Altered Rectal Perception in Irritable Bowel Syndrome Is Associated With Symptom Severity

Posserud, Iris; Syrous, Alma Nordenskjöld; Lindström, Lars; Tack, Jan; Abrahamsson, Hasse; Simrén, Magnus

doi:10.1053/j.gastro.2007.07.024

Cited by 222 publications

(268 citation statements)

References 62 publications

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“…Visceral hypersensitivity is a biological marker in some IBS cases, especially D-IBS patients. In contrast to Posserud et al (2007), we found no gender difference in the visceral hypersensitivity. Gender distribution was balanced in our IBS group, while Posserud et al (2007)'s group was composed of almost all women.…”

Section: Discussioncontrasting

confidence: 99%

“…In contrast to Posserud et al (2007), we found no gender difference in the visceral hypersensitivity. Gender distribution was balanced in our IBS group, while Posserud et al (2007)'s group was composed of almost all women. This may have caused a gender bias, and so comparisons with our study may be inappropriate.…”

Section: Discussioncontrasting

confidence: 99%

“…Sometimes, this is unavoidable in reallife clinical research, but no significant effects of gender were found in our two groups. Furthermore, age difference is not an influential factor in the evaluation of experimental parameters such as visceral hypersensitivity (Posserud et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction and low-grade inflammation in a subset of irritable bowel syndrome patients

Liu

Chen

et al. 2014

J. Zhejiang Univ. Sci. B

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Abstract:The pathophysiology of irritable bowel syndrome (IBS) is complex and not fully understood, so the aim of this study was to evaluate whether visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction, and low-grade inflammation of the gut wall are associated with diarrhea-predominant IBS (D-IBS). Sixty-two patients with D-IBS and 20 control subjects participated in the study. Using the ascending method of limits (AML) protocol, we demonstrated that D-IBS patients had significantly lower sensory thresholds compared with healthy controls (P<0.001). Using diverse methods, especially the ischemic sensitivity test, for the first time in China, we confirmed that D-IBS patients have somatic hypersensitivity. They had a significantly higher systolic blood pressure and heart rate after a cold stimulus, indicative of autonomic cardiovascular dysfunction. Compared with the control group, D-IBS patients had a significantly higher level of calprotectin (P<0.001). We also found significant correlations between visceral and somatic hypersensitivity, visceral hypersensitivity and autonomic cardiovascular dysfunction, and somatic hypersensitivity and autonomic cardiovascular dysfunction. Our findings may provide valuable suggestions for the treatment of D-IBS.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

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Visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction and low-grade inflammation in a subset of irritable bowel syndrome patients

Liu

Chen

et al. 2014

J. Zhejiang Univ. Sci. B

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“…9,[15][16][17][18][19] The barostat was programmed to deliver a series of phasic isobaric rectal distensions 60 s in duration, separated by 60 s periods, during which bag pressure returned to the IOP. Distension stimuli were programmed to increase by 4 mmHg with each distension until the subject reported pain.…”

Section: Distension Protocolmentioning

confidence: 99%

Rectal hyposensitivity for non-noxious stimuli, postprandial hypersensitivity and its correlation with symptoms in complete spinal cord injury with neurogenic bowel dysfunction

et al. 2012

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Study design: Prospective clinical study. Objectives: To assess fasting and postprandial (PP) perception of rectal distension and its correlation with symptoms in patients with spinal cord injury (SCI) and neurogenic bowel dysfunction compared to ten healthy subjects (HS). Setting: Experimental Medicine and Motility Unit, Mexico General Hospital and National Institute of Rehabilitation. Methods: Twenty patients with complete SCI at cervical, thoracic and lumbar levels [American Spinal Injury Association (ASIA) A] were studied. Rectal sensitivity was evaluated with a barostat. Results: In SCI patients, while lower the rectal tone more time was used for defecate (R ¼ 0.50, P ¼ 0.048) and more PP episodes of fecal incontinence occur (R ¼ 0.54, P ¼ 0.030). The thresholds for non-noxious stimuli of first (23.6 mmHg, CI 19.5-27.7) vs 14.0 (CI 10.9-17.1), P ¼ 0.004; gas (27.9 mmHg, CI 19.9-35.8) vs 17.9 mmHg (CI 14.25-21.69), P ¼ 0.02 and urge-to-defecate sensation (33.2 mmHg, CI 27.5-38.8) vs 22.4 mmHg (CI 17.9-26.9), P ¼ 0.01 were reported by SCI patients at higher pressure than HS, respectively. SCI patients reported PP pain sensation at a lower pressure than controls (27.8 mmHg, CI 21.5-34.2 vs 36.5 mmHg, CI 31.8-41.2), P ¼ 0.04. Conclusion: SCI patients preserve rectal sensation, present rectal hyposensitivity for non-noxious stimuli and PP hypersensitivity. Lower rectal tone was related to the time used for defecate and with fecal incontinence. The results suggest that an intact neural transmission between the spinal cord and higher centres is indispensable for noxious stimulus, but not for non-noxious stimuli. Also, barostat sensitivity studies can complement ASIA criteria to verify a complete injury. Spinal Cord (2013) 51, 94-98;

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“…2,24 Visceral hyperalgesia has long been considered to be a diagnostic marker of both pediatric and adult IBS and a majority of patients show increased sensitivity to controlled rectal distension compared to healthy controls. 7,14,31,33,38,44,52 Though this finding could be explained by both local tissue pathology and altered processing at the primary afferent, studies have also reported increased sensitivity for different experimental pain stimuli at distal body sites (e.g. heat, cold-pressor and pressure pain).…”

Section: Introductionmentioning

confidence: 99%

Widespread Hyperalgesia in Adolescents With Symptoms of Irritable Bowel Syndrome: Results From a Large Population-Based Study

Stabell

Stubhaug

Flægstad

et al. 2014

The Journal of Pain

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Altered Rectal Perception in Irritable Bowel Syndrome Is Associated With Symptom Severity

Cited by 222 publications

References 62 publications

Visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction and low-grade inflammation in a subset of irritable bowel syndrome patients

Visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction and low-grade inflammation in a subset of irritable bowel syndrome patients

Rectal hyposensitivity for non-noxious stimuli, postprandial hypersensitivity and its correlation with symptoms in complete spinal cord injury with neurogenic bowel dysfunction

Widespread Hyperalgesia in Adolescents With Symptoms of Irritable Bowel Syndrome: Results From a Large Population-Based Study

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