Delta. Subsequent source analysis provided connectivity values that depicted a distinct profile, with high discriminative capacity (between 91.3–100%) between the two groups. Conclusions: Patients with FM show a distinct neurophysiological pattern that fits with the clinical features of the disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Fibromyalgia Detection Based on EEG Connectivity Patterns

Martín-Brufau

Gómez

Sánchez-Sánchez-Rojas

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…As the K + channels are distributed over the nociceptive neuronal membrane, reduced K + channel transmission can cause over-sensitivity to pain. 13 It has been suggested that the reduced K + channels function in the nociceptive pathway could be responsible for several types of pain (23). Ishikawa et al (24) reported that changes occurred in the expression of the Kv channels in the dorsal root ganglia after axotomy.…”

Section: Results Of Protein-protein Interaction Analysismentioning

confidence: 99%

“…The majority of previous studies that have investigated the relationship between pain and ion channels have focussed on depolarising ion channels, and few studies have examined K+ channels, which have significant roles in control and axonal stimulation (13). Some previous clinical studies have proposed that impaired K + channel activity is one of the mechanisms responsible for hyperalgesia and allodynia, (14,15) while other studies have claimed that the use of K + channel activators could be promising in the treatment of neuropathic and chronic pain in the future (16,17).…”

Section: Introductionmentioning

confidence: 99%

Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome

Taş

Hayta

Karadağ

et al. 2022

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Although there is not yet full clarity of the pathogenesis of fibromyalgia syndrome (FM), central sensitization is considered to be responsible. The purpose of this study was to measure the plasma levels of potassium ion channel proteins (human KCNH2, KCNH6 and KCNH7) in FM patients and healthy control subjects. The study sample includes 76 newly diagnosed FM patients and 79 healthy individuals. Venous blood samples were taken to measure the plasma levels of KCNH2, KCNH6 and KCNH7. Pain severity in FM patients was assessed using a visual analog scale (VAS). Bioinformatics analysis was performed using the STRING v 11 Protein interaction tool. Age, gender and body mass index were seen to be similar in both groups. In comparisons between FM and control groups, KCNH2 plasma levels was found to be significantly lower in the FM group. No significant correlation was found between plasma levels of KCNH2, KCNH6 and KCNH7 protein levels and VAS score of patients with FM. The KCNH2 protein had a high homology score with 9 proteins. The plasma levels of KCNH2 FM patients were found to be lower than those of the healthy control subjects, no difference was determined in respect of the plasma levels of KCNH6 and KCNH7. These results may be of use in guiding future studies on the pathogenesis of FM.

show abstract

“…The nerve excitability test uses threshold tracking techniques to study axon excitability and neuronal plasticity in vivo by indirectly examining ion channels and the resting membrane potential [3,4]. Automated protocols for assessing nerve excitability have been used in numerous studies, investigating the pathophysiology of diseases affecting central to peripheral nerve systems, such as spinal cord injury, cerebellar disorders, amyotrophic lateral sclerosis, radiculopathy, fibromyalgia, and metabolic, toxic, and demyelinating neuropathies [5][6][7][8][9][10][11][12]. Excitability properties of the median nerve have been studied in people with ischemic and hemorrhagic stroke.…”

Section: Introductionmentioning

confidence: 99%

Neuroplasticity of peripheral axonal properties after ischemic stroke

et al. 2022

Self Cite

View full text Add to dashboard Cite

Objective This study investigated how peripheral axonal excitability changes in ischemic stroke patients with hemiparesis or hemiplegia, reflecting the plasticity of motor axons due to corticospinal tract alterations along the poststroke stage. Methods Each subject received a clinical evaluation, nerve conduction study, and nerve excitability test. Nerve excitability tests were performed on motor median nerves in paretic and non-paretic limbs in the acute stage of stroke. Control nerve excitability test data were obtained from age-matched control subjects. Some patients underwent excitability examinations several times in subacute or chronic stages. Results A total of thirty patients with acute ischemic stroke were enrolled. Eight patients were excluded due to severe entrapment neuropathy in the median nerve. The threshold current for 50% compound muscle action potential (CMAP) was higher in paretic limbs than in control subjects. Furthermore, in the cohort with severe patients (muscle power ≤ 3/5 in affected hands), increased threshold current for 50% CMAP and reduced subexcitability were noted in affected limbs than in unaffected limbs. In addition, in the subsequent study of those severe patients, threshold electrotonus increased in the hyperpolarization direction: TEh (100–109 ms), and the minimum I/V slope decreased. The above findings suggest the less excitable and less accommodation in lower motor axons in the paretic limb caused by ischemic stroke. Conclusion Upper motor neuron injury after stroke can alter nerve excitability in lower motor neurons, and the changes are more obvious in severely paretic limbs. The accommodative changes of axons progress from the subacute to the chronic stage after stroke. Further investigation is necessary to explore the downstream effects of an upper motor neuron insult in the peripheral nerve system.

show abstract

Altered sensory nerve excitability in fibromyalgia

Cited by 7 publications

References 40 publications

Fibromyalgia Detection Based on EEG Connectivity Patterns

Fibromyalgia Detection Based on EEG Connectivity Patterns

Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome

Neuroplasticity of peripheral axonal properties after ischemic stroke

Contact Info

Product

Resources

About