Altered Nocturnal Cardiovascular Control in Children With Sleep-Disordered Breathing

El-Hamad, Fatima; Immanuel, Sarah A.; Liu, Xiao; Pamula, Yvonne; Kontos, Anna; Martin, James; Kennedy, Declan; Kohler, Mark; Porta, Alberto; Baumert, Mathias

doi:10.1093/sleep/zsx127

Cited by 8 publications

(2 citation statements)

References 40 publications

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“…To date, multiple studies sought to demonstrate the molecular consequences of untreated OSA. Previous results suggest that progression of disease is directly or indirectly mediated by disruption of neural control (ie, changes to the sympathetic nervous system), [22][23][24] increased oxidative stress, [25][26][27][28] or endothelial dysfunction. 10,[29][30][31] Upregulation of a systemic inflammatory response was strongly implicated in OSA disease progression, [32][33][34][35][36] and evaluation of inflammatory biomarkers provided insight into the potential role of the circadian clock in the disease process.…”

Section: Molecular Pathways Disrupted In Osamentioning

confidence: 99%

Circadian Dysregulation: The Next Frontier in Obstructive Sleep Apnea Research

Allmen

Francey

Rogers

et al. 2018

Otolaryngol.--head neck surg.

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Pediatric OSA is highly prevalent and, if left untreated, may lead to cardiopulmonary sequelae. Changes in inflammatory markers that normally demonstrate circadian rhythmicity are also seen among patients with OSA. Hypoxia-inducible transcription factors interact with core circadian clock transcription factors; however, the interplay between these pathways has not been elucidated in the cardiopulmonary system. This gap in knowledge hinders our ability to identify potential biomarkers of OSA and develop alternative therapeutic strategies. A deeper understanding of the mechanisms by which OSA impinges on clock function and the impact of clock dysregulation on the cardiopulmonary system may lead to future advancements for the care of patients with OSA. The aim of this review is to shed light on this important clinical topic.

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Section: Molecular Pathways Disrupted In Osamentioning

confidence: 99%

Circadian Dysregulation: The Next Frontier in Obstructive Sleep Apnea Research

Allmen

Francey

Rogers

et al. 2018

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

show abstract

“…Most children are at the milder end of this spectrum. UAO has often been associated with impairment of neurocognitive and behavioral function, but increasing evidence suggests that it also affects autonomic cardiovascular control [2][3][4][5]. Importantly, OSAS is a key driver of change in the cardiovascular system [6][7][8] and may increase the risk of developing cardiovascular disease later in life [4,5,9].…”

Section: Introductionmentioning

confidence: 99%