Altered Retinal Nerve Fiber Layer Thickness and Choroid Thickness in Patients with Migraine

Ao, Ran; Wang, Rongfei; Yang, Mo; Wei, Shimin; Shi, Xi; Yu, Shengyuan

doi:10.1159/000494671

Cited by 22 publications

(14 citation statements)

References 41 publications

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“…OC lined with olfactory epithelium is located in the upper part of the nasal cavity between the medial turbinate and nasal septum. Smell recognition initiates with the activation of G-protein cascades in the bipolar olfactory neurons of OC contacting odor molecules [ 45 , 46 ]. Both the study of Altundag et al comparing OD cases due to COVID-19 or other URIs with healthy controls and the study of Tekcan Sanli et al comparing COVID-19 cases with OD and COVID-19 cases without OD revealed that patients with OD had significantly higher values for mean right and mean left OC widths and total bilateral OC volume which interestingly had inverse correlations with TDI scores of sniffin’ sticks test [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

Olfactory system measurements in COVID-19: a systematic review and meta-analysis

et al. 2022

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Purpose The neurotropism of SARS-CoV-2 and the consequential damage to the olfactory system have been proposed as one of the possible underlying causes of olfactory dysfunction in COVID-19. We aimed to aggregate the results of the studies which reported imaging of the olfactory system of patients with COVID-19 versus controls. Methods PubMed and EMBASE were searched to identify relevant literature reporting the structural imaging characteristics of the olfactory bulb (OB), olfactory cleft, olfactory sulcus (OS), or olfactory tract in COVID-19 patients. Hedge’s g and weighted mean difference were used as a measure of effect size. Quality assessment, subgroup analyses, meta-regression, and sensitivity analysis were also conducted. Results Ten studies were included in the qualitative synthesis, out of which seven studies with 183 cases with COVID-19 and 308 controls without COVID-19 were enrolled in the quantitative synthesis. No significant differences were detected in analyses of right OB volume and left OB volume. Likewise, right OS depth and left OS depth were also not significantly different in COVID-19 cases compared to non-COVID-19 controls. Also, we performed subgroup analysis, meta-regression, and sensitivity analysis to investigate the potential effect of confounding moderators. Conclusion The findings of this review did not confirm alterations in structural imaging of the olfactory system, including OB volume and OS depth by Covid-19 which is consistent with the results of recent histopathological evaluations. Supplementary Information The online version contains supplementary material available at 10.1007/s00234-022-03014-8.

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Section: Discussionmentioning

confidence: 99%

Olfactory system measurements in COVID-19: a systematic review and meta-analysis

et al. 2022

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“…Reggio et al [21] reported significant thinning in RNFL, GCC, and choroidal in migraine patients compared with the healthy controls. Ao et al [22] found that the nasal peripapillary RNFL and inferior inner macular layer were significantly thinner in the migraine group with aura, but there was no difference between the two migraine groups and the control group. In contrast, there are also studies reporting no differences between the migraine patients and control cases Figure 1: e quantitative analysis of vascular densities (VDs) performed using the colored VD maps of the macula (ETDRS chart) and macular OCT-A scans.…”

Section: Discussionmentioning

confidence: 98%

Altered Macular Vasculature in Migraine Patients without Aura: Is It Associated with Ocular Vasculature and White Matter Hyperintensities?

