Altered neuronal activity in the pedunculopontine nucleus: An electrophysiological study in a rat model of Parkinson’s disease

Geng, Xiwen; Xie, Jinlu; Wang, Xuenan; Wang, Xiusong; Zhang, Xiao; Hou, Yabing; Lei, Chengdong; Li, Min; Qu, Qingyang; He, Ting; Han, Hongyu; Yao, Xiaomeng; Wang, Min

doi:10.1016/j.bbr.2016.02.026

Cited by 30 publications

(33 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in contrast to those results, no other peak in higher frequency bands (including gamma) was visible in the power spectra in the rats included in our study. This is consistent with the observation that the firing of single PPN neurons during actual locomotion was less than 6 Hz in normal rats (Geng et al, 2016). These same authors reported LFP results from PPN during locomotion consistent with our findings from effective MLR sites, with the highest percentage of relative LFP power observed in the 0.7–12 Hz range.…”

Section: Discussionsupporting

confidence: 92%

LFP Oscillations in the Mesencephalic Locomotor Region during Voluntary Locomotion

Noga

Sánchez

Villamil

et al. 2017

Front. Neural Circuits

View full text Add to dashboard Cite

Oscillatory rhythms in local field potentials (LFPs) are thought to coherently bind cooperating neuronal ensembles to produce behaviors, including locomotion. LFPs recorded from sites that trigger locomotion have been used as a basis for identification of appropriate targets for deep brain stimulation (DBS) to enhance locomotor recovery in patients with gait disorders. Theta band activity (6–12 Hz) is associated with locomotor activity in locomotion-inducing sites in the hypothalamus and in the hippocampus, but the LFPs that occur in the functionally defined mesencephalic locomotor region (MLR) during locomotion have not been determined. Here we record the oscillatory activity during treadmill locomotion in MLR sites effective for inducing locomotion with electrical stimulation in rats. The results show the presence of oscillatory theta rhythms in the LFPs recorded from the most effective MLR stimulus sites (at threshold ≤60 μA). Theta activity increased at the onset of locomotion, and its power was correlated with the speed of locomotion. In animals with higher thresholds (>60 μA), the correlation between locomotor speed and theta LFP oscillations was less robust. Changes in the gamma band (previously recorded in vitro in the pedunculopontine nucleus (PPN), thought to be a part of the MLR) were relatively small. Controlled locomotion was best achieved at 10–20 Hz frequencies of MLR stimulation. Our results indicate that theta and not delta or gamma band oscillation is a suitable biomarker for identifying the functional MLR sites.

show abstract

Section: Discussionsupporting

confidence: 92%

LFP Oscillations in the Mesencephalic Locomotor Region during Voluntary Locomotion

Noga

Sánchez

Villamil

et al. 2017

Front. Neural Circuits

View full text Add to dashboard Cite

show abstract

“…These findings suggest that the branching GPi projections to brainstem nuclei, such as the PPN, may be more important for the development of bradykinesia or akinesia than traditionally assumed. PPN dysfunction is usually blamed for dopamine‐insensitive gait and balance problems in PD (e.g., see previous works), but experiments in primates and rodents have suggested that lesions of the PPN (area) can elicit at least transient hypokinesia, and that stimulation of this site in parkinsonian animals appears to have beneficial effects . In distinction from the parkinsonism‐associated oscillations in the basal ganglia/thalamocortical circuits, parkinsonism is accompanied by increased alpha‐band oscillations in the PPN in PD patients, modulated by movement and gait performance, and emphasized in the ON‐state .…”

Section: Evolving Topicsmentioning

confidence: 99%

“…PPN dysfunction is usually blamed for dopamine-insensitive gait and balance problems in PD (e.g., see previous works 159,255 ), but experiments in primates and rodents have suggested that lesions of the PPN (area) can elicit at least transient hypokinesia, and that stimulation of this site in parkinsonian animals appears to have beneficial effects. [256][257][258][259][260][261][262][263][264][265][266][267][268] In distinction from the parkinsonism-associated oscillations in the basal ganglia/ thalamocortical circuits, parkinsonism is accompanied by increased alpha-band oscillations in the PPN in PD patients, modulated by movement and gait performance, [269][270][271] and emphasized in the ONstate. [272][273][274] Interestingly, beta-band synchronization, which is proparkinsonian in the basal ganglia and cortex, appears to be associated with reversal of parkinsonism in the PPN.…”

Section: Role Of Brainstem Nucleimentioning

confidence: 99%

Changing views of the pathophysiology of Parkinsonism

Wichmann

2019

Movement Disorders

View full text Add to dashboard Cite

Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia) have a long history and primarily model the consequences of dopamine loss in the basal ganglia on the function of the basal ganglia/thalamocortical circuit(s). Changes of firing rates of individual nodes within these circuits were originally considered central to parkinsonism. However, this view has now given way to the belief that changes in firing patterns within the basal ganglia and related nuclei are more important, including the emergence of burst discharges, greater synchrony of firing between neighboring neurons, oscillatory activity patterns, and the excessive coupling of oscillatory activities at different frequencies. Primarily focusing on studies obtained in nonhuman primates and human patients with Parkinson's disease, this review summarizes the current state of this field and highlights several emerging areas of research, including studies of the impact of the heterogeneity of external pallidal neurons on parkinsonism, the importance of extrastriatal dopamine loss, parkinsonism‐associated synaptic and morphologic plasticity, and the potential role(s) of the cerebellum and brainstem in the motor dysfunction of Parkinson's disease. © 2019 International Parkinson and Movement Disorder Society

show abstract

“…PPN provides a potent glutamatergic innervation of vulnerable ventral tier SNc DA neurons . Activity in the PPN, like that of the STN, rises in PD models and in PD patients, suggesting that it could provide an additional excitotoxic drive.…”

Section: Does Network Dysfunction Accelerate Progression?mentioning

confidence: 99%

Determinants of dopaminergic neuron loss in Parkinson's disease

2018

View full text Add to dashboard Cite

The cardinal motor symptoms of Parkinson's disease (PD) are caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SNc). Alpha‐synuclein (aSYN) pathology and mitochondrial dysfunction have been implicated in PD pathogenesis, but until recently it was unclear why SNc dopaminergic neurons should be particularly vulnerable to these two types of insult. In this brief review, the evidence that SNc dopaminergic neurons have an anatomical, physiological, and biochemical phenotype that predisposes them to mitochondrial dysfunction and synuclein pathology is summarized. The recognition that certain traits may predispose neurons to PD‐linked pathology creates translational opportunities for slowing or stopping disease progression.

show abstract

Altered neuronal activity in the pedunculopontine nucleus: An electrophysiological study in a rat model of Parkinson’s disease

Cited by 30 publications

References 41 publications

LFP Oscillations in the Mesencephalic Locomotor Region during Voluntary Locomotion

LFP Oscillations in the Mesencephalic Locomotor Region during Voluntary Locomotion

Changing views of the pathophysiology of Parkinsonism

Determinants of dopaminergic neuron loss in Parkinson's disease

Contact Info

Product

Resources

About