Altered resting state functional connectivity of fear and reward circuitry in comorbid PTSD and major depression

Lee, Seonjoo; Helpman, Liat; Papini, Santiago; Schneier, Franklin R.; Markowitz, John C.; Meter, Page E. Van; Lindquist, Martin A.; Wager, Tor D.; Neria, Yuval

doi:10.1002/da.22594

Cited by 74 publications

(55 citation statements)

References 61 publications

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“…However, we did not include depression scores as another covariate as ANCOVA should be avoided when groups are not formed by random assignment (Miller and Chapman, 2001), as was the case in the presented study. Still, as differences between PTSD patients with and without major depressive disorder in rs-FC have been previously reported (Zhu et al, 2016), future studies should attempt to replicate the present finding while including a depression non-PTSD group to enhance the specificity of current results. Finally, our PTSD group ranged in age from 22 to 54 years, which might have limited our ability to find possible moderation effects of group on the relationship between age and rs-FC.…”

Section: Discussionsupporting

confidence: 61%

“…FMRI data were preprocessed using MATLAB version R2016a (The MathWorks, Inc., Natick, MA, USA) and statistical parametric mapping software (SPM12; Wellcome Trust Centre for Neuroimaging, UCL, London, UK), as previously done in our laboratory (Zhu et al, 2016). All functional images were slice time and motion corrected, co-registered to each participant’s T1-weighted structural image and normalized to Montreal Neurological Institute (MNI) canonical template and smoothed with an 8 mm full-width-at-half-maximum (FWHM) Gaussian kernel.…”

Section: Methodsmentioning

confidence: 99%

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Resting-state functional connectivity of anterior and posterior hippocampus in posttraumatic stress disorder

Lazarov

Lee

Suarez‐Jimenez

et al. 2017

Journal of Psychiatric Research

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Posttraumatic stress disorder (PTSD) has been associated with altered resting-state functional connectivity (rs-FC) of several brain regions within the salience (SN) and default-mode (DMN) networks, including the hippocampus. However, most rs-FC studies have not focused primarily on the hippocampus, nor have they appreciated its structural heterogeneity, despite clear evidence for a dissociation between posterior and anterior hippocampal connectivity. Here, we examine rs-FC of anterior and posterior hippocampus with key regions in the SN (amygdala, insula, and dorsal anterior cingulate cortex/pre-supplementary motor area) and DMN (ventromedial prefrontal cortex, posterior cingulate cortex, and precuneus) previously implicated in PTSD, using a seed-based approach. Resting-state magnetic resonance images were obtained from 48 PTSD patients and 34 trauma-exposed healthy participants (TEHC). Results indicated no group differences when examining the hippocampus as a whole. However, examining the anterior and posterior hippocampus revealed a loss of anterior to posterior connectivity differentiation in PTSD patients. The PTSD group also demonstrated lower negative connectivity of the posterior hippocampus-precuneus pathway compared with the TEHC group. Finally, as differences in anterior and posterior hippocampus connectivity have been also related to age, we performed a secondary analysis exploring the association between age and posterior-and anterior-hippocampus connectivity in both groups. Results showed that among PTSD patients, increased age had the effect of normalizing posterior hippocampus-precuneus and hippocampus-posterior cingulate cortex connectivity, whereas no such effect was noted for the control group. These findings highlight the need for PTSD connectivity research to consider sub-parts of the hippocampus and to account for age-related connectivity differences.

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Section: Discussionsupporting

confidence: 61%

Section: Methodsmentioning

confidence: 99%

Resting-state functional connectivity of anterior and posterior hippocampus in posttraumatic stress disorder

Lazarov

Lee

Suarez‐Jimenez

et al. 2017

Journal of Psychiatric Research

Self Cite

View full text Add to dashboard Cite

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“…All functional images were slice-time and motion corrected, co-registered to each participant=s T1-weighted structural image, normalized to Montreal Neurological Institute (MNI) canonical template, and smoothed with an 8 mm full-width-at-half-maximum (FWHM) Gaussian kernel (Zhu et al, 2016). …”

Section: Methodsmentioning

confidence: 99%

Exposure-based therapy changes amygdala and hippocampus resting-state functional connectivity in patients with posttraumatic stress disorder

et al. 2018

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“…Third, happy face stimuli also relevant to the construct of dysphoria symptoms have been found to engage regions central to the positive affect, or reward, circuits of the human brain (Whitton, Treadway, & Pizzagalli, 2015). In PTSD, we have observed reduced activation of these same regions when probed by happy face stimuli and reduced reward‐related striatal and subcortical connectivity (K. L. Felmingham et al, 2014; Zhu et al, 2017).…”

Section: Introductionmentioning

confidence: 97%

Differential neural predictors of treatment response for fear and dysphoric features of posttraumatic stress disorder

et al. 2020

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Background: Although trauma-focused cognitive behavioral therapy (TF-CBT) is the frontline treatment for posttraumatic stress disorder (PTSD), at least one-third of patients are treatment nonresponders. This study aimed to identify neural markers of treatment response, specifically the prediction of remission of specific PTSD symptoms. Methods: This study assessed PTSD treatment-seeking patients (n = 40) before TF-CBT during functional magnetic brain resonance imaging (fMRI) when they processed fearful, sad, happy, and neutral faces. Patients underwent nine sessions of TF-CBT and were independently assessed on the Clinician-Administered PTSD Scale (CAPS) following treatment. Treatment responders and nonresponders were compared with healthy controls (n = 40). The severity of PTSD was assessed with the CAPS. fMRI responses were calculated for each emotion face compared to neutral contrast, which were correlated with reduction in PTSD severity from pretreatment to posttreatment. Treatment response was categorized by at least 50% reduction in the severity of PTSD. Results: The activation of left insula during the processing of both sad and fearful faces was associated with a greater reduction of fear but not with dysphoric symptoms after treatment. Connectivity of the left insula to the pregenual anterior cingulate cortex was associated with poorer response to treatment. Responders and controllers had similar levels of activation and connectivity and were different from nonresponders. Conclusions: Positive response to TF-CBT is predicted during emotion processing by normal levels of recruitment of neural networks implicated in emotional information. These findings suggest that distinct neural networks are predictive of PTSD fear and dysphoric symptom reduction following TF-CBT.

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Altered resting state functional connectivity of fear and reward circuitry in comorbid PTSD and major depression

Cited by 74 publications

References 61 publications

Resting-state functional connectivity of anterior and posterior hippocampus in posttraumatic stress disorder

Resting-state functional connectivity of anterior and posterior hippocampus in posttraumatic stress disorder

Exposure-based therapy changes amygdala and hippocampus resting-state functional connectivity in patients with posttraumatic stress disorder

Differential neural predictors of treatment response for fear and dysphoric features of posttraumatic stress disorder

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