Taşlı

Ersoy

2020

Journal of Ophthalmology

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Aim. We aimed to determine the alterations in macular and optic nerve vasculature in patients with migraine without aura using optical coherence tomography-angiography (OCTA). We also aimed to determine whether there were clinical differences and alterations in ocular structures in migraine cases with white matter hyperintensities (WMH) using magnetic resonance imaging (MRI). Materials and Methods. The study group comprised patients with migraine without aura and age- and sex-matched healthy controls. Detailed histories of the patients with migraine were recorded including the disease duration, number of attacks in the last month, and attack durations. Visual evoked potentials (VEP) were recorded in all migraine patients. The migraine disability assessment (MIDAS) questionnaire was administered to all patients. The patients were divided into two groups as migraine with WMHs and migraine without WMHs. All subjects underwent a complete neurological and ophthalmological examination. Only the right eyes of the patients were included in the study. Retinal imaging was performed using OCT and OCTA. Results. A total of 66 migraine patients (29 with WMH and 37 without WMH) and 43 healthy controls were included in this study. Among the migraine patients, disease duration, attack frequency in the last month, attack durations, and the visual analogue scale (VAS), MIDAS, and VEP scores were all similar between those with and without WMHs. There was no significant difference between the groups regarding the ganglion cell complex, foveal, and retinal nerve fiber layer thicknesses. The superficial or deep vascular perfusion densities of the optic disc were also similar between the groups. The foveal avascular zone (FAZ) was significantly larger (P=0.034), and both superficial and deep macular vascular densities were significantly lower in the migraine groups compared with the healthy controls (P=0.001). There was no significant difference concerning the FAZ size or vascular densities between the migraine groups with and without WMHs. In the correlation analysis performed between the migraine patients, the FAZ size was correlated with age and VAS and MIDAS scores while both superficial and deep macular vascular densities were negatively correlated with age and VAS and MIDAS scores. Conclusion. We suggest that for not only migraine with aura but also migraine without aura, neurovascular structures play an important role in pathogenesis, and novel studies are warranted to elucidate the alterations in these and determine the significance of WMHs in these patient groups.

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“…Other studies demonstrated that the nasal peripapillary RNFL (pRNFL) diameter of positive aura patients was less than control group, as thinner nasal pRNFL quadrant was more prone to neurodegeneration [23,24].…”

Section: Discussionmentioning

confidence: 99%

The potential impact of migraine headache on retinal nerve fiber layer thickness

Mohamed

Hussein

Thabet

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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Background Migraine is a common, chronic, multifactorial neurovascular disorder. It may result in hypoperfusion of other areas other than the brain, as the eye. It may lead to change of the retinal nerve fiber layers (RNFL) thickness and axonal loss even up to severe damage of the eye structures, including the retina with frequent headache attacks. This study aimed to quantify the thickness of RNFL which gives a good idea about the condition of axons and loss of ganglion cells in migraine patients. Also, to detect if there is any correlation between these measurements and clinical characteristics of migraine. Results The RNFL thickness was significantly thinner in patients with migraine compared to healthy controls in all quadrants of retina in both sides (p value < 0.05). However, there was no significant difference in RNFL thickness in migraine patients with aura compared to patients without aura in all retinal quadrants in both sides (p value > 0.05). The headache intensity was negatively correlated with RNFL thickness in the inferior (r = − 0.342, P = 0.031) and nasal (r = − 0.349, P = 0.027) quadrants on LT side, also there was a significant positive correlation between RNFL thickness and both of nausea and tolerability in the RT superior quadrant (r = 0.467, P = 0.002); (r = 0.322, P = 0.043), respectively, but there was no significant correlation found between the RNFL thickness and disability, attacks duration, disease duration and frequency in all retinal quadrants on both sides (P > 0.05). Conclusion The main conclusion of our work was that RNFL thickness was significantly affected in migraine patients in comparison to healthy controls, but there were no significant impact of the migraine characteristics including aura, severity, frequency, or duration of headache attacks on RNFL thickness.

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Altered Retinal Nerve Fiber Layer Thickness and Choroid Thickness in Patients with Migraine

Cited by 22 publications

References 41 publications

Olfactory system measurements in COVID-19: a systematic review and meta-analysis

Olfactory system measurements in COVID-19: a systematic review and meta-analysis

Altered Macular Vasculature in Migraine Patients without Aura: Is It Associated with Ocular Vasculature and White Matter Hyperintensities?

The potential impact of migraine headache on retinal nerve fiber layer thickness

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