Altered Mycobiota Signatures and Enriched Pathogenic Aspergillus rambellii Are Associated With Colorectal Cancer Based on Multicohort Fecal Metagenomic Analyses

Lin, Yufeng; Lau, Harry Cheuk-Hay; Liu, Yali; Kang, Xing; Wang, Yiwei; Ting, Nick Lung-Ngai; Kwong, Thomas; Han, Jing; Liu, Weixin; Liu, Changan; She, Junjun; Wong, Sunny H.; Sung, Joseph J.Y.; Yu, Jun

doi:10.1053/j.gastro.2022.06.038

Cited by 59 publications

(65 citation statements)

References 37 publications

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“…Fungi and viruses also impact the gut microbiota and host ( van Tilburg Bernardes et al, 2020 ), although knowledge about their relationship with dysbiosis is limited ( Carding et al, 2017 ; Beller and Matthijnssens, 2019 ). A recent study identified signature fungi in colorectal cancer and adenoma patients from multiple cohorts, and observed trans-kingdom interactions between enteric fungi and bacteria in colorectal cancer progression ( Lin et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

The gut microbiome in human health and disease—Where are we and where are we going? A bibliometric analysis

Huang

Liu

et al. 2022

Front. Microbiol.

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BackgroundThere are trillions of microbiota in our intestinal tract, and they play a significant role in health and disease via interacting with the host in metabolic, immune, neural, and endocrine pathways. Over the past decades, numerous studies have been published in the field of gut microbiome and disease. Although there are narrative reviews of gut microbiome and certain diseases, the whole field is lack of systematic and quantitative analysis. Therefore, we outline research status of the gut microbiome and disease, and present insights into developments and characteristics of this field to provide a holistic grasp and future research directions.MethodsAn advanced search was carried out in the Web of Science Core Collection (WoSCC), basing on the term “gut microbiome” and its synonyms. The current status and developing trends of this scientific domain were evaluated by bibliometric methodology. CiteSpace was used to perform collaboration network analysis, co-citation analysis and citation burst detection.ResultsA total of 29,870 articles and 13,311 reviews were retrieved from the database, which involve 42,900 keywords, 176 countries/regions, 19,065 institutions, 147,225 authors and 4,251 journals. The gut microbiome and disease research is active and has received increasing attention. Co-cited reference analysis revealed the landmark articles in the field. The United States had the largest number of publications and close cooperation with other countries. The current research mainly focuses on gastrointestinal diseases, such as inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn’s disease (CD), while extra-intestinal diseases are also rising, such as obesity, diabetes, cardiovascular disease, Alzheimer’s disease, Parkinson’s disease. Omics technologies, fecal microbiota transplantation (FMT) and metabolites linked to mechanism would be more concerned in the future.ConclusionThe gut microbiome and disease has been a booming field of research, and the trend is expected to continue. Overall, this research field shows a multitude of challenges and great opportunities.

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Section: Discussionmentioning

confidence: 99%

The gut microbiome in human health and disease—Where are we and where are we going? A bibliometric analysis

Huang

Liu

et al. 2022

Front. Microbiol.

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“…Ascomycota is the most prevalent phylum, covering 48% to 99% of all present species. In contrast, Basidiomycota is the less abundant phylum, ranging between 0.5% to 14% of identified microscopic fungi, followed by the phylum Mucoromycota [ 14 , 15 ]. Two mycotypes can be distinguished in the gut.…”

Section: Introductionmentioning

confidence: 99%

The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders

et al. 2022

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The gastrointestinal (GI) tract is one of the most studied compartments of the human body as it hosts the largest microbial community including trillions of germs. The relationship between the human and its associated flora is complex, as the microbiome plays an important role in nutrition, metabolism and immune function. With a dynamic composition, influenced by many intrinsic and extrinsic factors, there is an equilibrium maintained in the composition of GI microbiota, translated as “eubiosis”. Any disruption of the microbiota leads to the development of different local and systemic diseases. This article reviews the human GI microbiome’s composition and function in healthy individuals as well as its involvement in the pathogenesis of different digestive disorders. It also highlights the possibility to consider flora manipulation a therapeutic option when treating GI diseases.

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“…[1][2][3] However, the role of gut fungal microbiota in etiology and progression of CRC is undiscovered due to the low abundance of fungi in the human gut (0.1%-1% of total microorganisms) as well as a lack of well-characterized reference genomes for aligning sequencing reads. 4 The fungal community has gained much more attention recently because of the additive value of fungi to the predictive model of the gut microbiome in colon carcinogenesis, which may provide an ideal approach for screening and early detection of CRC. 4 Characterizing the human mycobiota (group of all fungi) or mycobiome (the entirety of fungi and their genome) in healthy individuals has showed that the gastrointestinal tract contains hundreds of fungal species.…”

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confidence: 99%

“…4 The fungal community has gained much more attention recently because of the additive value of fungi to the predictive model of the gut microbiome in colon carcinogenesis, which may provide an ideal approach for screening and early detection of CRC. 4 Characterizing the human mycobiota (group of all fungi) or mycobiome (the entirety of fungi and their genome) in healthy individuals has showed that the gastrointestinal tract contains hundreds of fungal species. As the smaller proportion of the commensal microbial community, fungi were considered passive colonizers that could become pathogenic when the environment changes (eg, use of antibiotics or immunosuppressive drugs that reduce or suppress the microbe community).…”

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confidence: 99%

“…Yu and colleagues 4 initiated a meta-analysis to pool studies with shotgun metagenomic sequencing data, totaling 1329 metagenomes (454 CRC, 350 adenoma, and 525 healthy subjects) from 8 cohorts and intended to a provide less biased evaluation of the gut mycobiome on CRC. 4 The results of mycobiota composition analysis revealed a number of enriched (eg, Aspergillus rambellii, Cordyceps sp. RAO Q3 -2017, Erysiphe pulchra, Moniliophthora perniciosa, Sphaerulina musiva, and Phytophthora capsica) and depleted fungal species (eg, A kawachii) that are associated with CRC.…”

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confidence: 99%

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Mycobiota Signatures and Colorectal Cancer: A True Association or Not?

2022

Gastroenterology

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Altered Mycobiota Signatures and Enriched Pathogenic Aspergillus rambellii Are Associated With Colorectal Cancer Based on Multicohort Fecal Metagenomic Analyses

Cited by 59 publications

References 37 publications

The gut microbiome in human health and disease—Where are we and where are we going? A bibliometric analysis

The gut microbiome in human health and disease—Where are we and where are we going? A bibliometric analysis

The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders

Mycobiota Signatures and Colorectal Cancer: A True Association or Not?

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