“…MRS/NMR methods have been used to characterize chemical compounds since the 1950s, but clinical application of MRS is relatively novel [ 23 ]. Since the approval of MRS for clinical use in 1995, MRS has been used to study brain tumors, cancer, stroke, seizure disorders, Parkinson’s, Alzheimer’s, anxiety, schizophrenia, bipolar disorders, and autism spectrum disorders [ 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. There is also a huge potential for MRS to be utilized in clinical addiction research.…”