Altered omega‐3 polyunsaturated fatty acid status in depressed post‐myocardial infarction patients

Abstract

Depressed post-MI patients had lower levels of n-3 LCPUFAs as measured by mean AA/EPA ratio and no signs of increased inflammation as determined by CRP levels.

Is there a role forn-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials

“…(1998) (63) C major depression (64) C major depression (65) C major depression (66) C and SC major depression (67) C major depression in ACS patients (68) C major depression in ACS patients (69) C depression in MI patients (70) C postpartum (71) C major depression (72) C major depression (74) NC adolescent depression (75) NC depression in lung cancer patients…”

Post-Myocardial Infarction Depression

“…Moreover, PUFA omega-3 induces the expression of the Bcl-2 anti-apoptotic protein and reduces the activation of caspase-3 (Bazan 2009;Sinha et al 2009). In the more specific case of post-MI depression, it can be mentioned that omega-3 fatty acid levels were found to be lower in plasma and red blood cell membrane of depressed patients with acute coronary syndromes than non-depressed patients (Schins et al 2007;Amin et al 2008). Our own results show that an PUFA omega-3-rich diet reduces post-MI apoptosis in the limbic system ) and depressive behavior (unpublished observations).…”

Treatment of post-myocardial infarction depressive disorder

“…LCPUFAs might increase the serotonin-mediated neurotransmission, decrease the immune activation and decrease the activation of the HPA axis. It appears that compared with nondepressed patients, depressed post-MI patients have significantly higher arachidonic acid/eicosapentanoic acid (AA/EPA) ratios, proving that depressed post-MI patients have lower levels of n-3 LCPUFAs [21]. Lowered serum-esterified cholesterol and PUFA phospholipid fractions are related to membrane viscosity and fluidity [19].…”