Altered plasma response to zinc and iron tolerance test after Roux-en-Y gastric bypass

Rosa, Francisco Dalla; Oliveira-Penaforte, Fernanda Rodrigues de; Leme, Izabel de Arruda; Padovan, Gilberto João; Ceneviva, Reginaldo; Marchini, Júlio Sérgio

doi:10.1016/j.soard.2011.01.041

Cited by 19 publications

(7 citation statements)

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“…Taken together, bariatric surgery impedes the ability to absorb iron from both dietary sources and nutritional supplementation. To the best of our knowledge, five studies investigated the impact of bariatric surgery on iron absorption by comparing pre-and postoperative data (21,28,(46)(47)(48) . Ruz et al investigated the absorption of dietary iron after RYGB (n 36).…”

Section: Iron Absorption After Bariatric Surgerymentioning

confidence: 99%

Iron deficiency after bariatric surgery: what is the real problem?

et al. 2018

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The growing prevalence of obesity explains the rising interest in bariatric surgery. Compared with non-surgical treatment options, bariatric surgery results in greater and sustained improvements in weight loss, obesity associated complications, all-cause mortality and quality of life. These encouraging metabolic and weight effects come with a downside, namely the risk of nutritional deficiencies. Particularly striking is the risk to develop iron deficiency. Postoperatively, the prevalence of iron deficiency varies between 18 and 53 % after Roux-en-Y gastric bypass and between 1 and 54 % after sleeve gastrectomy. Therefore, preventive strategies and effective treatment options for iron deficiency are crucial to successfully manage the iron status of patients after bariatric surgery. With this review, we discuss the risks and the contributing factors of developing iron deficiency after bariatric surgery. Furthermore, we highlight the discrepancy in the diagnosis of iron deficiency, iron deficiency anaemia and anaemia and highlight the evidence supporting the current nutritional recommendations in the field of bariatric research. In conclusion, we advocate for more nutrition-related research in patient populations in order to provide strong evidence-based guidelines after bariatric surgery.

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Section: Iron Absorption After Bariatric Surgerymentioning

confidence: 99%

Iron deficiency after bariatric surgery: what is the real problem?

et al. 2018

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“…Despite the importance of minerals, few studies have reported urinary values for the elderly. Urinary values of minerals are usually correlated in different clinical conditions 2–4. However, data about urinary excretion in elderly subjects considered to be healthy are scarce, although knowledge about this topic is fundamental for the understanding of the kinetics and the age-related changes in the metabolism of these minerals.…”

Section: Introductionmentioning

confidence: 99%

Impact of Aging on Urinary Excretion of Iron and Zinc

Pfrimer

Micheletto

Marchini

et al. 2014

Nutr Metab Insights

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PROJECTData about the influence of aging on urinary excretion of iron and zinc are scarce. The objective of the present study was to compare the concentration of zinc and iron in the urine of healthy elderly subjects and younger adults.PROCEDURESeven healthy elderly subjects and seven younger adults were selected and submitted to biochemical, clinical, and nutritional tests. After a fasting period, 12-hour urine was collected for the determination of iron and zinc concentrations by graphite furnace atomic absorption spectrophotometry.RESULTSUrinary zinc and iron concentrations of the elderly subjects were not significantly different from that of younger adults. However, the total zinc and iron urinary clearance in 24 hours for the elderly was significantly higher compared with that of younger adults.CONCLUSIONThere is an increase in urinary iron and zinc clearance with aging. The values reported in this manuscript may be used as references in future studies.

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“…Rosa et al [19] found significantly reduced serum Zn levels 3 months after RYGB to an oral test dose of Zn with an 89 % reduction in the Serum Zn curve. Authors suggested that this indicated an impairment in Zn absorption after RYGB.…”

Section: Resultsmentioning

confidence: 97%

“…It is also evident that RYGB leads to not just a reduction in intake of Zn [15][16] but also its absorption [15,19]. In the study by Ruz et al [15], dietary Zn intake was 9.1, 5.4, 6.4, and 7.2 mg/d before and 6, 12, and 18 months respectively after RYGB.…”

Section: Resultsmentioning

confidence: 97%

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Zinc Deficiency after Gastric Bypass for Morbid Obesity: a Systematic Review

et al. 2016

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Usage guidelinesPlease refer to the usage guidelines at http://sure.sunderland.ac.uk/policies.html or alternatively contact sure@sunderland.ac.uk. 1 Abstract:Up to 50 % of patients have Zinc deficiency before bariatric surgery. Roux-en-Y Gastric Bypass (RYGB) is the commonest bariatric procedure worldwide. It can further exacerbate Zinc deficiency by reducing intake as well as absorption. British Obesity and Metabolic Surgery Society, therefore, recommends that Zinc level should be monitored routinely following gastric bypass. However, the American guidance does not recommend such monitoring for all RYGB patients and reserves it for T Z after RYGB. Routine monitoring of Zinc levels is hence unnecessary for asymptomatic patients after RYGB and should be reserved for patients with skin lesions, hair loss, pica, dysgeusia, hypogonadism or erectile dysfunction in male patients, and unexplained iron deficiency anaemia.

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Altered plasma response to zinc and iron tolerance test after Roux-en-Y gastric bypass

Cited by 19 publications

References 35 publications

Iron deficiency after bariatric surgery: what is the real problem?

Iron deficiency after bariatric surgery: what is the real problem?

Impact of Aging on Urinary Excretion of Iron and Zinc

Zinc Deficiency after Gastric Bypass for Morbid Obesity: a Systematic Review

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