Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection

Wang, Xiuxing; Ying, Pu; Diao, Fan; Wang, Qiang; Ye, Dan; Chen, Jiang; Shen, Ning; Xu, Na; Chen, Weibo; Lai, Shanshan; Jiang, Shan; Miao, Xiao-Li; Jin, Feng; Tao, Weiwei; Zhao, Ningwei; Yao, Bing; Xu, Zhipeng; Sun, Haixiang; Li, Jianmin; Sha, Jiahao; Huang, Xingxu; Shi, Qinghua; Tang, Hong; Gao, Xiang; Li, Chao‐Jun

doi:10.1084/jem.20121806

Cited by 59 publications

(75 citation statements)

References 51 publications

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“…[34][35][36][37] Three of the four studies used an RCT study design with low risk for bias, and the fourth used a post-test only design. All four studies found that exposure to the parenting intervention was associated with improved short-term outcomes (i.e., parent-child communication, youth's condom use skills and selfefficacy, communication openness).…”

Section: Discussionmentioning

confidence: 99%

Programs to Strengthen Parent–Adolescent Communication About Reproductive Health

Gavin¹,

Williams²,

Rivera³

et al. 2015

American Journal of Preventive Medicine

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Section: Discussionmentioning

confidence: 99%

Programs to Strengthen Parent–Adolescent Communication About Reproductive Health

Gavin¹,

Williams²,

Rivera³

et al. 2015

American Journal of Preventive Medicine

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“…Various infections can also lead to gonadal insufficiency; for example, mumps results in orchitis in select patients. The mechanism leading to decreased fertility is thought to be due to viral infection of the testicular tissue and resultant damage to the Sertoli and Leydig cells as well as testicular atrophy, however this is not completely understood (69)(70)(71). Approximately 13% of patients with mumps orchitis will have resultant subfertility, with infertility in a subset of these patients (71).…”

Section: Other Causes Of Gonadal Dysfunctionmentioning

confidence: 99%

Fertility counseling and preservation: considerations for the pediatric endocrinologist

Saraf

Nahata

2017

Transl. Pediatr

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Infertility is a distressing consequence of numerous pediatric medical conditions and treatments.The field of pediatric fertility preservation has expanded rapidly over the past decade, and clinical guidelines emphasize the importance of discussing infertility risk and fertility preservation options with patients and families in a timely manner. Understanding the various mechanisms and presentations of fertility issues across diagnoses is imperative to provide counseling to patients and families, and identify individuals who may benefit from fertility preservation. The goals of this manuscript are to outline current fertility preservation options in pediatrics, review populations at-risk for infertility that are seen in pediatric endocrinology, and discuss other important issues related to fertility preservation including ethical considerations.

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“…These inflammatory factors then bound to the receptors on spermatogonia and activated cell apoptosis signaling pathway, leading to a long-term effect on adult infertility [35,36]. Macrophages could be recruited by chemokines, easily invade the testicular tubules and attack developing spermatogonium cells, resulting in spermatogonia apoptosis [37].…”

Section: The Ras Prenylation and Male Infertilitymentioning

confidence: 99%

Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation

Shen

Wang

et al. 2015

Sci. China Life Sci.

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The protein prenylation is one of the essential post-translational protein modifications, which extensively exists in the eukaryocyte. It includes protein farnesylation and geranylgeranylation, using farnesyl pyrophosphate (FPP) or geranylgeranyl pyrophosphate (GGPP) as the substrate, respectively. The prenylation occurs by covalent addition of these two types of isoprenoids to cysteine residues at or near the carboxyl terminus of the proteins that possess CaaX motif, such as Ras small GTPase family. The attachment of hydrophobic prenyl groups can anchor the proteins to intracellular membranes and trigger downstream cell signaling pathway. Geranylgeranyl biphosphate synthase (GGPPS) catalyzes the synthesis of 20-carbon GGPP from 15-carbon FPP. The abnormal expression of this enzyme will affect the relative content of FPP and GGPP, and thus disrupts the balance between protein farnesylation and geranylgeranylation, which participates into various aspects of cellular physiology and pathology. In this paper, we mainly review the property of this important protein post-translational modification and research progress in its regulation of cigarette smoke induced pulmonary disease, adipocyte insulin sensitivity, the inflammation response of Sertoli cells, the hepatic lipogenesis and the cardiac hypertrophy. protein prenylation, GGPP, FPP, biological function regulation Citation:Xu N, Shen N, Wang XX, Jiang S, Xue B, Li CJ. Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation.

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Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection

Abstract: Loss of GGPPS from childhood mumps infection or deletion in mice results in constitutively activated MAPK and NF-kB signaling that induces spermatogonium apoptosis, macrophage invasion into seminiferous tubules, and sterility.

Cited by 59 publications

References 51 publications

Programs to Strengthen Parent–Adolescent Communication About Reproductive Health

Programs to Strengthen Parent–Adolescent Communication About Reproductive Health

Fertility counseling and preservation: considerations for the pediatric endocrinologist

Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation

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