Altered Motor-Striatal Plasticity and Cortical Functioning in Patients with Schizophrenia

Zhou, Dongsheng; Pan, Feng; Liu, Shiyan; Shen, Ying; Liu, Lingjiang; Fang, Zezhong; Wang, Chuang; Hu, Zhenyu; Yuan, Ti‐Fei

doi:10.1007/s12264-016-0079-9

Cited by 16 publications

(14 citation statements)

References 22 publications

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“…The relationship between total GMV and treatment effect in the posterior rMFC model also indicates their correlation in a way. The progression of schizophrenia is accompanied by altered cortical plasticity and functioning [ 56 ], and longitudinal GMV reduction has been found in many studies, especially in frontal cortical regions [ 12 , 36 – 38 ]. As for other variables, our analysis revealed that the treatment effect on total and negative symptoms was worsened by family history.…”

Section: Discussionmentioning

confidence: 99%

Progressive Grey Matter Volume Changes in Patients with Schizophrenia over 6 Weeks of Antipsychotic Treatment and Their Relationship to Clinical Improvement

Zhang

Liao

et al. 2018

Neurosci. Bull.

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Cross-sectional and longitudinal studies have identified widespread and progressive grey matter volume (GMV) reductions in schizophrenia, especially in the frontal lobe. In this study, we found a progressive GMV decrease in the rostral medial frontal cortex (rMFC, including the anterior cingulate cortex) in the patient group during a 6-week follow-up of 40 patients with schizophrenia and 31 healthy controls well-matched for age, gender, and education. The higher baseline GMV in the rMFC predicted better improvement in the positive score on the Positive and Negative Syndrome Scale (PANSS), and this might be related to the improved reality-monitoring. Besides, a higher baseline GMV in the posterior rMFC predicted better remission of general symptoms, and a lesser GMV reduction in this region was correlated with better remission of negative symptoms, probably associated with ameliorated self-referential processing and social cognition. Besides, a shorter disease course and higher educational level contributed to better improvement in the general psychopathological PANSS score, and a family history was negatively associated with improvement of the negative and total PANSS scores. These phenomena might be important for understanding the neuropathological mechanisms underlying the symptoms of schizophrenia and for making clinical decisions.

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Section: Discussionmentioning

confidence: 99%

Progressive Grey Matter Volume Changes in Patients with Schizophrenia over 6 Weeks of Antipsychotic Treatment and Their Relationship to Clinical Improvement

Zhang

Liao

et al. 2018

Neurosci. Bull.

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“…Future studies on a larger scale will be performed. It will be also interesting to quantify the motor cortical changes following training with non-invasive measurement approaches, for instance ( Huang et al, in press ; Shen et al, 2017 ; Zhou et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Exercise training with dietary restriction enhances circulating irisin level associated with increasing endothelial progenitor cell number in obese adults: an intervention study

Huang

Wang

et al. 2017

PeerJ

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ObjectiveCirculating endothelial progenitor cells (EPCs) correlate negatively with obesity. Previous studies have shown that exercise significantly restores circulating EPC levels in obese people; however, the underlying mechanisms have not been elucidated. Recently, irisin has been reported to have a critical role in the regulation of EPCs. This exercise-induced myokine has been demonstrated to play a therapeutic role in obesity. In this study, we hypothesized that the increase in circulating irisin may form a link with increasing EPC levels in obese people after exercise.MethodsSeventeen obese adults completed an 8-week program of combined exercise and dietary intervention. Clinical characteristics, blood biochemistry, and circulating irisin levels of subjects were measured before and after eight weeks of training. EPC levels were evaluated via flow cytometry, and EPC migratory and adhesive functions were also determined.ResultsCirculating irisin levels significantly increased following the 8-week training program (P < 0.05). We furthermore observed an improvement in EPC numbers (P < 0.05), and EPC migratory and adhesive functions (P < 0.001 and P < 0.05, respectively) after the intervention. Additionally, we detected a positive correlation between changes in irisin and changes in EPC number (r = 0.52, P < 0.05).DiscussionFor the first time, a positive correlation between increasing irisin levels and increasing EPC levels has been reported after an 8-week program, consisting of exercise and dietary intervention. This result suggests a novel effect of irisin on the regulation of EPC mobilization, which might contribute to improvement of endothelial function in obese people.

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“…In rotary pursuit motor learning task, the human subjects were asked to trace a point on the rotating plate with a probe (instrument from Bei Da Qing Niao, Beijing, China), and the time for the probe to successfully contact the rotating point was measured in 4 trials separated by 10 min each. 21 Before the test, the subjects were familiarized with the test but were allowed less than three trials to prevent overlearning. The speed of the rotating plate was adjusted to reach a starting baseline between 10 and 25 s.…”

Section: Methodsmentioning

confidence: 99%

Methamphetamine abuse impairs motor cortical plasticity and function

Huang

Shen

et al. 2017

Mol Psychiatry

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Exposure to addictive drugs triggers synaptic plasticity in reward-related brain regions, such as the midbrain, nucleus accumbens and the prefrontal cortex. Effects of chronic drug exposure on other brain areas have not been fully investigated. Here, we characterize synaptic plasticity in motor cortex after methamphetamine self-administration in rats. We show that this causes a loss of corticostriatal plasticity in rat brain slices and impaired motor learning in the rotarod task. These findings are paralleled by the observation of a lack of transcranial magnetic stimulation-induced potentiation or depression of motor evoked potentials in human patients with addiction, along with poor performance in rotary pursuit task. Taken together, our results suggest that chronic methamphetamine use can affect behavioral performance via drug-evoked synaptic plasticity occluding physiological motor learning.

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Altered Motor-Striatal Plasticity and Cortical Functioning in Patients with Schizophrenia

Cited by 16 publications

References 22 publications

Progressive Grey Matter Volume Changes in Patients with Schizophrenia over 6 Weeks of Antipsychotic Treatment and Their Relationship to Clinical Improvement

Progressive Grey Matter Volume Changes in Patients with Schizophrenia over 6 Weeks of Antipsychotic Treatment and Their Relationship to Clinical Improvement

Exercise training with dietary restriction enhances circulating irisin level associated with increasing endothelial progenitor cell number in obese adults: an intervention study

Methamphetamine abuse impairs motor cortical plasticity and function

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