Altered Rich-Club Organization and Regional Topology Are Associated With Cognitive Decline in Patients With Frontal and Temporal Gliomas

Liu, Yong; Yang, Kun; Hu, Xinhua; Xiao, Chaoyong; Rao, Jiang; Li, Zonghong; Liu, Dongming; Zou, Yuanjie; Chen, Jiu; Liu, Hongyi

doi:10.3389/fnhum.2020.00023

Cited by 26 publications

(15 citation statements)

References 64 publications

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“…The second set of scan parameters were used to obtain MRI data for all of the CN subjects. We used a gradient-recalled echoplanar imaging sequence, including 140/240 volumes (for the first set of parameters between 2013 and 2016/the second set of parameters between 2017 and 2019, respectively) (33,34), with repetition times (TR) = 2,000 ms/2,000 ms, echo times (TE) = Different parameters were used by our research team to optimize and improve the imaging protocol and were not related to the purposes of the study. Even if the parameters were homogeneous in the same scanner, parameter differences were taken into consideration in the GLM as a covariable of non-interest.…”

Section: Mri Data Acquisitionmentioning

confidence: 99%

Structural and Functional Reorganization Within Cognitive Control Network Associated With Protection of Executive Function in Patients With Unilateral Frontal Gliomas

Liu

et al. 2020

Front. Oncol.

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Background: The cognitive control network (CCN) is widely considered to be a frontoparietal circuit that is involved in executive function. This study aimed to investigate the structural and functional plasticity within the CCN in unilateral frontal gliomas, which are associated with the protection of executive functions.Methods: To detect structural and functional changes within the CCN, we measured gray matter (GM) volume, regional homogeneity, the amplitude of low-frequency fluctuation (ALFF), degree centrality, and functional connectivity within the CCN in 37 patients with gliomas invading the left frontal lobe (n = 16) or the right frontal lobe (n = 21) and 40 healthy controls (CNs). Partial correlation analysis was performed to assess the association between the altered structural and functional indices and executive function.Results: When the tumor invaded the left frontal lobe, the patients showed reduced ALFF in the dorsal medial prefrontal cortex (dmPFC) within the CCN and increased ALFF in the right superior parietal cortex (rSP) within the CCN compared to the CNs. When the tumor invaded the right frontal lobe, the patients showed significantly increased GM volume and ALFF in the left superior parietal cortex (lSP) within the CCN compared to the CNs. Furthermore, the patients showed significantly increased functional connectivities between the lSP and the dmPFC and between the lSP and the rSP within the CCN compared to the CNs. Increased ALFF in the lSP within the CCN was positively correlated with executive function.Conclusions: Tumors invading the frontal lobe induced contralesional structural and functional reorganization within the posterior CCN in patients with unilateral frontal gliomas. This further suggests that the contralesional superior parietal cortex acts as a functional compensation hub within the CCN, which may protect it against the detrimental effects of tumor invasion on executive functions.

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Section: Mri Data Acquisitionmentioning

confidence: 99%

Structural and Functional Reorganization Within Cognitive Control Network Associated With Protection of Executive Function in Patients With Unilateral Frontal Gliomas

Liu

et al. 2020

Front. Oncol.

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“…Detailed inclusion and exclusion criteria are provided in our previously published studies ( Hu et al, 2020 ; Liu et al, 2020a , c ) and in Supplementary Methods 1 .…”

Section: Methodsmentioning

confidence: 99%

Stable functional compensation within hippocampal-subregion networks in patients with temporal glioma before and after surgery

Zhang

Liu

et al. 2022

Front. Neurosci.

