Altered permeability of the erythrocyte membrane for sodium and potassium ions in spontaneously hypertensive rats

Postnov, Yu. V.; Orlov, Sergei N.; Gulak, Pavel V.; Shevchenko, A. S.

doi:10.1007/bf01067026

Cited by 119 publications

(25 citation statements)

References 5 publications

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“…In the mid-1970s, we showed that the passive (ouabain-insensitive) permeability of erythrocyte membrane for univalent cations is increased both in SHR 21 and in patients with essential hypertension. 22 Subsequent studies revealed that this abnormality is probably due to an increase of the rate of Na + -Na (Na + -Li + ) exchange 13 and Na + -K + cotransport.…”

Section: Discussionmentioning

confidence: 99%

Effect of protein kinase C activation on cytoskeleton and cation transport in human erythrocytes. Reproduction of some membrane abnormalities revealed in essential hypertension.

et al. 1988

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SUMMARY Certain manifestations of alterations of membrane cytoskeleton, protein kinase C activity, and ion transport were revealed in erythrocytes of patients with essential hypertension: 1) the average volume of erythrocytes is reduced by 4%; 2) about 7% of the total number of erythrocytes is represented by cup-shaped forms compared with 1.5 to 3.0% in the control group; 3) basal phospborylation of Band 4.9 protein is increased 1.6-fold to 1.8-fold; 4) activity of protein kinase C is increased by 60 to 70%; 5) the rate of proton electrochemical gradient (A/i H +)-induced Na + -H + exchange is increased twofold. Treatment of erythrocytes of healthy donors with protein kinase C activator (12-O-tetradecanoylphorbol-13-acetate) leads to similar but more marked changes in cell shape (17% of cup-shaped forms), volume reduction (by 7%), an increase of Band 4.9 protein phosphorylation (threefold), and an increase in the rate of Na + -H + exchange (fourfold). Protein kinase activation does not modify Na + -Li + exchange and slightly increases (by 20-50%) Na + -K + pump activity, Na + -K + cotransport, and the rate of ^a influx. It may be assumed that the increase of protein kinase C activity is one of the most probable molecular mechanisms conditioning abnormalities of the membrane skeleton and Na + -H + exchange in primary hypertension.

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Section: Discussionmentioning

confidence: 99%

Effect of protein kinase C activation on cytoskeleton and cation transport in human erythrocytes. Reproduction of some membrane abnormalities revealed in essential hypertension.

et al. 1988

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“…Our findings of altered membrane transport of calcium and sodium by the enterocyte of the SH rat agree with the behavior of several other types of cells. The erythrocyte of the SH rat shows increased sodium and potassium permeability (31) and decreased binding of calcium to the inner membrane surface (32). The adipocyte of the SH rat shows decreased calcium binding to the membrane (33), an increased intracellular calcium pool (34), and decreased membrane fluidity (35).…”

Section: Resultsmentioning

confidence: 99%

Calcium and sodium transport and vitamin D metabolism in the spontaneously hypertensive rat.

Schedl¹,

Miller²,

Pape³

et al. 1984

J. Clin. Invest.

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As bstract. Serum ionized calcium levels are lower and immunoreactive parathyroid hormone levels are higher in the spontaneously hypertensive (SH) rat than in the normotensive Wistar-Kyoto (WKy) control.We postulated that there is either a defect in the regulation ofvitamin D metabolism by parathyroid hormone or that the gut target organ for vitamin D in the SH rat is unresponsive. To test these hypotheses we measured serum concentrations of vitamin D metabolites and intestinal transport of calcium and sodium. Compared with that of WKy controls, in vitro calcium transport by duodenal sacs of the SH rat was decreased (P < 0.001) at 5 wk, before the development of hypertension, and at 12 wk, after hypertension was well established. When measured in vivo in the most proximal 20 cm of small intestine, maximum velocity (Vmax) for calcium transport was decreased (P < 0.05) and net absorption of sodium and water was increased (P < 0.05) in SH rats as compared with WKy rats. Vmax for calcium transport was also decreased (P < 0.05) in the most distal 20 cm of small intestine of SH rats, but net sodium and water transport were the same in SH and WKy rats. At 12 wk, serum concentration of 1 ,25-dihydroxycholecalciferol [1,2D3] was the same in both SH and Wry groups, but its precursor, 25-hydroxycholecalciferol, was increased (P < 0.05) in the SH rat. We conclude that in the SH rat: (a) the concentration of 1,25-(OH)2D3 is inappro-

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“…It should be mentioned that an enhancement of Na leak is a part of major ion transport abnormalities in SHR (6,7,10,25), in LHR and HTG rats (15), and in Sabra (25) and Dahl rats (26). The important role of the Na leak in the pathogenesis of spontaneous forms of experimental hypertension was confirmed by our earlier demonstration of a positive association between the Na leak and blood pressure in both SHR Brown Norway recombinant inbred strains (18) and HTG Lewis F2 hybrids (15).…”

Section: Discussionmentioning

confidence: 99%

Membrane Ion Transport in Erythrocytes of Salt Hypertensive Dahl Rats and Their F2 Hybrids: the Importance of Cholesterol

Vokurková¹,

Dobešová²,

Kuneš³

et al. 2003

Hypertens Res

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The possible association of salt hypertension and altered lipid metabolism with abnormalities of particular systems transporting sodium and potassium has been studied in erythrocytes of Dahl rats and their F2 hybrids fed a high-salt diet since weaning. Our attention was paid to the Na -K pump, Na -K cotransport and especially to passive membrane permeability for Na and Rb (Na and Rb leak), because the Na leak was found to be dependent on the genotype, age and salt intake of Dahl rats, whereas the Rb leak was sug-

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Altered permeability of the erythrocyte membrane for sodium and potassium ions in spontaneously hypertensive rats

Cited by 119 publications

References 5 publications

Effect of protein kinase C activation on cytoskeleton and cation transport in human erythrocytes. Reproduction of some membrane abnormalities revealed in essential hypertension.

Effect of protein kinase C activation on cytoskeleton and cation transport in human erythrocytes. Reproduction of some membrane abnormalities revealed in essential hypertension.

Calcium and sodium transport and vitamin D metabolism in the spontaneously hypertensive rat.

Membrane Ion Transport in Erythrocytes of Salt Hypertensive Dahl Rats and Their F2 Hybrids: the Importance of Cholesterol

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