Altered Patterns of Amplitude of Low-Frequency Fluctuations and Fractional Amplitude of Low-Frequency Fluctuations Between Amnestic and Vascular Mild Cognitive Impairment: An ALE-Based Comparative Meta-Analysis

Zhang, Xulian; Xue, Chen; Cao, Xuan; Yuan, Qianqian; Qi, Wenzhang; Xu, Wenwen; Zhang, Shaojun; Huang, Qingling

doi:10.3389/fnagi.2021.711023

Cited by 12 publications

(7 citation statements)

References 59 publications

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“…This study found that the sALFF in the above two brain regions of SLE patients with CI was higher than that of HCs and SLE patients without CI, respectively, suggesting that the local brain activity intensity of these two brain regions increased, which may be related to the compensation of cognitive dysfunction. Similar results have also been reported in studies of major depressive disorder (Liu et al, 2014), and amnestic CI (Zhang et al, 2021) and its specific mechanism still needs further research.…”

Section: Discussionsupporting

confidence: 86%

Dynamic changes of amplitude of low-frequency in systemic lupus erythematosus patients with cognitive impairment

Yang

Zhao²,

Zhang³

et al. 2022

Front. Neurosci.

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BackgroundCognitive dysfunction (CI) is frequently reported in patients with systemic lupus erythematosus (SLE), but the identification and assessment of SLE-related CI remain challenging. Previous studies have focused on changes in static brain activity, and no studies have investigated the characteristics of dynamic brain activity in SLE patients with CI.ObjectsWe calculated the dynamic amplitude of low-frequency fluctuation (dALFF) by combining the ALFF with a sliding window method to assess the temporal variability of brain functional activity in SLE patients with and without CI.MethodsThirty-eight SLE with CI, thirty-eight SLE without CI, and thirty-eight healthy controls (HCs) were recruited. By comparing static ALFF (sALFF) and dALFF among the three groups, changes in brain activity intensity and its temporal variability were assessed in patients with SLE with or without CI. Spearman correlation coefficients were calculated between the brain function indicator and Mini-mental State Examination (MMSE) scores of SLE with CI.ResultsSubjects among the three groups exhibited significant sALFF differences in the right parahippocampal gyrus, left caudate nucleus, right putamen, and left cuneus. Compared to the SLE without CI, the right parahippocampal gyrus exhibited higher sALFF in the SLE with CI group. Compared to the HCs, the left caudate nucleus exhibited increased sALFF in the SLE with CI group. Participants in the three groups exhibited significant dALFF variability in the right parahippocampal gyrus, right lingual gyrus, and bilateral inferior occipital gyrus. Compared to the HCs, the right lingual gyrus exhibited reduced dALFF in the SLE without CI group. Compared to the HCs, the right parahippocampal gyrus exhibited increased dALFF, left calcarine fissure, and the surrounding cortex exhibited reduced dALFF in the SLE with CI group. There was no significant correlation between the MMSE score, sALFF, and dALFF in the SLE with CI group.ConclusionSLE patients with CI have abnormal brain activity intensity and stability. By analyzing the dynamics of intrinsic brain activity, it provides a new idea for evaluating SLE-related CI. However, more research and validation with multiple metrics are needed to determine the link between the severity of cognitive impairment (CI) and brain activity in patients with SLE.

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Section: Discussionsupporting

confidence: 86%

Dynamic changes of amplitude of low-frequency in systemic lupus erythematosus patients with cognitive impairment

Yang

Zhao²,

Zhang³

et al. 2022

Front. Neurosci.

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“…The ALFF method has been applied to evaluate the neural mechanisms of central disease including schizophrenia ( 21 ), epilepsy ( 22 ), mild cognitive impairment ( 23 ), and migraine ( 24 ). Besides, many studies have suggested that the ALFF of fMRI signals are closely related to the spontaneous neuronal activities such as visual cortex ( 25 ), auditory cortex ( 26 ), hippocampus ( 27 ), cingulate cortex, and postcentral gyrus ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

The Association Between Precuneus Function and Residual Dizziness in Patients With Benign Paroxysmal Positional Vertigo

Bai

et al. 2022

Front. Neurol.

