Altered response of human umbilical artery to 5-HT in gestational diabetic pregnancy

Radenković, Miroslav; Radunović, Nebojša; Momcilov, P.; Grbović, Leposava

doi:10.1016/s1734-1140(09)70095-7

Cited by 11 publications

(11 citation statements)

References 20 publications

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“…The K ATP blocker glibenclamide (1 mmol/L) had no effect in HUA rings when applied on top of bradykinin- 24 or serotonin-induced contractions. 21 Moreover, glibenclamide (10 mmol/L) did not modify NO-or levosimendan-induced relaxations, ruling out the participation of K ATP in such contractile and relaxing mechanisms. 15,17 The K ATP channels have also been looked for in primary cultured HUASMCs.…”

Section: Intracellular Events Cell Event Vessel Eventsmentioning

confidence: 89%

“…For instance, Radenkovic et al have reported that in HUA coming from neonates whose mothers presented pregnancy-induced hypertension, the BK Ca channels seem to have a different role in bradykinin-developed force than the HUA from normal pregnancies, because 0.5 mmol/L TEA increased bradykinin contractions in the former case, while it did not affect HUA from normotensive pregnancies. 21 In placental vessels, BK Ca channel expression has also been demonstrated by electrophysiological techniques 22 and by RT-PCR and Western blotting. 8 Similar to what occurs in HUA, these channels seem to be involved in NO-induced vascular relaxation 23 and attenuate agonist-induced contractions in placental vessels.…”

Section: Intracellular Events Cell Event Vessel Eventsmentioning

confidence: 99%

“…32,33 In particular, it has been reported that the role of K IR and BK Ca channels may be altered in HUA coming from gestational diabetes mellitus and pregnancy-induced hypertension, respectively. 21 More investigation on human umbilical cord vessels is needed to complete the knowledge in this important field of human health, taking into account that in the past years there are many reports that indicate that the fetal environment could determine the presentation of adult cardiovascular diseases. 34 …”

Section: Implication Of K þ Channels In Pregnancy-related Pathologiesmentioning

confidence: 99%

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Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction

et al. 2014

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Through their control of cell membrane potential, potassium (K þ ) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K þ channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage-and Ca 2þ -sensitive K þ channel and voltage-dependent K þ channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca 2þ -sensitive K þ channels, 2-pore domains K þ channels and inward rectifier K þ channels also appear to be present in HUASMCs, while intermediate conductance Ca 2þ -sensitive K þ channels and ATP-sensitive K þ channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K þ channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.

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Section: Intracellular Events Cell Event Vessel Eventsmentioning

confidence: 89%

Section: Intracellular Events Cell Event Vessel Eventsmentioning

confidence: 99%

Section: Implication Of K þ Channels In Pregnancy-related Pathologiesmentioning

confidence: 99%

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Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction

et al. 2014

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“…A major physiological event in the vascular smooth muscle cell contraction is an increase in intracellular calcium concentration via either the release from intracellular stores and/or from influx from the extracellular space [20]. The contribution of extracellular calcium on the carotid artery response to serotonin was evaluated by pretreatment of vascular preparations with nifedipine, a voltage-gated L-type Ca 2+ channel blocker.…”

Section: Discussionmentioning

confidence: 99%

Contribution of Thromboxane A2 in Rat Common Carotid Artery Response to Serotonin

Radenković

Stojanović²,

Topalović³

2010

Sci. Pharm.

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Serotonin is a vasoactive substance that in different blood vessels mostly induces vasoconstriction. Considering the important role of common carotid artery in brain blood supply, the aims of this study were to investigate the effect of serotonin on isolated rat common carotid artery and also to examine participation of intact endothelium, cyclooxygenase products, Ca++ channels and 5-HT2 receptors in serotonin-evoked action. Endothelium was mechanically removed from some vascular rings. Circular artery segments were placed in organ baths containing Krebs–Ringer bicarbonate solution. Cumulative concentration-contraction curves for serotonin were obtained in rings previously equilibrated at basal tone. Serotonin produced concentration-dependent contraction, which was unaltered by endothelial denudation. Serotonin-induced effect was notably and comparably reduced by indomethacin (cyclooxygenase inhibitor) or OKY–046 (thromboxane A2-synthase inhibitor) on intact or denuded rings. Nifedipine (Ca++ channel blocker) or ketanserin (5-HT2 receptor antagonist) strongly reduced serotonin-evoked effect. Our results suggest that serotonin produced concentration-dependent and endothelium-independent contraction of carotid artery, which was initiated by activation of 5-HT2 receptors located on smooth muscle cells and mediated via L-type Ca++ channels. Thromboxane A2 from smooth muscle cells notably contributed to the overall contraction of carotid artery induced by serotonin.

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“…ED associated with different pathological conditions include chronic heart failure, acute coronary syndrome, cardiac syndrome X, hypertension, impaired glucose tolerance (IGT), type 2 diabetes, obesity, peripheral artery disease (PAD), Behçet's disease, polycystic ovary syndrome, ankylosing spondylitis, subclinical hypothyroidism, chronic haemodialysis and hypertension or diabetes in pregnancy491314. Since ED may be a reversible process, there is an increased interest in investigation of different non-pharmacological and pharmacological methods that could improve endothelial function.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin receptor blockers & endothelial dysfunction: Possible correlation & therapeutic implications

et al. 2016

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The endothelium is one of the most important constituents of vascular homeostasis, which is achieved through continual and balanced production of different relaxing and contractile factors. When there is a pathological disturbance in release of these products, endothelial dysfunction (ED) will probably occur. ED is considered to be the initial step in the development of atherosclerosis. This pathological activation and inadequate functioning of endothelial cells was shown to be to some extent a reversible process, which all together resulted in increased interest in investigation of different beneficial treatment options. To this point, the pharmacological approach, including for example, the use of angiotensin-converting enzyme inhibitors or statins, was clearly shown to be effective in the improvement of ED. One of many critical issues underlying ED represents instability in the balance between nitric oxide and angiotensin II (Ang II) production. Considering that Ang II was confirmed to be important for the development of ED, the aim of this review article was to summarize the findings of up to date clinical studies associated with therapeutic application of angiotensin receptor blockers and improvement in ED. In addition, it was of interest to review the pleiotropic actions of angiotensin receptor blockers linked to the improvement of ED. The prospective, randomized, double-blind, placebo or active-controlled clinical trials were identified and selected for the final evaluation.

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Altered response of human umbilical artery to 5-HT in gestational diabetic pregnancy

Cited by 11 publications

References 20 publications

Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction

Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction

Contribution of Thromboxane A2 in Rat Common Carotid Artery Response to Serotonin

Angiotensin receptor blockers & endothelial dysfunction: Possible correlation & therapeutic implications

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