Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy

Dávila‐Román, Víctor G.; Vedala, Giridhar; Herrero, Pilar; Fuentes, Lisa de las; Rogers, Joseph G.; Kelly, Daniel P.; Gropler, Robert J.

doi:10.1016/s0735-1097(02)01967-8

Cited by 442 publications

(321 citation statements)

References 32 publications

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“…Of note, in patients with heart failure, including DCM and ischemic heart disease, FAO is reduced but glucose metabolism is favored, recapitulating the fetal metabolic program. These changes are associated with diminution of Ppargc1a and Esrra expression (31,32). The signals leading to their down-regulation during heart failure are still elusive (33), although MYC has been proposed as a potential upstream repressor of Ppargc1a transcription (34).…”

Section: Dissection Of Moribund Med30mentioning

confidence: 99%

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

Krebs¹,

Fan

Chen

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Deficiencies of subunits of the transcriptional regulatory complex Mediator generally result in embryonic lethality, precluding study of its physiological function. Here we describe a missense mutation in Med30 causing progressive cardiomyopathy in homozygous mice that, although viable during lactation, show precipitous lethality 2-3 wk after weaning. Expression profiling reveals pleiotropic changes in transcription of cardiac genes required for oxidative phosphorylation and mitochondrial integrity. Weaning mice to a ketogenic diet extends viability to 8.5 wk. Thus, we establish a mechanistic connection between Mediator and induction of a metabolic program for oxidative phosphorylation and fatty acid oxidation, in which lethal cardiomyopathy is mitigated by dietary intervention.heart | metabolism | peroxisome proliferator-activated receptor-γ coactivator-1α

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Section: Dissection Of Moribund Med30mentioning

confidence: 99%

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

Krebs¹,

Fan

Chen

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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“…According to some studies, PCOS patients have an increased risk for diabetes mellitus [1,2] and often show an adverse cardiovascular risk profile -increased rate of arterial hypertension [3,4], dislipidemia [4][5][6][7] and subclinical inflammation and atherosclerosis [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

MCP-1 and fetuin A levels in patients with PCOS and/or obesity before and after metformin treatment

2013

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“…68,69 METABOLIC IMAGING In patients with a hypertrophic or dilated LV cardiomyopathy, PET imaging has shown that the predominant metabolic substrate of the LV has switched from fatty acids to glucose metabolism, thereby preserving the adenosine triphosphate supply for force generation. [70][71][72] In line with these findings, single-photon emission tomography (SPECT) imaging has demonstrated that, in the hypertrophied RV of patients with PH, myocardial fatty acid uptake was decreased. 73 Although it has been shown that measuring myocardial glucose metabolism using PET with 18 F-2-deoxy-2-fluoro-D-glucose ( 18 FDG) tracers is feasible in patients with PAH, 74 inconsistent results have been reported.…”

Section: Regional Rv Function and Strainmentioning

confidence: 93%

State of the Art: Advanced Imaging of the Right Ventricle and Pulmonary Circulation in Humans (2013 Grover Conference Series)

et al. 2014

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Pulmonary arterial hypertension (PAH) is a progressive disease characterized by remodeling and vasoconstriction of the pulmonary vasculature, ultimately leading to right ventricular (RV) failure and death. Recent developments in echocardiography, cardiovascular magnetic resonance imaging, computed tomography, and positron emission tomography allow advanced, noninvasive, in vivo assessment of the RV and have contributed to the identification of risk factors, prognostic factors, and monitoring of therapeutic responses in patients with PAH. Although far from reaching its future potential, these techniques have not only provided global RV assessment but also allowed evaluation of changes in cellular and molecular tissue processes, such as metabolism, oxygen balance and ischemia, angiogenesis, and apoptosis. Integrated application of these techniques could provide full insights into the different pathophysiological aspects of a failing RV in the setting of PAH. Recent advances in hybrid imaging have implemented simultaneous measurements of myocardial and vascular interactions and will be one of the most important potential future developments.

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Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy

Cited by 442 publications

References 32 publications

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

MCP-1 and fetuin A levels in patients with PCOS and/or obesity before and after metformin treatment

State of the Art: Advanced Imaging of the Right Ventricle and Pulmonary Circulation in Humans (2013 Grover Conference Series)

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