Altered Potassium Channel Expression in the Human Placental Vasculature of Pregnancies Complicated by Fetal Growth Restriction

Corcoran, Jemma J.; Lacey, H; Baker, Philip N.; Wareing, Mark

doi:10.1080/10641950701826158

Cited by 16 publications

(12 citation statements)

References 38 publications

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“… G, gene; R, mRNA; P, protein; 1, Amberg and Santana (2006) ; 2, Archer et al (2004) ; 3, Bergren et al (2009) ; 4, Bocksteins et al (2009) ; 5, Brahmajothi et al (1996) ; 6, Castellano et al (1997) ; 7, Chen et al (2010) ; 8, Cioli et al (2014) ; 9, Corcoran et al (2008) ; 10, Costigan et al (2010) ; 11, Czirják et al (2007) ; 12, Davies and Kozlowski (2001) ; 13, Drewe et al (1992) ; 14, Georgiev et al (2012) ; 15, Georgiev et al (2014) ; 16, Fantozzi et al (2006) ; 17, Firth et al (2011) ; 18, Friedland et al (2007) ; 19, Friedman et al (2013) ; 20, Fyfe et al (2012) ; 21, Hayama et al (2006) ; 22, Hölter et al (2012) ; 23, Hugnot et al (1996) ; 24, Jorge et al (2011) ; 25, Hristov et al (2012b) ; 26, Hristov et al (2012a) ; 27, Lee et al (2003) ; 28, Lee et al (2015) ; 29, Li et al (2015) ; 30, Mederos y Schnitzler et al (2009) ; 31, Moreno-Domínguez et al (2009) ; 32, Müller et al (2014) ; 33, Ottschytsch et al (2002) ; 34, Patel et al (1997) ; 35, Platoshyn et al (2004) ; 36, Rao et al (2002) ; 37, Salinas et al (1997b) ; 38, Sandberg et al (2014) ; 39, Sano et al (2002a) ; 40, Sano et al (2002b) ; 41, Shepard and Rae (1999) ; 42, Spitzner et al (2007) ; 43, Stocker and Kerschensteiner (1998) ; 44, Su et al (1997) ; 45, Suzuki and Takimoto (2004) ; 46, Thorneloe and Nelson (2003) ; 47, Tsantoulas et al (2012) ; 48, …”

Section: Physiological Role Of Kv2/kvs Heterotetramers In Different Tmentioning

confidence: 99%

Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders

Bocksteins

2016

Journal of General Physiology

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Members of the electrically silent voltage-gated K+ (Kv) subfamilies (Kv5, Kv6, Kv8, and Kv9, collectively identified as electrically silent voltage-gated K+ channel [KvS] subunits) do not form functional homotetrameric channels but assemble with Kv2 subunits into heterotetrameric Kv2/KvS channels with unique biophysical properties. Unlike the ubiquitously expressed Kv2 subunits, KvS subunits show a more restricted expression. This raises the possibility that Kv2/KvS heterotetramers have tissue-specific functions, making them potential targets for the development of novel therapeutic strategies. Here, I provide an overview of the expression of KvS subunits in different tissues and discuss their proposed role in various physiological and pathophysiological processes. This overview demonstrates the importance of KvS subunits and Kv2/KvS heterotetramers in vivo and the importance of considering KvS subunits and Kv2/KvS heterotetramers in the development of novel treatments.

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Section: Physiological Role Of Kv2/kvs Heterotetramers In Different Tmentioning

confidence: 99%

Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders

Bocksteins

2016

Journal of General Physiology

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“…Similar to other oxygen-sensitive vasculature, potassium channels are main determinants of vascular resistance (Wareing and Greenwood, 2011) and vasculogenesis (Brereton et al, 2013) in chorionic plate vessels. Previous studies have not been conclusive for the role of these channels in complicated pregnancies, but some authors suggests that K(V) may be involved in IUGR (Corcoran et al, 2008) and ROS might be regulating their function in the placenta (Mills et al, 2009), elevating vascular resistance. Furthermore, it has been shown that ROS enhanced basal tension and vasoconstriction in response to a thromboxane mimetic (Mills et al, 2009).…”

Section: Hypoxia and Oxidative Stressmentioning

confidence: 99%

The placental pursuit for an adequate oxidant balance between the mother and the fetus

et al. 2014

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The placenta is the exchange organ that regulates metabolic processes between the mother and her developing fetus. The adequate function of this organ is clearly vital for a physiologic gestational process and a healthy baby as final outcome. The umbilico-placental vasculature has the capacity to respond to variations in the materno-fetal milieu. Depending on the intensity and the extensity of the insult, these responses may be immediate-, mediate-, and long-lasting, deriving in potential morphostructural and functional changes later in life. These adjustments usually compensate the initial insults, but occasionally may switch to long-lasting remodeling and dysfunctional processes, arising maladaptation. One of the most challenging conditions in modern perinatology is hypoxia and oxidative stress during development, both disorders occurring in high-altitude and in low-altitude placental insufficiency. Hypoxia and oxidative stress may induce endothelial dysfunction and thus, reduction in the perfusion of the placenta and restriction in the fetal growth and development. This Review will focus on placental responses to hypoxic conditions, usually related with high-altitude and placental insufficiency, deriving in oxidative stress and vascular disorders, altering fetal and maternal health. Although day-to-day clinical practice, basic and clinical research are clearly providing evidence of the severe impact of oxygen deficiency and oxidative stress establishment during pregnancy, further research on umbilical and placental vascular function under these conditions is badly needed to clarify the myriad of questions still unsettled.

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“…28,29 Focusing on pregnancy-associated pathologies, K þ channels have been implicated in preeclampsia, gestational diabetes, and fetal growth restriction. The majority of these reports are focused on placenta, 30 fetoplacental vessels, 26 and maternal uterine vessels, 31 the knowledge of umbilical cord vessels being more scarce, regardless of the fact that their morphometric characteristics as well as blood flow parameters have been demonstrated to be altered in these pathologies. 32,33 In particular, it has been reported that the role of K IR and BK Ca channels may be altered in HUA coming from gestational diabetes mellitus and pregnancy-induced hypertension, respectively.…”

Section: Implication Of K þ Channels In Pregnancy-related Pathologiesmentioning

confidence: 99%

Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction

et al. 2014

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Through their control of cell membrane potential, potassium (K þ ) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K þ channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage-and Ca 2þ -sensitive K þ channel and voltage-dependent K þ channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca 2þ -sensitive K þ channels, 2-pore domains K þ channels and inward rectifier K þ channels also appear to be present in HUASMCs, while intermediate conductance Ca 2þ -sensitive K þ channels and ATP-sensitive K þ channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K þ channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.

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Altered Potassium Channel Expression in the Human Placental Vasculature of Pregnancies Complicated by Fetal Growth Restriction

Abstract: The gene expression of two voltage-gated K channels thought to be important for altered vascular reactivity following changes in oxygenation is increased in FGR.

Cited by 16 publications

References 38 publications

Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders

Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders

The placental pursuit for an adequate oxidant balance between the mother and the fetus

Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction

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