Altered regional homogeneity and cognitive impairments in first-episode schizophrenia: A resting-state fMRI study

Huang, Yuyan; Wang, Weiyan; Hei, Gangrui; Yang, Ye; Long, Yujun; Wang, Xiaoyi; Xiao, Jianru; Xu, Xijia; Song, Xueqin; Gao, Shuzhan; Shao, Tiannan; Huang, Jing; Wang, Ying; Zhao, Jingping; Wu, Renrong

doi:10.1016/j.ajp.2022.103055

Cited by 18 publications

(12 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was also shown that multiple sclerosis patients with worsened cognition had more severe gray matter atrophy in right anterior cingulate cortex compared to cognitively stable multiple sclerosis patients [48]. Additionally, ReHo in right anterior cingulate cortex has been found to be negatively correlated with working memory in schizophrenia patients [45]. In PD patients, blood perfusion was significantly decreased in right anterior cingulate cortex compared with the normal controls [49].…”

Section: Discussionmentioning

confidence: 99%

Structural network topology correlates with cognitive impairment in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

View full text Add to dashboard Cite

In patients with Parkinson's disease (PD), cognitive impairment is common and substantially exacerbates disease severity. The objective of this study is to investigate whether cognitive decline affects disease severity and whether structural network disruption contributes to cognitive impairment in PD patients. PD patients (n = 146) receiving structural and functional magnetic resonance imaging from Parkinson's Progression Markers Initiative (PPMI) database were included. Based on the scores of Symbol Digit Modalities Test (SDMT), patients were classified into lower quartile group (SDMT score rank: 0%~25%), interquartile group (SDMT score rank: 26%~75%), and upper quartile group (SDMT score rank: 76%~100%) according to their SDMT score quartiles to assess how cognitive function shapes disease manifestations and brain network topology. Patients in the lower quartile group exhibited more severe motor symptoms, non-motor symptoms, and striatal dopamine depletion compared to interquartile group and upper quartile group. In addition, they also showed impaired structural network topology both at global and local levels compared to interquartile group and upper quartile group. Furthermore, different nodal network metrics in structural network contributed to cognitive and motor impairment of PD patients. Taken together, PD patients with worse cognitive function exhibited more severe motor and non-motor symptoms and aberrant structural network metrics were associated with both cognitive and motor decline of PD patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Structural network topology correlates with cognitive impairment in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Furthermore, patients with schizophrenia showed elevated regional homogeneity values in the prefrontal cortex ( Shan et al, 2021 ), inferior parietal lobule, precuneus/cuneus ( Zhao et al, 2019 ), cerebellum, as well as decreased regional homogeneity values in the temporal lobule, medial prefrontal gurus ( Shan et al, 2021 ), inferior parietal lobule ( Zhao et al, 2018 ), precuneus ( Yan et al, 2020 ), and occipital lobule ( Gao et al, 2018 ). Regional homogeneity and cognitive dysfunction were recently linked in a large study by Huang et al (2022) of first-episode schizophrenia patients. They showed that in patients with schizophrenia, regional homogeneity values were increased in the right superior frontal gyrus and decreased in the left anterior cingulate gyrus, right middle occipital gyrus, left cuneus, and right superior occipital gyrus.…”

Section: Imagingmentioning

confidence: 99%

Neuroimaging in schizophrenia: A review article

et al. 2022

View full text Add to dashboard Cite

In this review article we have consolidated the imaging literature of patients with schizophrenia across the full spectrum of modalities in radiology including computed tomography (CT), morphologic magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), positron emission tomography (PET), and magnetoencephalography (MEG). We look at the impact of various subtypes of schizophrenia on imaging findings and the changes that occur with medical and transcranial magnetic stimulation (TMS) therapy. Our goal was a comprehensive multimodality summary of the findings of state-of-the-art imaging in untreated and treated patients with schizophrenia. Clinical imaging in schizophrenia is used to exclude structural lesions which may produce symptoms that may mimic those of patients with schizophrenia. Nonetheless one finds global volume loss in the brains of patients with schizophrenia with associated increased cerebrospinal fluid (CSF) volume and decreased gray matter volume. These features may be influenced by the duration of disease and or medication use. For functional studies, be they fluorodeoxyglucose positron emission tomography (FDG PET), rs-fMRI, task-based fMRI, diffusion tensor imaging (DTI) or MEG there generally is hypoactivation and disconnection between brain regions. However, these findings may vary depending upon the negative or positive symptomatology manifested in the patients. MR spectroscopy generally shows low N-acetylaspartate from neuronal loss and low glutamine (a neuroexcitatory marker) but glutathione may be elevated, particularly in non-treatment responders. The literature in schizophrenia is difficult to evaluate because age, gender, symptomatology, comorbidities, therapy use, disease duration, substance abuse, and coexisting other psychiatric disorders have not been adequately controlled for, even in large studies and meta-analyses.

show abstract

“…According to this method, previous studies have indicated the presence of widespread ReHo abnormalities in mental disorders. For example, compared to healthy controls, patients with schizophrenia exhibit increased ReHo values in the right frontal cortex 24 or in regions of the somatosensory and perception networks 25 , and decreased ReHo values in regions of the visual cortex 26 . However, to our knowledge, there is currently no research on ReHo in psychotic depression.…”

Section: Introductionmentioning

confidence: 99%

Differences of regional homogeneity and cognitive function between psychotic depression and drug-naïve schizophrenia

Chen

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Psychotic depression (PD) and schizophrenia (SCZ) are disorders with shared symptoms but unique causes, development, and treatments. Identifying them based on symptoms is difficult, requiring deeper comprehension of cognitive and neural mechanisms for accurate diagnosis and treatment. Aim: This study aims to compare cognitive impairments and brain functional activities in PD and SCZ, in order to identify unique features of each disorder. Methods: We studied 42 PD and 30 SCZ patients using RBANS and rs-fMRI. We computed ReHo values from the rs-fMRI data and compared RBANS scores between groups. We also investigated the correlation between cognition and brain function using Pearson analysis. Results: (1) SC group had lower RBANS scores than PD group in all test sections; (2) Left precuneus had significant ReHo difference between PD and SC groups, with SCZ group showing significantly increased ReHo (p < 0.05); (3) Negative correlation found between visuospatial construction score, delayed memory score and ReHo value of left precuneus by Pearson correlation analysis. conclusion: Cognitive impairment is more severe in SCZ than PD. Elevated left precuneus activity distinguishes PD from SCZ and relates to cognitive deficits in both, offering neuroimaging evidence for differential diagnosis and insight into cognitive impairment pathology.

show abstract

Altered regional homogeneity and cognitive impairments in first-episode schizophrenia: A resting-state fMRI study

Cited by 18 publications

References 61 publications

Structural network topology correlates with cognitive impairment in Parkinson’s disease

Structural network topology correlates with cognitive impairment in Parkinson’s disease

Neuroimaging in schizophrenia: A review article

Differences of regional homogeneity and cognitive function between psychotic depression and drug-naïve schizophrenia

Contact Info

Product

Resources

About