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ObjectiveTo identify whether tumor invasion of the temporal lobe induces functional compensation of the hippocampal-subregion (HIPsub) network connectivity before surgery, and to further validate the stability of this functional compensation within the HIPsub network in patients with temporal glioma tumor (TTumor) after surgical resection of the tumor.MethodsIn the first cohort, analysis of HIPsub functional connectivity (FC) was conducted to identify the functional compensation of the altered HIPsub connectivity pattern in TTumor through a pattern classification approach. Then, the second cohort investigated whether functional compensation in TTumor patients changed after surgical resection of the tumor.ResultsIn the first cohort, this study identified altered HIPsub network connectivity patterns and its functional compensation regions (i.e., left parahippocampal gyrus and bilateral cerebellum anterior lobe) in TTumor patients. Second, the altered HIPsub network connectivity patterns had the power to discriminate TTumor patients from healthy controls (CN) on an individual subject basis, with an AUC of 97.0%, sensitivity of 93.5%, and specificity of 90.3%. Finally, in the second cohort, we found that functional connectivities of functional compensation regions within the HIPsub network in TTumor patients did not change between before and after surgery.ConclusionThis study provides novel evidence regarding functional compensation within the HIPsub network in TTumor patients. It has been suggested that the fine hippocampal subregion was more sensitive, which reveals functional compensation induced by tumor invasion of the temporal lobe. Furthermore, this study verified the stability and persistence of this functional compensation in TTumor patients after surgical resection of the tumor.

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“…Rich club analysis might be helpful in understanding stroke pathophysiology, underlying diagnosis biomarker, and functional recovery ( Lim and Kang, 2015 ). Rich club analysis has been extensively applied to cognitive impairment caused by Alzheimer’s disease (AD) ( Daianu et al, 2015 ; Yan et al, 2018 ), cerebral small vessel disease ( van Leijsen et al, 2019 ), and frontal and temporal gliomas ( Liu et al, 2020 ). However, a few studies of rich club analysis on PSCI patients had been conducted.…”

Section: Introductionmentioning

confidence: 99%

Decreased Functional Connectivities of Low-Degree Level Rich Club Organization and Caudate in Post-stroke Cognitive Impairment Based on Resting-State fMRI and Radiomics Features

et al. 2022

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BackgroundStroke is an important cause of cognitive impairment. Rich club organization, a highly interconnected network brain core region, is closely related to cognition. We hypothesized that the disturbance of rich club organization exists in patients with post-stroke cognitive impairment (PSCI).MethodsWe collected data on resting-state functional magnetic resonance imaging (rs-fMRI) with 21 healthy controls (HC), 16 hemorrhagic stroke (hPSCI), and 21 infarct stroke (iPSCI). 3D shape features and first-order statistics of stroke lesions were extracted using 3D slicer software. Additionally, we assessed cognitive function using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE).ResultsNormalized rich club coefficients were higher in hPSCI and iPSCI than HC at low-degree k-levels (k = 1–8 in iPSCI, k = 2–8 in hPSCI). Feeder and local connections were significantly decreased in PSCI patients versus HC, mainly distributed in salience network (SN), default-mode network (DMN), cerebellum network (CN), and orbitofrontal cortex (ORB), especially involving the right and left caudate with changed nodal efficiency. The feeder and local connections of significantly between-group difference were positively related to MMSE and MoCA scores, primarily distributed in the sensorimotor network (SMN) and visual network (VN) in hPSCI, SN, and DMN in iPSCI. Additionally, decreased local connections and low-degree ϕnorm(k) were correlated to 3D shape features and first-order statistics of stroke lesions.ConclusionThis study reveals the disrupted low-degree level rich club organization and relatively preserved functional core network in PSCI patients. Decreased feeder and local connections in cognition-related networks (DMN, SN, CN, and ORB), particularly involving the caudate nucleus, may offer insight into pathological mechanism of PSCI patients. The shape and signal features of stroke lesions may provide an essential clue for the damage of functional connectivity and the whole brain networks.

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Altered Rich-Club Organization and Regional Topology Are Associated With Cognitive Decline in Patients With Frontal and Temporal Gliomas

Cited by 26 publications

References 64 publications

Structural and Functional Reorganization Within Cognitive Control Network Associated With Protection of Executive Function in Patients With Unilateral Frontal Gliomas

Structural and Functional Reorganization Within Cognitive Control Network Associated With Protection of Executive Function in Patients With Unilateral Frontal Gliomas

Stable functional compensation within hippocampal-subregion networks in patients with temporal glioma before and after surgery

Decreased Functional Connectivities of Low-Degree Level Rich Club Organization and Caudate in Post-stroke Cognitive Impairment Based on Resting-State fMRI and Radiomics Features

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