Altered sarcoplasmic reticulum function after high-intensity exercise

Byrd, S. K.; McCutcheon, L. J.; Hodgson, David; Gollnick, P. D.

doi:10.1152/jappl.1989.67.5.2072

Cited by 108 publications

(75 citation statements)

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“…Increase in ionized calcium, parallel to the drop in pH in both subject groups, reflects increased calcium release from albumin and depression of calcium reuptake by sarcoplasmic reticulum (6). In addition, a similar HR-systolic blood pressure product suggests that the load to the heart was comparable during maximal exercise.…”

Section: Discussionmentioning

confidence: 88%

Effect of fitness on arm vascular and metabolic responses to upper body exercise

Volianitis

Yoshiga

Nissen

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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-We investigated arm perfusion and metabolism during upper body exercise. Eight average, fit subjects and seven rowers, mean Ϯ SE maximal oxygen uptake (V O2 max) 157 Ϯ 7 and 223 Ϯ 14 ml O2⅐ kg Ϫ0.73 ⅐min Ϫ1 , respectively, performed incremental arm cranking to exhaustion. Arm blood flow (ABF) was measured with thermodilution and arm muscle mass was estimated by dual-energy X-ray absorptiometry. During maximal arm cranking, pulmonary V O2 was ϳ45% higher in the rowers compared with the untrained subjects and peak ABF was 6.44 Ϯ 0.40 and 4.55 Ϯ 0.26 l/min, respectively (P Ͻ 0.05). The arm muscle mass for the rowers and the untrained subjects was 3.5 Ϯ 0.4 and 3.3 Ϯ 0.1 kg, i.e., arm perfusion was 1.9 Ϯ 0.2 and 1.4 Ϯ 0.1 l blood⅐kg Ϫ1 ⅐min Ϫ1 , respectively (P Ͻ 0.05). The arteriovenous O2 difference was 156 Ϯ 7 and 120 Ϯ 8 ml/l, respectively, and arm V O2 was 0.98 Ϯ 0.08 and 0.60 Ϯ 0.04 l/min corresponding with 281 Ϯ 22 and 181 Ϯ 12 ml/kg, while arm O2 diffusional conductance was 49.9 Ϯ 4.3 and 18.6 Ϯ 3.2 ml⅐min Ϫ1 ⅐mmHg Ϫ1 , respectively (P Ͻ 0.05). Also, lactate release in the rowers was almost three times higher than in the untrained subjects (26.4 Ϯ 1.1 vs. 9.5 Ϯ 0.4 mmol/min, P Ͻ 0.05). The energy requirement of an ϳ50% larger arm work capacity after long-term arm endurance training is covered by an ϳ60% increase in aerobic metabolism and an almost tripling of the anaerobic capacity. arm exercise; blood pressure; lactate; oxygen diffusion; oxygen uptake CHRONIC ENDURANCE EXERCISE induces central and peripheral changes that enhance cardiac output and maximal oxygen uptake (V O 2 max ) (9). The important contribution of peripheral circulatory changes to this adaptive response is demonstrated by the hyperbolic relationship between V O 2 max and total vascular resistance both in cross-sectional and longitudinal studies (8). Because during maximal exercise ϳ85% of cardiac output is directed to the working skeletal muscles, it would be expected that the ϳ50% greater cardiac output after endurance training would result in an increase in muscle blood flow. Yet, although animal data support this assumption (19), it has been difficult to demonstrate a similar increase in muscle blood flow in trained humans (8). One explanation may be that a traininginduced increase in muscle mass makes an estimate of blood flow per unit of muscle relatively stable. Another consideration is that leg muscle blood flow has been evaluated after relatively short training periods (18, 23).In contrast to the legs, only specifically arm-trained subjects use their arms intensively. Thus arm cranking elicits a lower V O 2 max than leg exercise with a typical ratio between the two values of ϳ0.7 (26). Conversely, in arm-trained subjects, including rowers, V O 2 max during arm cranking reaches similar or even higher values than those obtained with their trained legs. During arm cranking at ϳ80% of V O 2 max , an arm blood flow (ABF) of ϳ2.4 l/min is reported in the untrained subjects (1) and ϳ3.8 l/min in arm-trained subjects (16), suggesting tha...

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Section: Discussionmentioning

confidence: 88%

Effect of fitness on arm vascular and metabolic responses to upper body exercise

Volianitis

Yoshiga

Nissen

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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show abstract

“…It has also been postulated that low muscle pH and high muscle temperatures may be associated with impaired sarcoplasmic reticulum function (McCutcheon et al 1991). While moderate increases in muscle temperature are probably favourable for metabolic processes, very high temperatures may be a contributory factor in fatigue, for example by altering calcium uptake by the sarcoplasmic reticulum (Byrd et al 1989). While postexercise plasma [lactate] increased with training, there was no increase in muscle [lactate].…”

Section: Discussionmentioning

confidence: 99%

Effects of prolonged training, overtraining and detraining on skeletal muscle metabolites and enzymes

McGowan

Golland

Evans

et al. 2002

Equine Veterinary Journal

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“…or fatiguing exercise generates a 20-50% transient decrease in Ca 2+ uptake and release, returning to basal levels following 60 min recovery (Byrd et al 1989;Matsunaga et al 2002). ] .…”

Section: Calciummentioning

confidence: 99%