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ObjectivesThe purpose of this study was to apply the amplitude of the low-frequency fluctuation (ALFF) method to investigate the spontaneous brain activity alterations in patients with residual dizziness (RD) after successful canalith repositioning manoeuvre for benign paroxysmal positional vertigo (BPPV).MethodsAll BPPV patients underwent visual vertigo analog scale (VVAS) evaluations and functional magnetic resonance imaging (fMRI). The ALFF method was used to assess the spontaneous brain activity. Screening of brain regions with significant changes in ALFF values was based on analysis of the whole brain. We further analyze the relationship between ALFF values of the altered regions and VVAS scores in BPPV patients with RD.ResultsFifteen BPPV patients with RD and fifteen without RD were recruited in this study. In contrast to without RD, RD patients exhibited increased scores in VVAS tests (p < 0.001) and RD patients also showed significant ALFF decrease in the bilateral precuneus (left: 251 voxels; x = −10, y = −69, z = 51; peak t-value = −3.25; right: 170 voxels; x = 4, y = −59, z = 42; peak t-value = −3.43). Correlation analysis revealed that the mean ALFF z-values in the left precuneus displayed significant negative correlations with the VVAS scores(r = −0.44, p = 0.01).ConclusionsThis study shows that RD is associated with left precuneus function as revealed by fMRI. It might provide useful information for explaining neural mechanisms in BPPV patients with RD.

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“…While smoker/non-smoker differences have been reported in fALFF ( Wang et al, 2017 ; Tan et al, 2021 ; Weng et al, 2021 ), the interaction between fALFF, smoking status, and cognition is unknown. However, a growing literature has investigated the link between fALFF and cognitive impairment, and studies indicate increased fALFF values in the PHG among individuals with amnesic mild cognitive impairment ( Zhang et al, 2021 ). This suggests a compensatory mechanism in the early stage of cognitive impairment, and may be analogous to the reduced GMV and higher fALFF values in the smokers’ PHG that correlated with cognitive performance.…”

Section: Discussionmentioning

confidence: 99%

Cognition, Aryl Hydrocarbon Receptor Repressor Methylation, and Abstinence Duration-Associated Multimodal Brain Networks in Smoking and Long-Term Smoking Cessation

Fu²,

Wu³

et al. 2022

Front. Neurosci.

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Cigarette smoking and smoking cessation are associated with changes in cognition and DNA methylation; however, the neurobiological correlates of these effects have not been fully elucidated, especially in long-term cessation. Cognitive performance, percent methylation of the aryl hydrocarbon receptor repressor (AHRR) gene, and abstinence duration were used as references to supervise a multimodal fusion analysis of functional, structural, and diffusion magnetic resonance imaging (MRI) data, in order to identify associated brain networks in smokers and ex-smokers. Correlations among these networks and with smoking-related measures were performed. Cognition-, methylation-, and abstinence duration-associated networks discriminated between smokers and ex-smokers and correlated with differences in fractional amplitude of low frequency fluctuations (fALFF) values, gray matter volume (GMV), and fractional anisotropy (FA) values. Long-term smoking cessation was associated with more accurate cognitive performance, as well as lower fALFF and more GMV in the hippocampus complex. The methylation- and abstinence duration-associated networks positively correlated with smoking-related measures of abstinence duration and percent methylation, respectively, suggesting they are complementary measures. This analysis revealed structural and functional co-alterations linked to smoking abstinence and cognitive performance in brain regions including the insula, frontal gyri, and lingual gyri. Furthermore, AHRR methylation, a promising epigenetic biomarker of smoking recency, may provide an important complement to self-reported abstinence duration.

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Altered Patterns of Amplitude of Low-Frequency Fluctuations and Fractional Amplitude of Low-Frequency Fluctuations Between Amnestic and Vascular Mild Cognitive Impairment: An ALE-Based Comparative Meta-Analysis

Cited by 12 publications

References 59 publications

Dynamic changes of amplitude of low-frequency in systemic lupus erythematosus patients with cognitive impairment

Dynamic changes of amplitude of low-frequency in systemic lupus erythematosus patients with cognitive impairment

The Association Between Precuneus Function and Residual Dizziness in Patients With Benign Paroxysmal Positional Vertigo

Cognition, Aryl Hydrocarbon Receptor Repressor Methylation, and Abstinence Duration-Associated Multimodal Brain Networks in Smoking and Long-Term Smoking Cessation

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