Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression
FNU Jiamutai,
Abigail Hatfield,
Austin Herbert
et al.
Abstract:Alternative polyadenylation results in different 3’ isoforms of messenger RNA (mRNA) transcripts. Alternative polyadenylation in the 3’ untranslated region (3’UTR) can alter RNA localization, stability and translational efficiency. TheSERPINA1mRNA has two distinct 3’ UTR isoforms, both of which express the protease inhibitor α-1-antitrypsin (A1AT). A1AT is an acute phase protein that is expressed and secreted from liver hepatocytes and upregulated during inflammation. Low levels of A1AT in the lung contributes… Show more
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