Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident

Goldenberg, David; Russo, Mariano; Houser, Kenneth R.; Crist, Henry; Derr, Jonathan; Walter, Vonn; Warrick, Joshua I.; Sheldon, Kathryn; Broach, James R.; Bann, Darrin V.

doi:10.1002/lary.26687

Cited by 13 publications

(10 citation statements)

References 39 publications

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“…In the present study, we analyzed FFPE tissue sections obtained from 50 patients with TC using an Illumina Miseq sequencer. Since 2013, only 2 reports concerning PC and 2 reports concerning PDC and AC were published describing results of mutational analyses using NGS with FFPE tissue sections (2,(35)(36)(37). Tumor samples are histologically heterogeneous (15), and tumor-specific DNA contains varying proportions of contaminating DNA from normal and inflammatory cells.…”

Section: Discussionmentioning

confidence: 99%

Targeted next‑generation sequencing of cancer‑related genes in thyroid carcinoma: A single institution's experience

et al. 2018

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Thyroid carcinoma (TC) has characteristic genetic alterations, including point mutations in proto-oncogenes and chromosomal rearrangements that vary by histologic subtype. Recent developments in next-generation sequencing (NGS) technology enable simultaneous analysis of cancer-associated genes of interest, thus improving diagnostic accuracy and allowing precise personalized treatment for human cancer.

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Section: Discussionmentioning

confidence: 99%

Targeted next‑generation sequencing of cancer‑related genes in thyroid carcinoma: A single institution's experience

et al. 2018

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“…According to earlier data, multifocality is a hallmark of radiation-related TCs, which are characterized by genetic diversity and inconsistent gene variant patterns [29,30]. Similar to radiotoxic injury, thyroid follicular cells are exposed to continuous and direct cellular irritation as a consequence of autoimmune inflammation.…”

Section: Discussionmentioning

confidence: 99%

High Genetic Diversity and No Evidence of Clonal Relation in Synchronous Thyroid Carcinomas Associated with Hashimoto’s Thyroiditis: A Next-Generation Sequencing Analysis

et al. 2020

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The close association between pre-existing Hashimoto’s thyroiditis and thyroid cancer is well established. The simultaneous occurrence of multiple neoplastic foci within the same organ suggests a common genotoxic effect potentially contributing to carcinogenesis, the nature of which is still not clear. Next-generation sequencing (NGS) provides a potent tool to demonstrate and compare the mutational profile of the independent neoplastic foci. Our collection of 47 cases with thyroid carcinoma and Hashimoto’s thyroiditis included 14 with at least two tumorous foci. Detailed histological analysis highlighted differences in histomorphology, immunoprofile, and biological characteristics. Further, a 67-gene NGS panel was applied to demonstrate the mutational diversity of the synchronic tumors. Significant differences could be detected with a wide spectrum of pathogenic gene variants involved (ranging between 5 and 18, cutoff >5.0 variant allele frequencies (VAF)). Identical gene variants represented in both synchronous tumors of the same thyroid gland were found in only two cases (BRAF and JAK3 genes). An additional set of major driver mutations was identified at variable allele frequencies in a highly individual setup suggesting a clear clonal independence. The different BRAF statuses in coincident thyroid carcinoma foci within the same organ outline a special challenge for molecular follow-up and therapeutic decision-making.

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“…The report assessed presence or absence of genetic mutations in DNA and RNA of 44 thyroid cancer patients who lived near the Three Cases had a significantly (p = 0.04) lower proportion of BRAFV600 Emutations, which are not associated with radiation-induced thyroid cancer. Authors conclude that the data suggest radiation released from the meltdown may have contributed to the development of thyroid cancer in some patients [35].…”

Section: Journal Of Environmental Protectionmentioning

confidence: 97%

Rising Thyroid Cancer Incidence Proximate to a New York City-Area Nuclear Power Plant

Mangano¹,

Sherman²

2017

JEP

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Thyroid cancer incidence has risen steadily in the US for several decades. While any cause of this trend has yet to be clearly identified, most analyses have concluded that there are factors other than improved detection accounting for the increase. Since exposure to radioactive iodine is the only acknowledged root cause of thyroid cancer, a review of temporal trends in incidence since the late 1970s near the Indian Point nuclear power plant,

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Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident

Abstract: 4 Laryngoscope, 127:S1-S9, 2017.

Cited by 13 publications

References 39 publications

Targeted next‑generation sequencing of cancer‑related genes in thyroid carcinoma: A single institution's experience

Targeted next‑generation sequencing of cancer‑related genes in thyroid carcinoma: A single institution's experience

High Genetic Diversity and No Evidence of Clonal Relation in Synchronous Thyroid Carcinomas Associated with Hashimoto’s Thyroiditis: A Next-Generation Sequencing Analysis

Rising Thyroid Cancer Incidence Proximate to a New York City-Area Nuclear Power Plant

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