Altered Prevalence of Pulp Diagnoses in Diabetes Mellitus Patients: A Retrospective Study

Marrero, Yandy Gonzalez; Kobayashi, Yoshifumi; Ihsan, Saqib; Pilch, Lisa; Chen, Liyaa; Jiang, Shuying; Ye, Yi; Fine, Daniel H.; Falcon, Carla; Falcon, Paul A.; Hirschberg, Craig; Shimizu, Emi

doi:10.1016/j.joen.2021.11.001

Cited by 7 publications

(4 citation statements)

References 25 publications

(19 reference statements)

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Section: Discussionmentioning

confidence: 99%

“…Whilst an increasing number of observational studies have explored the association between pulp and periapical disease and type 2 diabetes mellitus, the link between the two conditions remains controversial (Gonzalez Marrero et al, 2022;López-López et al, 2011;Marotta et al, 2012;Mesgarani et al, 2014;Smadi, 2017). López-López et al (2011) investigated the prevalence of endodontic treatment and apical periodontitis (AP) in type 2 diabetes mellitus patients, the results suggested T2DM was significantly linked with an increase of the number of root-filled teeth (OR = 1.7, p = .0035) and the prevalence of apical periodontitis (OR = 3.3, p = .0071) in adults.…”

Section: Discussionmentioning

confidence: 99%

“…A cross‐sectional study also suggested that apical periodontitis was more prevalent in untreated teeth of T2DM, whereas the results revealed type 2 diabetes might not impact root canal treatment (Marotta et al., 2012). A retrospective study proposed finding about symptomatic irreversible pulpitis was significantly higher in diabetes mellitus patients compare with control group amongst <40 years old individuals (Gonzalez Marrero et al., 2022). Moreover, Mesgarani et al.…”

Section: Discussionmentioning

confidence: 99%

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Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization

Wang,

Zhu,

Tang

et al. 2024

Int Endodontic J

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AimThis current Mendelian randomization (MR) study aims to comprehensively explore the potential bidirectional link between pulp and periapical disease (PAP) with type 2 diabetes mellitus (T2DM).MethodologySummary level data of European‐based population genome‐wide association studies (GWASs) were employed to undertake this MR study. With the selection of single nucleotide polymorphisms (SNPs) as the instrumental variable, the radial inverse‐variance weighted (radial IVW) method with modified second‐order weights was applied as the primary method. Additionally, a range of sensitivity analyses were conducted to investigate pleiotropy. Results from different sources of outcome were pooled by meta‐analysis with the fixed model.ResultsThe results of this MR analysis did not suggest a significant impact of pulp and periapical disease on type 2 diabetes (combined OR = 1.04, 95% CI: 1.00–1.07, p = .033) and vice versa (OR = 1.04, 95% CI: 0.96–1.14, p = .329). No significant pleiotropy was detected in the final model after the removal of outliers, demonstrating the reliability of the results in our primary analysis.ConclusionsWith the limitations inherent in the present MR study, there is no significant evidence in either direction to suggest a causal association between pulp and periapical disease and type 2 diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization

Wang,

Zhu,

Tang

et al. 2024

Int Endodontic J

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“…Poor control of diabetes leads to impairment of dental collateral circulation and immune response (Lima et al., 2013). Patients with diabetes under 40 years of age have a markedly higher prevalence of symptomatic irreversible pulpitis than healthy individuals (Gonzalez Marrero et al., 2022). In a diabetic rat model, the volume density of collagen fibers in the dental pulp was significantly reduced and the inflammatory cell volume density was increased (Claudino et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

Type 2 diabetes aggravates periodontitis‐induced pathological changes in the dental pulp

Yang,

Zhou,

Shan

et al. 2023

Oral Diseases

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ObjectivesThe inner mechanism of how diabetes affects dental pulp of patients with periodontitis has seldom been reported. We collected clinical samples and explored the influence of diabetes and periodontitis on the pathological change of dental pulp.MethodsDental pulp from healthy individuals and patients with periodontitis with or without diabetes were collected based on strict inclusion and exclusion criteria. Dental pulp was morphologically observed; advanced glycation end products (AGEs) and lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX1) were examined. Oxidative stress (OS), inflammatory indices, and apoptotic levels were assessed.ResultsMorphologically, fibrous structure in the dental pulp of patients with diabetic periodontitis (DP) group was sparse and disordered, and the blood vessel wall was thickened. Diabetes related indexes as AGEs and LOX1 were upregulated. Superoxide dismutase 2 expression was decreased, and OS level was increased. Matrix metalloproteinase 3 and other relevant proinflammatory cytokines levels were increased. The elevated OS and inflammation contributed to upregulation of apoptotic levels in DP group.ConclusionsDiabetes aggravates the pathological changes in the dental pulp of periodontitis patients possibly due to upregulated AGEs and LOX1. Our results highlight the importance of early oral intervention in patients with DP.

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Insights into the February 2022 Issue of the JOE

Aminoshariae

Azarpazhooh

Diogenes

et al. 2022

Journal of Endodontics

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Altered Prevalence of Pulp Diagnoses in Diabetes Mellitus Patients: A Retrospective Study

Cited by 7 publications

References 25 publications

Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization

Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization

Type 2 diabetes aggravates periodontitis‐induced pathological changes in the dental pulp

Insights into the February 2022 Issue of the JOE

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