2017
DOI: 10.1016/j.expneurol.2016.10.013
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Altered postnatal maturation of striatal GABAergic interneurons in a phenotypic animal model of dystonia

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Cited by 30 publications
(18 citation statements)
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“…Among those are the fast spiking PV-positive GABAergic cells, known to play a major role in feedforward inhibition of GABAergic spiny projection neurons (Tepper et al, 2008 ). Although our recent study did not reveal any significant difference in the number of PV-positive GABAergic interneurons in the striatum of DYT-1 mice (Song et al, 2013 ), data from the d tsz hamster model of primary paroxysmal dystonia showed a significant and widespread loss, and maturation delay, of PV-positive striatal neurons (Gernert et al, 2000 ; Bode et al, 2017 ). Reiner et al ( 2013 ) recently suggested that the progressive loss of PV-positive neurons in the motor striatum may determine the timing of dystonia onset in a mouse model of Huntington’ disease.…”
Section: Discussionmentioning
confidence: 74%
“…Among those are the fast spiking PV-positive GABAergic cells, known to play a major role in feedforward inhibition of GABAergic spiny projection neurons (Tepper et al, 2008 ). Although our recent study did not reveal any significant difference in the number of PV-positive GABAergic interneurons in the striatum of DYT-1 mice (Song et al, 2013 ), data from the d tsz hamster model of primary paroxysmal dystonia showed a significant and widespread loss, and maturation delay, of PV-positive striatal neurons (Gernert et al, 2000 ; Bode et al, 2017 ). Reiner et al ( 2013 ) recently suggested that the progressive loss of PV-positive neurons in the motor striatum may determine the timing of dystonia onset in a mouse model of Huntington’ disease.…”
Section: Discussionmentioning
confidence: 74%
“…Patients with isolated dystonia had enhanced somatosensory temporal discrimination threshold and reduced suppression of paired-pulse SEPs ( 8 , 9 ), which were also observed in our patients who all presenting by paroxysmal dystonia. In the hamster model with the phenotype of dystonia, maturation of striatal GABAergic interneuron is delayed ( 53 ). Reduced functional connectivity of somatosensory network is involved in the pathomechanism of writer's cramp as well ( 54 ).…”
Section: Discussionmentioning
confidence: 99%
“…However, a sparing of parvalbumin neurons could be desirable not only for HD, but also in other hyperkinetic neurological disorders. Indeed, striatal parvalbumin expression is decreased in a dystonic hamster model (Bode et al, 2017 ). Thus, disorders where parvalbumin interneurons fast spiking activity is involved such as dystonia could benefit from such neuroprotective effect (Reiner et al, 2003 ).…”
Section: Discussionmentioning
confidence: 99%