Altered reactivity to threatening stimuli inDrosophilamodels of Parkinson’s disease, revealed by a trial-based assay
Márton Kajtor,
Viktor A. Billes,
Bálint Király
et al.
Abstract:The fruit fly Drosophila melanogaster emerges as an affordable, genetically tractable model of behavior and brain diseases. However, despite the surprising level of evolutionary conservation from flies to humans, significant genetic and circuit-level differences hinder the interpretability of fruit fly models for human disease. Therefore, to facilitate fly-to-human translation with more direct behavior-level comparison, we surveyed the rarely-exploited, rich behavioral repertoire of fruit flies with genetic al… Show more
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