Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy

Integrative mRNA-microRNA analyses reveal novel interactions related to insulin sensitivity in human adipose tissue

“…Intriguingly, of 17 microRNAs that were differentially expressed between IR and IS, 16 were lower in IR individuals. These findings are in keeping with recent evidence indicating that adipocyte-specific reductions in microRNA levels result in decreased adipose mass and severe insulin resistance in mice (30). This loss of adipose tissue following reduced microRNA levels may be due to impaired adipogenesis, as there is a global upregulation in microRNA levels during adipocyte differentiation (12).…”

Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals

“…In contrast, the expression of general adipocyte marker genes, including Ppar ␥ 2 , ap2 , and C/ebp ␣ , was not altered ( Fig. 3C ), while leptin, a WAT marker gene ( 39 ), was downregulated ( Fig. 3C ).…”

miRNA regulation of white and brown adipose tissue differentiation and function

“…Indeed, adipocyte specific disruption of miRNA processing, by knockout of DGCR8 or DICER, has been demonstrated to both alter WAT accumulation and promote the whitening of BAT, leading to impaired metabolic function [8, 9]. Additionally, numerous studies have identified individual miRNAs that play critical roles in the regulation of adipogenesis in WAT and BAT.…”