Altered nocturnal growth hormone (GH) secretion in obsessive compulsive disorder

Kluge, Michael; Schüssler, P.; Weikel, J.; Dresler, Martin; Zuber, Verena; Querfurt, Florian; Yassouridis, Alexander; Steiger, Axel

doi:10.1016/j.psyneuen.2006.07.002

Cited by 16 publications

(10 citation statements)

References 37 publications

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“…Consistent with the differences in ghrelin levels between patients with OCD and major depression and healthy subjects, other endocrine parameters have been found to be similarly changed in patients compared to healthy subjects. For example, in both disorders, the activity of the HPA axis is increased and the activity of the somatotropic axis is decreased, as indicated by a suppressed sleep-related GH surge [4,47,48] .…”

Section: Discussionmentioning

confidence: 99%

Ghrelin Plasma Levels Are Not Altered in Major Depression

Kluge¹,

Schüssler²,

Schmid³

et al. 2009

Neuropsychobiology

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Background: In patients with major depression, the function of most endocrine axes is altered compared to healthy subjects. The orexigenic hormone ghrelin, which shows higher plasma levels in females than males, interacts with several of these endocrine axes. In addition, ghrelin levels in depressed patients decrease with psychopathological improvement. Therefore, we hypothesized that ghrelin levels in patients with major depression would be higher than in healthy subjects. Methods: Nocturnal (20:00–07:00 h) secretion patterns of ghrelin in 20 patients with major depression [11 females, age 39.4 ± 10.2 years (mean ± standard deviation); 9 males, age 38.3 ± 10.4 years] with a total score on the Hamilton Depression Rating Scale, 21-item version, of 24.8 ± 5.2 and 20 healthy subjects [11 females, age 38.7 ± 10.8 years; 9 males, age 39.1 ± 11.2 years] were determined following an adaptation night. Results: Ghrelin plasma levels of depressed patients and matched healthy subjects did not differ at any point in time when stratified for sex. Accordingly, the area under the curve was comparable: depressed females, 423.3 ± 103.4; healthy females, 398.0 ± 94.6; depressed males, 266.3 ± 56.9, and healthy males, 228.4 ± 41.3. Conclusion: This is the first comparison of ghrelin secretion patterns in patients with major depression and healthy controls. Surprisingly, no relevant differences were ascertained between the two groups.

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Section: Discussionmentioning

confidence: 99%

Ghrelin Plasma Levels Are Not Altered in Major Depression

Kluge¹,

Schüssler²,

Schmid³

et al. 2009

Neuropsychobiology

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“…The results showed that responses of GH (that stimulates IGF-1 hepatic production) to growth hormone-releasing hormone stimulation were blunted in OCD patients, thus suggesting impairment in the mechanisms regulating GH secretion in OCD [23]. In a subsequent study the nocturnal GH secretion in patients with OCD was found to be altered compared to controls [24]. Hence, available data seem to suggest a complex dysfunction of the somatotropic axis in OCD; the etiopathogenetic significance of this alteration is still obscure.…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Insulin-Like Growth Factor-1 and Obsessive-Compulsive Disorder: A Case-Control Study

et al. 2016

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Background/Aims: Recent findings suggest an involvement of insulin-like growth factor-1 (IGF-1) in the pathogenesis of many psychiatric disorders; however, there is a lack of data regarding IGF-1 in patients with obsessive-compulsive disorder (OCD). The aims of the present study were (1) to analyze putative alterations of IGF-1 serum content in patients with OCD compared to patients with major depressive disorder (MDD) and healthy controls, and (2) to analyze putative changes of IGF-1 levels during drug treatment in subjects with OCD compared to patients with MDD. Methods: We recruited 40 OCD patients, 37 MDD patients, and 43 healthy controls. All participants were adults. Serum IGF-1 levels were measured by the ELISA method on venous blood samples collected at baseline and after 10 ± 1 weeks of drug treatment. Results: IGF-1 levels were increased in OCD patients compared to controls (149.9 ± 60.2 vs. 121.2 ± 51.6 ng/ml; p = 0.040). No correlations were observed between baseline IGF-1 levels, clinical features, and response to treatment at follow-up in OCD or MDD patients. No changes in serum IGF-1 were observed after drug treatment. Conclusion: Our results show for the first time that serum IGF-1 levels are altered in patients with OCD. Further research on the role of IGF-1 in OCD is warranted.

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“…In a study examining OCDrelated impairment across multiple domains, Piacentini, Bergman, Keller, and McCracken (2003) reported that 66% and 56% of parents noted that OCD interfered with their child ''getting ready for bed night'' and ''sleeping at night.'' Among adults with OCD, evidence suggests a number of sleep related problems including altered nocturnal growth hormone secretion (Kluge et al, 2006;Kluge, Schussler, Dresler, Yassouridis, & Steiger, 2007a), disturbed sleep continuity (Volderhozer et al, 2006), and rapid eye movement sleep abnormalities (Insel, Roy, Cohen, & Murphy, 1982;Kluge, Schussler, Kunzel, et al, 2007b;see Hohagen et al, 1994 andRobinson, Wasleben, Pollack, &Lerner, 1998 for exceptions). Bobdey, Fineberg, Gale, Patel, and Davies (2002) found that adult patients with OCD exhibited worse sleep quality, latency, and daytime dysfunction relative to healthy controls.…”

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confidence: 99%

Sleep-related problems in pediatric obsessive-compulsive disorder

Storch

Murphy

Lack

et al. 2008

Journal of Anxiety Disorders

112

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Although attention has been given to presence of sleep related problems (SRPs) in children with psychiatric conditions, little has been reported on SRPs in youth with obsessive-compulsive disorder (OCD). Sixty-six children and adolescents with OCD were administered the Children's Yale Brown Obsessive-Compulsive Scale and completed the Children's Depression Inventory and Multidimensional Anxiety Scale. Their parents completed the Child Behavior Checklist and Children's Obsessive-Compulsive Impact Scale. A subset of youth (n=41) completed a trial of cognitive-behavioral therapy. Frequency of eight specific SRPs was examined in relation to age, gender, OCD symptom severity, child-rated symptoms of depression and anxiety, parent-proxy ratings of internalizing and externalizing problems, and functional impairment. Ninety-two percent of youth experienced at least one SRP, with 27.3% reporting five or more SRPs. Total SRPs were positively associated with OCD symptom severity, child-rated anxiety, and parent-proxy ratings of internalizing problems. Total and several specific SRPs were reduced following cognitive-behavioral treatment. These results suggest that SRPs are relatively common in youth with OCD, are associated with symptom severity, and warrant attention during assessment and treatment.

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Altered nocturnal growth hormone (GH) secretion in obsessive compulsive disorder

Cited by 16 publications

References 37 publications

Ghrelin Plasma Levels Are Not Altered in Major Depression

Ghrelin Plasma Levels Are Not Altered in Major Depression

Serum Levels of Insulin-Like Growth Factor-1 and Obsessive-Compulsive Disorder: A Case-Control Study

Sleep-related problems in pediatric obsessive-compulsive disorder

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