“…Simpson et al [1985] found no changes in interpeak intervals in the click-evoked ABR response of old rats, as compared to young rats. In contrast, Cooper et al [1990] reported increased interpeak (WI-WV) intervals in aged rats in response to tone bursts.…”
Section: Auditory Brainstem Responsementioning
confidence: 75%
“…Simpson et al [1985] found that if clicks were presented to young and aged rats at equal levels relative to threshold (i.e. equal sensation levels), aging did not induce any absolute latency shift.…”
This study was designed to test whether old rats show signs of presbyacusis and whether they would be either similarly or more or less susceptible to noise-induced hearing loss than young adult rats. Old (24 months) and young adult (3–4 months) Wistar rats were exposed to a broad-band noise of 113 dB SPL for a duration of 1 h (producing temporary threshold shifts) or 3 days (12 h noise/12 h quiet; permanent shifts). Auditory brainstem response (ABR), distortion product otoacoustic emissions (DPOAEs) and transient evoked otoacoustic emissions (TEOAEs) were measured before and after exposure. At the initial recording (before exposure), old rats demonstrated a small mean ABR threshold elevation, a reduction in amplitude of wave I (WI), a shortening of WI latency and a prolongation of the interpeak interval between WI and WIV, as compared to the young rats. The old rats also demonstrated a small DPOAE amplitude reduction and a reduction of peak-to-peak amplitude in the TEOAE response 2 ms after stimulus, but no reduction in TEOAE energy content between 2 and 4 kHz. These are signs of presbyacusis in the old rats. The noise exposures caused elevations in ABR threshold and reductions in DPOAE amplitude and TEOAE energy content that were similar in both the old and young rats. Their recovery from the noise-induced loss was also similar. Thus, the results of this study show that old and young adult rats, at least when considering clinically relevant intensities and durations of noise exposure, are equally susceptible to the effects of the exposure.
“…Simpson et al [1985] found no changes in interpeak intervals in the click-evoked ABR response of old rats, as compared to young rats. In contrast, Cooper et al [1990] reported increased interpeak (WI-WV) intervals in aged rats in response to tone bursts.…”
Section: Auditory Brainstem Responsementioning
confidence: 75%
“…Simpson et al [1985] found that if clicks were presented to young and aged rats at equal levels relative to threshold (i.e. equal sensation levels), aging did not induce any absolute latency shift.…”
This study was designed to test whether old rats show signs of presbyacusis and whether they would be either similarly or more or less susceptible to noise-induced hearing loss than young adult rats. Old (24 months) and young adult (3–4 months) Wistar rats were exposed to a broad-band noise of 113 dB SPL for a duration of 1 h (producing temporary threshold shifts) or 3 days (12 h noise/12 h quiet; permanent shifts). Auditory brainstem response (ABR), distortion product otoacoustic emissions (DPOAEs) and transient evoked otoacoustic emissions (TEOAEs) were measured before and after exposure. At the initial recording (before exposure), old rats demonstrated a small mean ABR threshold elevation, a reduction in amplitude of wave I (WI), a shortening of WI latency and a prolongation of the interpeak interval between WI and WIV, as compared to the young rats. The old rats also demonstrated a small DPOAE amplitude reduction and a reduction of peak-to-peak amplitude in the TEOAE response 2 ms after stimulus, but no reduction in TEOAE energy content between 2 and 4 kHz. These are signs of presbyacusis in the old rats. The noise exposures caused elevations in ABR threshold and reductions in DPOAE amplitude and TEOAE energy content that were similar in both the old and young rats. Their recovery from the noise-induced loss was also similar. Thus, the results of this study show that old and young adult rats, at least when considering clinically relevant intensities and durations of noise exposure, are equally susceptible to the effects of the exposure.
“…Alcohol-addicted old rats, however, did not show any significant threshold changes when compared with either normal old rats or 3-month-old rats, or any latency shifts in waves I-V. We conclude that the toxic ef fects of alcohol are excerted at higher levels than the brainstem. Both in man and in rat, age-dependent latency shifts occur normally but without differences in wave I-IV con duction time [19,20].…”
Normative data for frequency-specific ( ± 100 Hz) auditory brainstem response (ABR) thresholds were determined in 60 normal healthy 3-month-old, 5 normal 22-month-old and 6 alcohol-addicted 22-month-old Sprague Dawley rats. The highest degree of auditory sensitivity was in the range of 12–20 kHz. These frequencies showed significant mean differences between the 3-month-old and the old normal rats. In contrast, alcohol-addicted old rats did not reveal any significant threshold changes as compared with either normal old or 3-month-old rats.
“…Broad-band clicks, as mostly used as stimulus in ABRbased aging studies [6][7][8], could be the source of the discrepancies in reported results, since they are not frequency-specific, but are used to analyse frequency-dependent changes. However, a few investigations utilizing either the 14 ORL 2000;62: [13][14][15][16][17][18][19] Stenqvist behavioural method or, more recently, burst-elicited ABR, have described the frequency distribution of agerelated hearing loss [5,9].…”
Section: Introductionmentioning
confidence: 99%
“…However, a few investigations utilizing either the 14 ORL 2000;62: [13][14][15][16][17][18][19] Stenqvist behavioural method or, more recently, burst-elicited ABR, have described the frequency distribution of agerelated hearing loss [5,9]. Age-related hearing loss is mostly associated with peripheral pathology, both in humans and in rats [8,10] and has been classified by Schuknecht [11] and Schuknecht and Gacek [12] as sensory, neural, strial and conductive cochlear.…”
Frequency-specific auditory brainstem responses to tone bursts (2–31.5 kHz) and tuning curves were recorded in 8 male rats during their entire life. No significant threshold elevation occurred during the 1st year. Mean age at onset of hearing loss was 20 months, with individual variations ranging from 14 up to 23 months. In most animals, threshold elevations were limited to 20 and 31.5 kHz. At age of 18–23 months, 3 rats were treated with Pseudomonas aeruginosa exotoxin A. After instillation, threshold elevation occurred at all frequencies, followed by near-total recovery at low frequencies, but only partial reversibility at high frequencies. It is concluded that aging-related hearing changes in Sprague-Dawley albino rats start at different ages, particularly comprising high frequencies and encroaching on the middle and low areas with increasing age.
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