Altered motor network recruitment during finger tapping in boys with tourette syndrome

Roessner, Veit; Wittfoth, Matthias; Schmidt‐Samoa, Carsten; Rothenberger, Aribert; Dechent, Peter; Baudewig, Jürgen

doi:10.1002/hbm.21240

Cited by 27 publications

(31 citation statements)

References 54 publications

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“…Additionally, and in accordance with the latter study, which, surprisingly, found a shorter than normal BP, Moretto showed that patients with GTS have a delayed experience of volition (Moretto, Schwingenschuh, Katschnig, Bhatia, & Haggard, 2011). This would imply that not only the formation of tics but also the formation of normal movements would necessitate an altered pattern of motor organization through fronto-striato-thalamocortical pathways, as supported by current findings (Heise et al, 2010;Roessner et al, 2011). Furthermore, in the absence of direct evidence to support the notion that the awareness of urges correlates positively with the ability to suppress tics--a suppression, which, according to Jackson et al, would lead to the propagation of the urge and further activation of the anterior insula--the role of frontomesial networks of volitional inhibition (Kühn, Haggard, & Brass, 2009) and tic suppression has to be addressed in detail.…”

Section: Characteristicsupporting

confidence: 88%

On the functional anatomy of the urge-for-action

Jackson

Parkinson

Kim

et al. 2011

Cognitive Neuroscience

119

127

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Several common neuropsychiatric disorders (e.g., obsessive-compulsive disorder, Tourette syndrome (TS), autistic spectrum disorder) are associated with unpleasant bodily sensations that are perceived as an urge for action. Similarly, many of our everyday behaviors are also characterized by bodily sensations that we experience as urges for action. Where do these urges originate? In this paper, we consider the nature and the functional anatomy of "urges-for-action," both in the context of everyday behaviors such as yawning, swallowing, and micturition, and in relation to clinical disorders in which the urge-for-action is considered pathological and substantially interferes with activities of daily living (e.g., TS). We review previous frameworks for thinking about behavioral urges and demonstrate that there is considerable overlap between the functional anatomy of urges associated with everyday behaviors such as swallowing, yawning, and micturition, and those urges associated with the generation of tics in TS. Specifically, we show that the limbic sensory and motor regions--insula and mid-cingulate cortex--are common to all of these behaviors, and we argue that this "motivation-for-action" network should be considered distinct from an "intentional action" network, associated with regions of premotor and parietal cortex, which may be responsible for the perception of "willed intention" during the execution of goal-directed actions.Keywords: Urge; Urge-for-action; Habit; Insula; Tourette syndrome; Action.Many of our everyday behaviors are characterized by bodily sensations that we experience either as an urge or a desire for action. For instance, we may experience a sensation that our bladder is full that is accompanied, to a greater or lesser extent, by an urge or desire to urinate (micturate). In extreme cases, this sense of fullness can be quite uncomfortable and the urge to urinate can be hard to suppress. Similarly, we may experience a tickle in our throat that is associated with an urge to cough or to swallow that can also be difficult to suppress voluntarily.However, not all urges for action are necessarily preceded by bodily sensations of which we are aware. For example, we may suddenly experience a strong urge to yawn, or even find ourselves yawning, without being aware of a sensory "trigger" for the action. In this paper, we consider the nature and the functional anatomy of these "urges-for-action," both in the context of everyday behaviors such as yawning, swallowing, and urinating, and in relation to clinical disorders in which the urgefor-action is considered pathological and substantially COGNITIVE NEUROSCIENCE, 2011, 2 (3-4), Commentaries, and Reply) Correspondence should be addressed to: Stephen R. Jackson, School of Psychology, University of Nottingham, Nottingham NG7 2RD, UK. E-mail: stephen.jackson@nottingham.ac.uk This research was supported in part by grants from the Medical Research Council (G0901321), and by the WCU (World Class University) program through the National Research Foundatio...

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Section: Characteristicsupporting

confidence: 88%

On the functional anatomy of the urge-for-action

Jackson

Parkinson

Kim

et al. 2011

Cognitive Neuroscience

119

127

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“…[30][31][32][33] Tobe et al 33 found decreased regional volumes of the cerebellar hemispheres during a finger-tapping test in patients with TS. The authors hypothesize that the cerebellum might be involved in the pathogenesis of TS.…”

Section: Functional Correlates Of Voluntary Motor Executionmentioning

confidence: 99%

“…In a preceding study, based on movements of the right index finger, the same authors found reduced premotor and prefrontal activations and increased activations of the right medial frontal gyrus and the left caudate in patients with TS compared with healthy controls. 31 The hemispheric preponderance of this task might be the reason for this discrepancy. 32 In contrast, one study did not find any differences in activation patterns during a finger-tapping task between children with TS and healthy controls.…”

Section: Functional Correlates Of Voluntary Motor Executionmentioning

confidence: 99%

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Functional neuroimaging in Tourette syndrome: recent perspectives

Debes¹,

Préel²,

Skov³

2017

NAN

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“…Many patients are able to suppress their tics on demand [9]. The underlying mechanism is not well understood, but most studies agree that a widespread frontal network is involved in voluntary tic suppression [10].…”

Section: Introductionmentioning

confidence: 99%

Using voluntary motor commands to inhibit involuntary arm movements

2014

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A hallmark of voluntary motor control is the ability to stop an ongoing movement. Is voluntary motor inhibition a general neural mechanism that can be focused on any movement, including involuntary movements, or is it mere termination of a positive voluntary motor command? The involuntary arm lift, or 'floating arm trick', is a distinctive long-lasting reflex of the deltoid muscle. We investigated how a voluntary motor network inhibits this form of involuntary motor control. Transcranial magnetic stimulation of the motor cortex during the floating arm trick produced a silent period in the reflexively contracting deltoid muscle, followed by a rebound of muscle activity. This pattern suggests a persistent generator of involuntary motor commands. Instructions to bring the arm down voluntarily reduced activity of deltoid muscle. When this voluntary effort was withdrawn, the involuntary arm lift resumed. Further, voluntary motor inhibition produced a strange illusion of physical resistance to bringing the arm down, as if ongoing involuntarily generated commands were located in a 'sensory blind-spot', inaccessible to conscious perception. Our results suggest that voluntary motor inhibition may be a specific neural function, distinct from absence of positive voluntary motor commands.

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Altered motor network recruitment during finger tapping in boys with tourette syndrome

Cited by 27 publications

References 54 publications

On the functional anatomy of the urge-for-action

On the functional anatomy of the urge-for-action

Functional neuroimaging in Tourette syndrome: recent perspectives

Using voluntary motor commands to inhibit involuntary arm movements

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